Aplastic anemia classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.D. [2] Nazia Fuad M.D.

Overview

Aplastic anemia may be classified according to blood cell counts into 3 subgroups, moderately severe aplastic anemia or non severe AA (nSAA), severe aplastic anemia (SAA), and very severe aplastic anemia(vSAA).

Classification

Aplastic anemia may be classified according to blood cell counts into 3 subgroups:[1]

  • Moderately severe aplastic anemia or non severe AA (nSAA)
  • Severe aplastic anemia (SAA)
  • Very severe aplastic anemia(vSAA)
Classification of aplastic anemia (two out of three criteria must be met)
nSAA SAA vSAA
Reticulocytes <20G/L <20G/L <20G/L
Platelets <50 G / L <20G/L <20G/L
Neutrophilic granulocytes <1.0 G / L <0.5G/L 0.2G/L

This classification is of prognostic relevance and has an influence on therapeutic procedures.

Classification based on the presumed etiology

classification based on the presumed etiology
Acquired aplastic anemia
Idiopathic
Secondary Irradiation

Drugs and chemicals: cytotoxic agents, benzene, chloromphenicol, gold

salts, NSAIDS

Idiosyncratic reactions

Viruses: Epstein Barr virus, parvovirus B19, HIV

Immune diseases

Pregnancy

PNH Paroxysmal nocturnal hemoglobinuria

Inherited aplastic anemia Fanconi anemia

Dyskeratosis congenital

Amegakaryocytic thrombocytopenia

Shwachman-Diamond syndrome

References

  1. Dolberg OJ, Levy Y (2014). "Idiopathic aplastic anemia: diagnosis and classification". Autoimmun Rev. 13 (4–5): 569–73. doi:10.1016/j.autrev.2014.01.014. PMID 24424170.