Aplastic anemia causes: Difference between revisions

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==Causes==
==Causes==
===Acquired Causes===
Many diseases, conditions, and factors can cause aplastic anemia, including:
* Toxins, such as [[pesticides]], [[arsenic]], and [[benzene]].
* Radiation and chemotherapy
* Medicines, such as [[Albendazole]], [[Cefadroxil]], [[Chlorpromazine]], [[chloramphenicol]] (an antibiotic rarely used in the United States, [[Carbamazepine]], [[Hydroxychloroquine]], [[Methimazole]], [[Orphenadrine]], [[Oxcarbazepine]], [[Phenytoin]], [[Quinine]], [[Phenylbutazone]], [[Sulindac]], [[Sulfadiazine]], [[Sulfasalazine]], [[Valganciclovir hydrochloride]].
* Infectious diseases, such as [[hepatitis]], [[Epstein-Barr virus]], [[cytomegalovirus]], [[parvovirus B19]], and [[HIV]].
* [[Collagen vascular disease]]
* [[Thymoma]]
* Autoimmune disorders, such as lupus and [[rheumatoid arthritis]].
* [[Pregnancy]] (aplastic anemia that occurs during pregnancy often goes away after delivery.)
* Metastaic involvement of bone marrow
===Inherited Causes===
Certain inherited conditions can damage the stem cells and lead to aplastic anemia. Examples include:
* [[Fanconi anemia]]
* [[Shwachman-Diamond syndrome]]
* [[Dyskeratosis congenita]]
* [[Diamond-Blackfan anemia]].
===Drugs Associated===
* [[Ceftazidime]] 
* [[Cefaclor]]
* [[Cefaclor]]
* [[Certolizumab pegol]]
* [[Chlorpropamide]]
* [[Chloramphenicol sodium succinate]]
* [[Dactinomycin]]
* [[Dapsone]]
* [[Eltrombopag]]
* [[Felbamate]]
* [[Flurbiprofen]]
* [[Flucytosine]]
* [[interferon alfacon-1]]
* [[Isoniazid]]
* [[Lincomycin Hydrochloride]]
* [[Meprobamate]]
* [[Nilutamide]]
* [[Oxaprozin]]
* [[Penicillamine]]
* [[Probenecid]]
* [[Tolbutamide]]
* [[Tolazamide]]
* [[Sodium aurothiomalate]]
* [[Sodium phenylbutyrate]]
* [[Sulfamethoxazole/Trimethoprim (oral)]]
* [[Sulfasalazine]]
* [[Sulfacetamide]]
===Other Causes===
* Exposure to [[toxin]]s
* [[Radiation]] or [[chemotherapy]]
* Have certain infectious diseases, [[autoimmune disorder]]s, or inherited conditions
=== Life-threatening Causes[edit | edit source] ===
=== Life-threatening Causes[edit | edit source] ===
* Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated. There are no life-threatening causes of disease name, however complications resulting from untreated disease name is common.
* There are no life-threatening causes of aplastic anemia.
* Life-threatening causes of [symptom/manifestation] include [cause1], [cause2], and [cause3].
* [Cause] is a life-threatening cause of [disease].


=== Common Causes ===
=== Common Causes ===
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* Idiopathic
* Idiopathic
* Infectious diseases, such as [[hepatitis]], [[Epstein-Barr virus]], [[cytomegalovirus]], [[parvovirus B19]], and [[HIV]].
* Infectious diseases, such as [[hepatitis]], [[Epstein-Barr virus]], [[cytomegalovirus]], [[parvovirus B19]], and [[HIV]].
* Medicines, such as [[Albendazole]], [[Cefadroxil]], [[Chlorpromazine]], [[chloramphenicol]] (an antibiotic rarely used in the United States, [[Carbamazepine]], [[Hydroxychloroquine]], [[Methimazole]], [[Orphenadrine]], [[Oxcarbazepine]], [[Phenytoin]], [[Quinine]], [[Phenylbutazone]], [[Sulindac]], [[Sulfadiazine]], [[Sulfasalazine]], [[Valganciclovir hydrochloride]].
* Medicines, such as [[Albendazole]], [[Cefadroxil]], [[Chlorpromazine]], [[chloramphenicol]] , [[Carbamazepine]], [[Hydroxychloroquine]], [[Methimazole]], [[Orphenadrine]], [[Oxcarbazepine]], [[Phenytoin]], [[Quinine]], [[Phenylbutazone]], [[Sulindac]], [[Sulfadiazine]], [[Sulfasalazine]], [[Valganciclovir hydrochloride]].
* [[Radiation]] or [[chemotherapy]]
* [[Radiation]]
* [[chemotherapy]]
* Toxins, such as [[pesticides]], [[arsenic]], and [[benzene]]
* Toxins, such as [[pesticides]], [[arsenic]], and [[benzene]]
=== Less Common Causes[edit | edit source] ===
* Metastasis
Less common causes of [disease name] include:<ref name="Young2002" />
=== Less Common Causes ===
* Autoimmune disorders, such as lupus and [[rheumatoid arthritis]].
Less common causes of aplastic anemia include:<ref name="Young2002" />
* [Cause2]
* [[Lupus erythematosis|Lupus (SLE)]]  
* [Cause3]
* R[[rheumatoid arthritis|heumatoid arthritis]].


=== Genetic Causes[edit | edit source] ===
* Pregnancy
* [Disease name] is caused by a mutation in the [gene name] gene.
* [[Thymoma]]
* [[Collagen vascular disease]]
 
=== Genetic Causes ===
 
Certain genetic conditions can damage the stem cells and lead to aplastic anemia:
* [[Fanconi anemia]]
* [[Shwachman-Diamond syndrome]]
* [[Dyskeratosis congenita]]
* [[Diamond-Blackfan anemia]].


===Causes by Organ System===
===Causes by Organ System===
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|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Drug Side Effect'''
| '''Drug Side Effect'''
| bgcolor="Beige" | No underlying causes
| bgcolor="Beige" | [[Albendazole]], [[Cefadroxil]], [[Chlorpromazine]], [[chloramphenicol]] , [[Carbamazepine]], [[Hydroxychloroquine]], [[Methimazole]], [[Orphenadrine]], [[Oxcarbazepine]], [[Phenytoin]], [[Quinine]], [[Phenylbutazone]], [[Sulindac]], [[Sulfadiazine]], [[Sulfasalazine]], [[Valganciclovir hydrochloride]]
|-
|-
|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
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|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Endocrine'''
| '''Endocrine'''
| bgcolor="Beige" | No underlying causes
| bgcolor="Beige" | [[Thymoma]]
|-
|-
|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
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|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Genetic'''
| '''Genetic'''
| bgcolor="Beige" | No underlying causes
| bgcolor="Beige" | [[Fanconi anemia]]
 
[[Shwachman-Diamond syndrome]]
 
[[Dyskeratosis congenita]] [[Diamond-Blackfan anemia]]
|-
|-
|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
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|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Infectious Disease'''
| '''Infectious Disease'''
| bgcolor="Beige" | No underlying causes
| bgcolor="Beige" | [[hepatitis]], [[Epstein-Barr virus]], [[cytomegalovirus]], [[parvovirus B19]], and [[HIV]].
|-
|-
|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
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|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Overdose/Toxicity'''
| '''Overdose/Toxicity'''
| bgcolor="Beige" | No underlying causes
| bgcolor="Beige" | [[pesticides]], [[arsenic]], and [[benzene]]
|-
|-
|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
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|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Rheumatology/Immunology/Allergy'''
| '''Rheumatology/Immunology/Allergy'''
| bgcolor="Beige" | No underlying causes
| bgcolor="Beige" | [[SLE]], R[[rheumatoid arthritis|heumatoid arthritis]]
|-
|-
|- bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
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|}
|}


=== Causes in Alphabetical Order[edit | edit source] ===
=== Causes in Alphabetical Order ===
List the causes of the disease in alphabetical order:
 
* Cause 1
* [[Autoimmune diseases]]
* Cause 2
* [[Albendazole]]
* Cause 3
* [[Arsenic]]
* Cause 4
* [[Benzene]]
* [[Ceftazidime]]
* [[Cefaclor]]
* [[Cefaclor]]
* [[Certolizumab pegol]]
* [[Chlorpropamide]]
* [[Chloramphenicol sodium succinate]]
* [[Dactinomycin]]
* [[Dapsone]]
* [[Dyskeratosis congenita]]
* [[Diamond-Blackfan anemia]].
* [[Eltrombopag]]
* [[Fanconi anemia]]
* [[Felbamate]]
* [[Flurbiprofen]]
* [[Flucytosine]]
* [[interferon alfacon-1]]
* [[Isoniazid]]
* [[Lincomycin Hydrochloride]]
* [[Meprobamate]]
* [[Nilutamide]]
* [[Oxaprozin]]
* [[Penicillamine]]
* [[Probenecid]]
* [[pesticides]]
* [[Tolbutamide]]
* [[Tolazamide]]
* [[Sodium aurothiomalate]]
* [[Sodium phenylbutyrate]]
* [[Sulfamethoxazole/Trimethoprim (oral)|Sulfamethoxazole/Trimethoprim]]
* [[Sulfasalazine]]
* [[Sulfacetamide]]
* [[Thymoma]]


==References==
==References==

Revision as of 14:29, 20 August 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.D. [2]

Overview

The cause of the damage can be acquired or inherited. Acquired aplastic anemia is more common, and sometimes it's only temporary. Inherited aplastic anemia is rare. More than half of the cases of aplastic anemia are idiopathic. Chemicals, drugs, viral infections, collagen vascular diseases, and thymoma can be implicated as the causative factor in the other cases. Some research suggests that stem cell damage may occur because the body's immune system attacks its own cells by mistake.

Causes

Life-threatening Causes[edit | edit source]

  • There are no life-threatening causes of aplastic anemia.

Common Causes

Common causes of aplastic anemia may include:[1]

Less Common Causes

Less common causes of aplastic anemia include:[1]

Genetic Causes

Certain genetic conditions can damage the stem cells and lead to aplastic anemia:

Causes by Organ System

Cardiovascular No underlying causes
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect Albendazole, Cefadroxil, Chlorpromazine, chloramphenicol , Carbamazepine, Hydroxychloroquine, Methimazole, Orphenadrine, Oxcarbazepine, Phenytoin, Quinine, Phenylbutazone, Sulindac, Sulfadiazine, Sulfasalazine, Valganciclovir hydrochloride
Ear Nose Throat No underlying causes
Endocrine Thymoma
Environmental No underlying causes
Gastroenterologic No underlying causes
Genetic Fanconi anemia

Shwachman-Diamond syndrome

Dyskeratosis congenita Diamond-Blackfan anemia

Hematologic No underlying causes
Iatrogenic No underlying causes
Infectious Disease hepatitis, Epstein-Barr virus, cytomegalovirus, parvovirus B19, and HIV.
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic No underlying causes
Ophthalmologic No underlying causes
Overdose/Toxicity pesticides, arsenic, and benzene
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal/Electrolyte No underlying causes
Rheumatology/Immunology/Allergy SLE, Rheumatoid arthritis
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous No underlying causes

Causes in Alphabetical Order

References

  1. 1.0 1.1 Young, Neal S. (2002). "Acquired Aplastic Anemia". Annals of Internal Medicine. 136 (7): 534. doi:10.7326/0003-4819-136-7-200204020-00011. ISSN 0003-4819.