https://www.wikidoc.org/index.php?title=Aortic_sclerosis_pathophysiology&feed=atom&action=history
Aortic sclerosis pathophysiology - Revision history
2024-03-28T22:02:38Z
Revision history for this page on the wiki
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WikiBot: Bot: Adding CME Category::Cardiology
2016-03-14T23:03:30Z
<p>Bot: Adding <a href="/index.php?title=CME_Category::Cardiology&action=edit&redlink=1" class="new" title="CME Category::Cardiology (page does not exist)">CME Category::Cardiology</a></p>
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WikiBot
https://www.wikidoc.org/index.php?title=Aortic_sclerosis_pathophysiology&diff=641262&oldid=prev
Lakshmi Gopalakrishnan at 17:14, 11 April 2012
2012-04-11T17:14:52Z
<p></p>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Disturbances in mineral metabolism such as '''''higher serum phosphate concentration''''' has shown to contribute to the development of [[aortic sclerosis]].<ref name="pmid21737022">{{cite journal |author=Linefsky JP, O'Brien KD, Katz R, de Boer IH, Barasch E, Jenny NS, Siscovick DS, Kestenbaum B |title=Association of serum phosphate levels with aortic valve sclerosis and annular calcification: the cardiovascular health study |journal=[[Journal of the American College of Cardiology]] |volume=58 |issue=3 |pages=291–7 |year=2011 |month=July |pmid=21737022 |doi=10.1016/j.jacc.2010.11.073 |url=http://linkinghub.elsevier.com/retrieve/pii/S0735-1097(11)01488-4 |accessdate=2012-04-11}}</ref><ref name="pmid19073826">{{cite journal |author=Adeney KL, Siscovick DS, Ix JH, Seliger SL, Shlipak MG, Jenny NS, Kestenbaum BR |title=Association of serum phosphate with vascular and valvular calcification in moderate CKD |journal=[[Journal of the American Society of Nephrology : JASN]] |volume=20 |issue=2 |pages=381–7 |year=2009 |month=February |pmid=19073826 |pmc=2637048 |doi=10.1681/ASN.2008040349 |url=http://jasn.asnjournals.org/cgi/pmidlookup?view=long&pmid=19073826 |accessdate=2012-04-11}}</ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Disturbances in mineral metabolism such as '''''higher serum phosphate concentration''''' has shown to contribute to the development of [[aortic sclerosis]].<ref name="pmid21737022">{{cite journal |author=Linefsky JP, O'Brien KD, Katz R, de Boer IH, Barasch E, Jenny NS, Siscovick DS, Kestenbaum B |title=Association of serum phosphate levels with aortic valve sclerosis and annular calcification: the cardiovascular health study |journal=[[Journal of the American College of Cardiology]] |volume=58 |issue=3 |pages=291–7 |year=2011 |month=July |pmid=21737022 |doi=10.1016/j.jacc.2010.11.073 |url=http://linkinghub.elsevier.com/retrieve/pii/S0735-1097(11)01488-4 |accessdate=2012-04-11}}</ref><ref name="pmid19073826">{{cite journal |author=Adeney KL, Siscovick DS, Ix JH, Seliger SL, Shlipak MG, Jenny NS, Kestenbaum BR |title=Association of serum phosphate with vascular and valvular calcification in moderate CKD |journal=[[Journal of the American Society of Nephrology : JASN]] |volume=20 |issue=2 |pages=381–7 |year=2009 |month=February |pmid=19073826 |pmc=2637048 |doi=10.1681/ASN.2008040349 |url=http://jasn.asnjournals.org/cgi/pmidlookup?view=long&pmid=19073826 |accessdate=2012-04-11}}</ref></div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">==Aortic Sclerosis & Atherosclerosis==</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">====[[Aortic sclerosis risk factors#Aortic Sclerosis as a Risk Factor for Coronary Artery Disease|Aortic Sclerosis as a Risk Factor for Coronary Artery Disease]]====</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">====[[Aortic sclerosis natural history#Progression to Aortic Stenosis|Progression to Aortic Stenosis]]====</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==References==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==References==</div></td></tr>
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Lakshmi Gopalakrishnan
https://www.wikidoc.org/index.php?title=Aortic_sclerosis_pathophysiology&diff=641261&oldid=prev
Lakshmi Gopalakrishnan: /* Pathophysiology */
2012-04-11T17:14:24Z
<p><span dir="auto"><span class="autocomment">Pathophysiology</span></span></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 17:14, 11 April 2012</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Aortic sclerosis is '''''non-obstructive degeneration''''' of the aortic valve developed consequently to [[calcification of the aortic valve]] and macrophage accumulation which is dependent on the synthesis of osteopontin protein.<ref name="pmid7554197">{{cite journal |author=O'Brien KD, Kuusisto J, Reichenbach DD, Ferguson M, Giachelli C, Alpers CE, Otto CM |title=Osteopontin is expressed in human aortic valvular lesions |journal=[[Circulation]] |volume=92 |issue=8 |pages=2163–8 |year=1995 |month=October |pmid=7554197 |doi= |url=http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=7554197 |accessdate=2012-04-11}}</ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Aortic sclerosis is '''''non-obstructive degeneration''''' of the aortic valve developed consequently to [[calcification of the aortic valve]] and macrophage accumulation which is dependent on the synthesis of osteopontin protein.<ref name="pmid7554197">{{cite journal |author=O'Brien KD, Kuusisto J, Reichenbach DD, Ferguson M, Giachelli C, Alpers CE, Otto CM |title=Osteopontin is expressed in human aortic valvular lesions |journal=[[Circulation]] |volume=92 |issue=8 |pages=2163–8 |year=1995 |month=October |pmid=7554197 |doi= |url=http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=7554197 |accessdate=2012-04-11}}</ref></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>*Disturbances in mineral metabolism such as higher serum phosphate concentration has shown to contribute to the development of [[aortic sclerosis]].<ref name="pmid21737022">{{cite journal |author=Linefsky JP, O'Brien KD, Katz R, de Boer IH, Barasch E, Jenny NS, Siscovick DS, Kestenbaum B |title=Association of serum phosphate levels with aortic valve sclerosis and annular calcification: the cardiovascular health study |journal=[[Journal of the American College of Cardiology]] |volume=58 |issue=3 |pages=291–7 |year=2011 |month=July |pmid=21737022 |doi=10.1016/j.jacc.2010.11.073 |url=http://linkinghub.elsevier.com/retrieve/pii/S0735-1097(11)01488-4 |accessdate=2012-04-11}}</ref><ref name="pmid19073826">{{cite journal |author=Adeney KL, Siscovick DS, Ix JH, Seliger SL, Shlipak MG, Jenny NS, Kestenbaum BR |title=Association of serum phosphate with vascular and valvular calcification in moderate CKD |journal=[[Journal of the American Society of Nephrology : JASN]] |volume=20 |issue=2 |pages=381–7 |year=2009 |month=February |pmid=19073826 |pmc=2637048 |doi=10.1681/ASN.2008040349 |url=http://jasn.asnjournals.org/cgi/pmidlookup?view=long&pmid=19073826 |accessdate=2012-04-11}}</ref></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>*Disturbances in mineral metabolism such as <ins style="font-weight: bold; text-decoration: none;">'''''</ins>higher serum phosphate concentration<ins style="font-weight: bold; text-decoration: none;">''''' </ins>has shown to contribute to the development of [[aortic sclerosis]].<ref name="pmid21737022">{{cite journal |author=Linefsky JP, O'Brien KD, Katz R, de Boer IH, Barasch E, Jenny NS, Siscovick DS, Kestenbaum B |title=Association of serum phosphate levels with aortic valve sclerosis and annular calcification: the cardiovascular health study |journal=[[Journal of the American College of Cardiology]] |volume=58 |issue=3 |pages=291–7 |year=2011 |month=July |pmid=21737022 |doi=10.1016/j.jacc.2010.11.073 |url=http://linkinghub.elsevier.com/retrieve/pii/S0735-1097(11)01488-4 |accessdate=2012-04-11}}</ref><ref name="pmid19073826">{{cite journal |author=Adeney KL, Siscovick DS, Ix JH, Seliger SL, Shlipak MG, Jenny NS, Kestenbaum BR |title=Association of serum phosphate with vascular and valvular calcification in moderate CKD |journal=[[Journal of the American Society of Nephrology : JASN]] |volume=20 |issue=2 |pages=381–7 |year=2009 |month=February |pmid=19073826 |pmc=2637048 |doi=10.1681/ASN.2008040349 |url=http://jasn.asnjournals.org/cgi/pmidlookup?view=long&pmid=19073826 |accessdate=2012-04-11}}</ref></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Aortic Sclerosis & Atherosclerosis==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Aortic Sclerosis & Atherosclerosis==</div></td></tr>
</table>
Lakshmi Gopalakrishnan
https://www.wikidoc.org/index.php?title=Aortic_sclerosis_pathophysiology&diff=641260&oldid=prev
Lakshmi Gopalakrishnan at 17:14, 11 April 2012
2012-04-11T17:14:04Z
<p></p>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Aortic sclerosis is '''''non-obstructive degeneration''''' of the aortic valve developed consequently to [[calcification of the aortic valve]] and macrophage accumulation which is dependent on the synthesis of osteopontin protein.<ref name="pmid7554197">{{cite journal |author=O'Brien KD, Kuusisto J, Reichenbach DD, Ferguson M, Giachelli C, Alpers CE, Otto CM |title=Osteopontin is expressed in human aortic valvular lesions |journal=[[Circulation]] |volume=92 |issue=8 |pages=2163–8 |year=1995 |month=October |pmid=7554197 |doi= |url=http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=7554197 |accessdate=2012-04-11}}</ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Aortic sclerosis is '''''non-obstructive degeneration''''' of the aortic valve developed consequently to [[calcification of the aortic valve]] and macrophage accumulation which is dependent on the synthesis of osteopontin protein.<ref name="pmid7554197">{{cite journal |author=O'Brien KD, Kuusisto J, Reichenbach DD, Ferguson M, Giachelli C, Alpers CE, Otto CM |title=Osteopontin is expressed in human aortic valvular lesions |journal=[[Circulation]] |volume=92 |issue=8 |pages=2163–8 |year=1995 |month=October |pmid=7554197 |doi= |url=http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=7554197 |accessdate=2012-04-11}}</ref></div></td></tr>
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<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">*Disturbances in mineral metabolism such as higher serum phosphate concentration has shown to contribute to the development of [[aortic sclerosis]].<ref name="pmid21737022">{{cite journal |author=Linefsky JP, O'Brien KD, Katz R, de Boer IH, Barasch E, Jenny NS, Siscovick DS, Kestenbaum B |title=Association of serum phosphate levels with aortic valve sclerosis and annular calcification: the cardiovascular health study |journal=[[Journal of the American College of Cardiology]] |volume=58 |issue=3 |pages=291–7 |year=2011 |month=July |pmid=21737022 |doi=10.1016/j.jacc.2010.11.073 |url=http://linkinghub.elsevier.com/retrieve/pii/S0735-1097(11)01488-4 |accessdate=2012-04-11}}</ref><ref name="pmid19073826">{{cite journal |author=Adeney KL, Siscovick DS, Ix JH, Seliger SL, Shlipak MG, Jenny NS, Kestenbaum BR |title=Association of serum phosphate with vascular and valvular calcification in moderate CKD |journal=[[Journal of the American Society of Nephrology : JASN]] |volume=20 |issue=2 |pages=381–7 |year=2009 |month=February |pmid=19073826 |pmc=2637048 |doi=10.1681/ASN.2008040349 |url=http://jasn.asnjournals.org/cgi/pmidlookup?view=long&pmid=19073826 |accessdate=2012-04-11}}</ref></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Aortic Sclerosis & Atherosclerosis==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Aortic Sclerosis & Atherosclerosis==</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>====[[Aortic sclerosis natural history#Progression to Aortic Stenosis|Progression to Aortic Stenosis]]====</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>====[[Aortic sclerosis natural history#Progression to Aortic Stenosis|Progression to Aortic Stenosis]]====</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==References==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==References==</div></td></tr>
</table>
Lakshmi Gopalakrishnan
https://www.wikidoc.org/index.php?title=Aortic_sclerosis_pathophysiology&diff=641259&oldid=prev
Lakshmi Gopalakrishnan at 17:11, 11 April 2012
2012-04-11T17:11:59Z
<p></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<tr class="diff-title" lang="en">
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 17:11, 11 April 2012</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Aortic sclerosis is '''''non-obstructive degeneration''''' of the aortic valve developed consequently to [[calcification of the aortic valve]] and macrophage accumulation which is dependent on the synthesis of osteopontin protein.<ref name="pmid7554197">{{cite journal |author=O'Brien KD, Kuusisto J, Reichenbach DD, Ferguson M, Giachelli C, Alpers CE, Otto CM |title=Osteopontin is expressed in human aortic valvular lesions |journal=[[Circulation]] |volume=92 |issue=8 |pages=2163–8 |year=1995 |month=October |pmid=7554197 |doi= |url=http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=7554197 |accessdate=2012-04-11}}</ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Aortic sclerosis is '''''non-obstructive degeneration''''' of the aortic valve developed consequently to [[calcification of the aortic valve]] and macrophage accumulation which is dependent on the synthesis of osteopontin protein.<ref name="pmid7554197">{{cite journal |author=O'Brien KD, Kuusisto J, Reichenbach DD, Ferguson M, Giachelli C, Alpers CE, Otto CM |title=Osteopontin is expressed in human aortic valvular lesions |journal=[[Circulation]] |volume=92 |issue=8 |pages=2163–8 |year=1995 |month=October |pmid=7554197 |doi= |url=http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=7554197 |accessdate=2012-04-11}}</ref></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">==Aortic Sclerosis & Atherosclerosis==</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">====[[Aortic sclerosis risk factors#Aortic Sclerosis as a Risk Factor for Coronary Artery Disease|Aortic Sclerosis as a Risk Factor for Coronary Artery Disease]]====</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">====[[Aortic sclerosis natural history#Progression to Aortic Stenosis|Progression to Aortic Stenosis]]====</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==References==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==References==</div></td></tr>
</table>
Lakshmi Gopalakrishnan
https://www.wikidoc.org/index.php?title=Aortic_sclerosis_pathophysiology&diff=641246&oldid=prev
Lakshmi Gopalakrishnan at 16:49, 11 April 2012
2012-04-11T16:49:02Z
<p></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<col class="diff-marker" />
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<tr class="diff-title" lang="en">
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 16:49, 11 April 2012</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l4">Line 4:</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Overview==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Overview==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Calcific aortic valve disease includes both [[aortic sclerosis]] and [[aortic stenosis]]. </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[</ins>Calcific aortic valve disease<ins style="font-weight: bold; text-decoration: none;">]] </ins>includes both [[aortic sclerosis]] and [[aortic stenosis]].<ins style="font-weight: bold; text-decoration: none;"><ref name="pmid16709942">{{cite journal |author=O'Brien KD |title=Pathogenesis of calcific aortic valve disease: a disease process comes of age (and a good deal more) |journal=[[Arteriosclerosis, Thrombosis, and Vascular Biology]] |volume=26 |issue=8 |pages=1721–8 |year=2006 |month=August |pmid=16709942 |doi=10.1161/01.ATV.0000227513.13697.ac |url=http://atvb.ahajournals.org/cgi/pmidlookup?view=long&pmid=16709942 |accessdate=2012-04-11}}</ref> </ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>In patients with calcific aortic valve disease, microscopic examination reveals lipoprotein accumulation,<ref name="pmid8624774">{{cite journal |author=O'Brien KD, Reichenbach DD, Marcovina SM, Kuusisto J, Alpers CE, Otto CM |title=Apolipoproteins B, (a), and E accumulate in the morphologically early lesion of 'degenerative' valvular aortic stenosis |journal=[[Arteriosclerosis, Thrombosis, and Vascular Biology]] |volume=16 |issue=4 |pages=523–32 |year=1996 |month=April |pmid=8624774 |doi= |url=http://atvb.ahajournals.org/cgi/pmidlookup?view=long&pmid=8624774 |accessdate=2012-04-11}}</ref> macrophage and T-cellular infiltration,<ref name="pmid8144784">{{cite journal |author=Olsson M, Dalsgaard CJ, Haegerstrand A, Rosenqvist M, Rydén L, Nilsson J |title=Accumulation of T lymphocytes and expression of interleukin-2 receptors in nonrheumatic stenotic aortic valves |journal=[[Journal of the American College of Cardiology]] |volume=23 |issue=5 |pages=1162–70 |year=1994 |month=April |pmid=8144784 |doi= |url=http://linkinghub.elsevier.com/retrieve/pii/0735-1097(94)90606-8 |accessdate=2012-04-11}}</ref> basement membrane disruption and extracellular matrix formation that lead to progressive thickening of the aortic valve.<ref name="pmid15967862">{{cite journal |author=Freeman RV, Otto CM |title=Spectrum of calcific aortic valve disease: pathogenesis, disease progression, and treatment strategies |journal=[[Circulation]] |volume=111 |issue=24 |pages=3316–26 |year=2005 |month=June |pmid=15967862 |doi=10.1161/CIRCULATIONAHA.104.486738 |url=http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=15967862 |accessdate=2012-04-10}}</ref><ref name="pmid7519131">{{cite journal |author=Otto CM, Kuusisto J, Reichenbach DD, Gown AM, O'Brien KD |title=Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies |journal=[[Circulation]] |volume=90 |issue=2 |pages=844–53 |year=1994 |month=August |pmid=7519131 |doi= |url=http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=7519131 |accessdate=2012-04-11}}</ref><ref name="pmid16709942">{{cite journal |author=O'Brien KD |title=Pathogenesis of calcific aortic valve disease: a disease process comes of age (and a good deal more) |journal=[[Arteriosclerosis, Thrombosis, and Vascular Biology]] |volume=26 |issue=8 |pages=1721–8 |year=2006 |month=August |pmid=16709942 |doi=10.1161/01.ATV.0000227513.13697.ac |url=http://atvb.ahajournals.org/cgi/pmidlookup?view=long&pmid=16709942 |accessdate=2012-04-11}}</ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>In patients with calcific aortic valve disease, microscopic examination reveals lipoprotein accumulation,<ref name="pmid8624774">{{cite journal |author=O'Brien KD, Reichenbach DD, Marcovina SM, Kuusisto J, Alpers CE, Otto CM |title=Apolipoproteins B, (a), and E accumulate in the morphologically early lesion of 'degenerative' valvular aortic stenosis |journal=[[Arteriosclerosis, Thrombosis, and Vascular Biology]] |volume=16 |issue=4 |pages=523–32 |year=1996 |month=April |pmid=8624774 |doi= |url=http://atvb.ahajournals.org/cgi/pmidlookup?view=long&pmid=8624774 |accessdate=2012-04-11}}</ref> macrophage and T-cellular infiltration,<ref name="pmid8144784">{{cite journal |author=Olsson M, Dalsgaard CJ, Haegerstrand A, Rosenqvist M, Rydén L, Nilsson J |title=Accumulation of T lymphocytes and expression of interleukin-2 receptors in nonrheumatic stenotic aortic valves |journal=[[Journal of the American College of Cardiology]] |volume=23 |issue=5 |pages=1162–70 |year=1994 |month=April |pmid=8144784 |doi= |url=http://linkinghub.elsevier.com/retrieve/pii/0735-1097(94)90606-8 |accessdate=2012-04-11}}</ref> basement membrane disruption and extracellular matrix formation that lead to progressive thickening of the aortic valve.<ref name="pmid15967862">{{cite journal |author=Freeman RV, Otto CM |title=Spectrum of calcific aortic valve disease: pathogenesis, disease progression, and treatment strategies |journal=[[Circulation]] |volume=111 |issue=24 |pages=3316–26 |year=2005 |month=June |pmid=15967862 |doi=10.1161/CIRCULATIONAHA.104.486738 |url=http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=15967862 |accessdate=2012-04-10}}</ref><ref name="pmid7519131">{{cite journal |author=Otto CM, Kuusisto J, Reichenbach DD, Gown AM, O'Brien KD |title=Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies |journal=[[Circulation]] |volume=90 |issue=2 |pages=844–53 |year=1994 |month=August |pmid=7519131 |doi= |url=http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=7519131 |accessdate=2012-04-11}}</ref><ref name="pmid16709942">{{cite journal |author=O'Brien KD |title=Pathogenesis of calcific aortic valve disease: a disease process comes of age (and a good deal more) |journal=[[Arteriosclerosis, Thrombosis, and Vascular Biology]] |volume=26 |issue=8 |pages=1721–8 |year=2006 |month=August |pmid=16709942 |doi=10.1161/01.ATV.0000227513.13697.ac |url=http://atvb.ahajournals.org/cgi/pmidlookup?view=long&pmid=16709942 |accessdate=2012-04-11}}</ref></div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>:#Regions of the fibrosa adjacent to these lesions were characterized by thickening and by protein, lipid, and calcium accumulation</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>:#Regions of the fibrosa adjacent to these lesions were characterized by thickening and by protein, lipid, and calcium accumulation</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>*Aortic sclerosis is '''''non-obstructive degeneration''''' of the aortic valve developed consequently to calcification of the aortic valve and macrophage accumulation which is dependent on the synthesis of osteopontin protein.<ref name="pmid7554197">{{cite journal |author=O'Brien KD, Kuusisto J, Reichenbach DD, Ferguson M, Giachelli C, Alpers CE, Otto CM |title=Osteopontin is expressed in human aortic valvular lesions |journal=[[Circulation]] |volume=92 |issue=8 |pages=2163–8 |year=1995 |month=October |pmid=7554197 |doi= |url=http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=7554197 |accessdate=2012-04-11}}</ref></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>*Aortic sclerosis is '''''non-obstructive degeneration''''' of the aortic valve developed consequently to <ins style="font-weight: bold; text-decoration: none;">[[</ins>calcification of the aortic valve<ins style="font-weight: bold; text-decoration: none;">]] </ins>and macrophage accumulation which is dependent on the synthesis of osteopontin protein.<ref name="pmid7554197">{{cite journal |author=O'Brien KD, Kuusisto J, Reichenbach DD, Ferguson M, Giachelli C, Alpers CE, Otto CM |title=Osteopontin is expressed in human aortic valvular lesions |journal=[[Circulation]] |volume=92 |issue=8 |pages=2163–8 |year=1995 |month=October |pmid=7554197 |doi= |url=http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=7554197 |accessdate=2012-04-11}}</ref></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==References==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==References==</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{WS}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{WS}}</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Category:Disease]]</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Category:Cardiology]]</ins></div></td></tr>
</table>
Lakshmi Gopalakrishnan
https://www.wikidoc.org/index.php?title=Aortic_sclerosis_pathophysiology&diff=641236&oldid=prev
Lakshmi Gopalakrishnan: /* Overview */
2012-04-11T16:40:29Z
<p><span dir="auto"><span class="autocomment">Overview</span></span></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
<col class="diff-marker" />
<col class="diff-content" />
<col class="diff-marker" />
<col class="diff-content" />
<tr class="diff-title" lang="en">
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 16:40, 11 April 2012</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Overview==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Overview==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Microscopic changes reveal </del>lipoprotein accumulation,<ref name="pmid8624774">{{cite journal |author=O'Brien KD, Reichenbach DD, Marcovina SM, Kuusisto J, Alpers CE, Otto CM |title=Apolipoproteins B, (a), and E accumulate in the morphologically early lesion of 'degenerative' valvular aortic stenosis |journal=[[Arteriosclerosis, Thrombosis, and Vascular Biology]] |volume=16 |issue=4 |pages=523–32 |year=1996 |month=April |pmid=8624774 |doi= |url=http://atvb.ahajournals.org/cgi/pmidlookup?view=long&pmid=8624774 |accessdate=2012-04-11}}</ref> macrophage and T-cellular infiltration,<ref name="pmid8144784">{{cite journal |author=Olsson M, Dalsgaard CJ, Haegerstrand A, Rosenqvist M, Rydén L, Nilsson J |title=Accumulation of T lymphocytes and expression of interleukin-2 receptors in nonrheumatic stenotic aortic valves |journal=[[Journal of the American College of Cardiology]] |volume=23 |issue=5 |pages=1162–70 |year=1994 |month=April |pmid=8144784 |doi= |url=http://linkinghub.elsevier.com/retrieve/pii/0735-1097(94)90606-8 |accessdate=2012-04-11}}</ref> basement membrane disruption and extracellular matrix formation that <del style="font-weight: bold; text-decoration: none;">cause </del>progressive thickening of the aortic valve.<ref name="pmid15967862">{{cite journal |author=Freeman RV, Otto CM |title=Spectrum of calcific aortic valve disease: pathogenesis, disease progression, and treatment strategies |journal=[[Circulation]] |volume=111 |issue=24 |pages=3316–26 |year=2005 |month=June |pmid=15967862 |doi=10.1161/CIRCULATIONAHA.104.486738 |url=http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=15967862 |accessdate=2012-04-10}}</ref><ref name="pmid7519131">{{cite journal |author=Otto CM, Kuusisto J, Reichenbach DD, Gown AM, O'Brien KD |title=Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies |journal=[[Circulation]] |volume=90 |issue=2 |pages=844–53 |year=1994 |month=August |pmid=7519131 |doi= |url=http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=7519131 |accessdate=2012-04-11}}</ref></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Calcific aortic valve disease includes both [[aortic sclerosis]] and [[aortic stenosis]]. </ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">In patients with calcific aortic valve disease, microscopic examination reveals </ins>lipoprotein accumulation,<ref name="pmid8624774">{{cite journal |author=O'Brien KD, Reichenbach DD, Marcovina SM, Kuusisto J, Alpers CE, Otto CM |title=Apolipoproteins B, (a), and E accumulate in the morphologically early lesion of 'degenerative' valvular aortic stenosis |journal=[[Arteriosclerosis, Thrombosis, and Vascular Biology]] |volume=16 |issue=4 |pages=523–32 |year=1996 |month=April |pmid=8624774 |doi= |url=http://atvb.ahajournals.org/cgi/pmidlookup?view=long&pmid=8624774 |accessdate=2012-04-11}}</ref> macrophage and T-cellular infiltration,<ref name="pmid8144784">{{cite journal |author=Olsson M, Dalsgaard CJ, Haegerstrand A, Rosenqvist M, Rydén L, Nilsson J |title=Accumulation of T lymphocytes and expression of interleukin-2 receptors in nonrheumatic stenotic aortic valves |journal=[[Journal of the American College of Cardiology]] |volume=23 |issue=5 |pages=1162–70 |year=1994 |month=April |pmid=8144784 |doi= |url=http://linkinghub.elsevier.com/retrieve/pii/0735-1097(94)90606-8 |accessdate=2012-04-11}}</ref> basement membrane disruption and extracellular matrix formation that <ins style="font-weight: bold; text-decoration: none;">lead to </ins>progressive thickening of the aortic valve.<ref name="pmid15967862">{{cite journal |author=Freeman RV, Otto CM |title=Spectrum of calcific aortic valve disease: pathogenesis, disease progression, and treatment strategies |journal=[[Circulation]] |volume=111 |issue=24 |pages=3316–26 |year=2005 |month=June |pmid=15967862 |doi=10.1161/CIRCULATIONAHA.104.486738 |url=http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=15967862 |accessdate=2012-04-10}}</ref><ref name="pmid7519131">{{cite journal |author=Otto CM, Kuusisto J, Reichenbach DD, Gown AM, O'Brien KD |title=Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies |journal=[[Circulation]] |volume=90 |issue=2 |pages=844–53 |year=1994 |month=August |pmid=7519131 |doi= |url=http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=7519131 <ins style="font-weight: bold; text-decoration: none;">|accessdate=2012-04-11}}</ref><ref name="pmid16709942">{{cite journal |author=O'Brien KD |title=Pathogenesis of calcific aortic valve disease: a disease process comes of age (and a good deal more) |journal=[[Arteriosclerosis, Thrombosis, and Vascular Biology]] |volume=26 |issue=8 |pages=1721–8 |year=2006 |month=August |pmid=16709942 |doi=10.1161/01.ATV.0000227513.13697.ac |url=http://atvb.ahajournals.org/cgi/pmidlookup?view=long&pmid=16709942 </ins>|accessdate=2012-04-11}}</ref></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Pathophysiology==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Pathophysiology==</div></td></tr>
</table>
Lakshmi Gopalakrishnan
https://www.wikidoc.org/index.php?title=Aortic_sclerosis_pathophysiology&diff=641233&oldid=prev
Lakshmi Gopalakrishnan: /* Overview */
2012-04-11T16:38:01Z
<p><span dir="auto"><span class="autocomment">Overview</span></span></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<col class="diff-marker" />
<col class="diff-content" />
<tr class="diff-title" lang="en">
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 16:38, 11 April 2012</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Overview==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Overview==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Microscopic changes reveal lipoprotein accumulation, macrophage and T-cellular infiltration, basement membrane disruption and extracellular matrix formation that cause progressive thickening of the aortic valve.<ref name="pmid15967862">{{cite journal |author=Freeman RV, Otto CM |title=Spectrum of calcific aortic valve disease: pathogenesis, disease progression, and treatment strategies |journal=[[Circulation]] |volume=111 |issue=24 |pages=3316–26 |year=2005 |month=June |pmid=15967862 |doi=10.1161/CIRCULATIONAHA.104.486738 |url=http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=15967862 |accessdate=2012-04-10}}</ref><ref name="pmid7519131">{{cite journal |author=Otto CM, Kuusisto J, Reichenbach DD, Gown AM, O'Brien KD |title=Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies |journal=[[Circulation]] |volume=90 |issue=2 |pages=844–53 |year=1994 |month=August |pmid=7519131 |doi= |url=http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=7519131 |accessdate=2012-04-11}}</ref></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Microscopic changes reveal lipoprotein accumulation,<ins style="font-weight: bold; text-decoration: none;"><ref name="pmid8624774">{{cite journal |author=O'Brien KD, Reichenbach DD, Marcovina SM, Kuusisto J, Alpers CE, Otto CM |title=Apolipoproteins B, (a), and E accumulate in the morphologically early lesion of 'degenerative' valvular aortic stenosis |journal=[[Arteriosclerosis, Thrombosis, and Vascular Biology]] |volume=16 |issue=4 |pages=523–32 |year=1996 |month=April |pmid=8624774 |doi= |url=http://atvb.ahajournals.org/cgi/pmidlookup?view=long&pmid=8624774 |accessdate=2012-04-11}}</ref> </ins>macrophage and T-cellular infiltration,<ins style="font-weight: bold; text-decoration: none;"><ref name="pmid8144784">{{cite journal |author=Olsson M, Dalsgaard CJ, Haegerstrand A, Rosenqvist M, Rydén L, Nilsson J |title=Accumulation of T lymphocytes and expression of interleukin-2 receptors in nonrheumatic stenotic aortic valves |journal=[[Journal of the American College of Cardiology]] |volume=23 |issue=5 |pages=1162–70 |year=1994 |month=April |pmid=8144784 |doi= |url=http://linkinghub.elsevier.com/retrieve/pii/0735-1097(94)90606-8 |accessdate=2012-04-11}}</ref> </ins>basement membrane disruption and extracellular matrix formation that cause progressive thickening of the aortic valve.<ref name="pmid15967862">{{cite journal |author=Freeman RV, Otto CM |title=Spectrum of calcific aortic valve disease: pathogenesis, disease progression, and treatment strategies |journal=[[Circulation]] |volume=111 |issue=24 |pages=3316–26 |year=2005 |month=June |pmid=15967862 |doi=10.1161/CIRCULATIONAHA.104.486738 |url=http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=15967862 |accessdate=2012-04-10}}</ref><ref name="pmid7519131">{{cite journal |author=Otto CM, Kuusisto J, Reichenbach DD, Gown AM, O'Brien KD |title=Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies |journal=[[Circulation]] |volume=90 |issue=2 |pages=844–53 |year=1994 |month=August |pmid=7519131 |doi= |url=http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=7519131 |accessdate=2012-04-11}}</ref></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Pathophysiology==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Pathophysiology==</div></td></tr>
</table>
Lakshmi Gopalakrishnan
https://www.wikidoc.org/index.php?title=Aortic_sclerosis_pathophysiology&diff=641231&oldid=prev
Lakshmi Gopalakrishnan: /* Pathophysiology */
2012-04-11T16:33:53Z
<p><span dir="auto"><span class="autocomment">Pathophysiology</span></span></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<col class="diff-marker" />
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 16:33, 11 April 2012</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Pathophysiology==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Pathophysiology==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Otto et al,<ref name="pmid7519131">{{cite journal |author=Otto CM, Kuusisto J, Reichenbach DD, Gown AM, O'Brien KD |title=Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies |journal=[[Circulation]] |volume=90 |issue=2 |pages=844–53 |year=1994 |month=August |pmid=7519131 |doi= |url=http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=7519131 |accessdate=2012-04-11}}</ref> demonstrated the following histological characteristics observed in patients with [[aortic sclerosis]]:</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Otto et al,<ref name="pmid7519131">{{cite journal |author=Otto CM, Kuusisto J, Reichenbach DD, Gown AM, O'Brien KD |title=Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies |journal=[[Circulation]] |volume=90 |issue=2 |pages=844–53 |year=1994 |month=August |pmid=7519131 |doi= |url=http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=7519131 |accessdate=2012-04-11}}</ref> demonstrated the following histological characteristics observed in patients with [[aortic sclerosis]]:</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>:#Subendothelial thickening on the aortic side of the leaflet, between the basement membrane and elastic lamina<del style="font-weight: bold; text-decoration: none;">,</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>:#Subendothelial thickening on the aortic side of the leaflet, between the basement membrane and elastic lamina</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>:#Presence of large amounts of intracellular and extracellular neutral lipids and fine, stippled mineralization<del style="font-weight: bold; text-decoration: none;">, and</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>:#Presence of large amounts of intracellular and extracellular neutral lipids and fine, stippled mineralization</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>:#Disruption of the basement membrane overlying the lesion<del style="font-weight: bold; text-decoration: none;">. </del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>:#Disruption of the basement membrane overlying the lesion</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>:#Regions of the fibrosa adjacent to these lesions were characterized by thickening and by protein, lipid, and calcium accumulation<del style="font-weight: bold; text-decoration: none;">.</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>:#Regions of the fibrosa adjacent to these lesions were characterized by thickening and by protein, lipid, and calcium accumulation</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Aortic sclerosis is '''''non-obstructive degeneration''''' of the aortic valve developed consequently to calcification of the aortic valve and macrophage accumulation which is dependent on the synthesis of osteopontin protein.<ref name="pmid7554197">{{cite journal |author=O'Brien KD, Kuusisto J, Reichenbach DD, Ferguson M, Giachelli C, Alpers CE, Otto CM |title=Osteopontin is expressed in human aortic valvular lesions |journal=[[Circulation]] |volume=92 |issue=8 |pages=2163–8 |year=1995 |month=October |pmid=7554197 |doi= |url=http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=7554197 |accessdate=2012-04-11}}</ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Aortic sclerosis is '''''non-obstructive degeneration''''' of the aortic valve developed consequently to calcification of the aortic valve and macrophage accumulation which is dependent on the synthesis of osteopontin protein.<ref name="pmid7554197">{{cite journal |author=O'Brien KD, Kuusisto J, Reichenbach DD, Ferguson M, Giachelli C, Alpers CE, Otto CM |title=Osteopontin is expressed in human aortic valvular lesions |journal=[[Circulation]] |volume=92 |issue=8 |pages=2163–8 |year=1995 |month=October |pmid=7554197 |doi= |url=http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=7554197 |accessdate=2012-04-11}}</ref></div></td></tr>
</table>
Lakshmi Gopalakrishnan
https://www.wikidoc.org/index.php?title=Aortic_sclerosis_pathophysiology&diff=641230&oldid=prev
Lakshmi Gopalakrishnan at 16:33, 11 April 2012
2012-04-11T16:33:28Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 16:33, 11 April 2012</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>:#Disruption of the basement membrane overlying the lesion. </div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>:#Disruption of the basement membrane overlying the lesion. </div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>:#Regions of the fibrosa adjacent to these lesions were characterized by thickening and by protein, lipid, and calcium accumulation.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>:#Regions of the fibrosa adjacent to these lesions were characterized by thickening and by protein, lipid, and calcium accumulation.</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">*Aortic sclerosis is '''''non-obstructive degeneration''''' of the aortic valve developed consequently to calcification of the aortic valve and macrophage accumulation which is dependent on the synthesis of osteopontin protein.<ref name="pmid7554197">{{cite journal |author=O'Brien KD, Kuusisto J, Reichenbach DD, Ferguson M, Giachelli C, Alpers CE, Otto CM |title=Osteopontin is expressed in human aortic valvular lesions |journal=[[Circulation]] |volume=92 |issue=8 |pages=2163–8 |year=1995 |month=October |pmid=7554197 |doi= |url=http://circ.ahajournals.org/cgi/pmidlookup?view=long&pmid=7554197 |accessdate=2012-04-11}}</ref></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==References==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==References==</div></td></tr>
</table>
Lakshmi Gopalakrishnan