Antrafenine

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Antrafenine
File:Antrafenine.png
Clinical data
Routes of
administration		oral
Pharmacokinetic data
Metabolismhepatic
Excretionrenal
Identifiers
CAS Number
PubChem CID
E number{{#property:P628}}
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Chemical and physical data
FormulaC30H26F6N4O2
Molar mass588.543 g/mol


Antrafenine (Stakane) is a piperazine derivative drug invented in 1979. [1] It acts as an analgesic and anti-inflammatory drug with similar efficacy to naproxen,[2] but is not widely used as it has largely been replaced by newer drugs.


References

  1. ↑ Manoury PM, Dumas AP, Najer H, Branceni D, Prouteau M, Lefevre-Borg FM. Synthesis and analgesic activities of some (4-substituted phenyl-1-piperazinyl)alkyl 2-aminobenzoates and 2-aminonicotinates. Journal of Medicinal Chemistry. 1979 May;22(5):554-9.
  2. ↑ Leatham PA, Bird HA, Wright V, Seymour D, Gordon A. A double blind study of antrafenine, naproxen and placebo in osteoarthrosis. European Journal of Rheumatology and Inflammation. 1983;6(2):209-11.
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