Anti-citrullinated protein antibody

Jump to navigation Jump to search
The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.
Anti-citrullinated protein antibody

WikiDoc Resources for Anti-citrullinated protein antibody

Articles

Most recent articles on Anti-citrullinated protein antibody

Most cited articles on Anti-citrullinated protein antibody

Review articles on Anti-citrullinated protein antibody

Articles on Anti-citrullinated protein antibody in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Anti-citrullinated protein antibody

Images of Anti-citrullinated protein antibody

Photos of Anti-citrullinated protein antibody

Podcasts & MP3s on Anti-citrullinated protein antibody

Videos on Anti-citrullinated protein antibody

Evidence Based Medicine

Cochrane Collaboration on Anti-citrullinated protein antibody

Bandolier on Anti-citrullinated protein antibody

TRIP on Anti-citrullinated protein antibody

Clinical Trials

Ongoing Trials on Anti-citrullinated protein antibody at Clinical Trials.gov

Trial results on Anti-citrullinated protein antibody

Clinical Trials on Anti-citrullinated protein antibody at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Anti-citrullinated protein antibody

NICE Guidance on Anti-citrullinated protein antibody

NHS PRODIGY Guidance

FDA on Anti-citrullinated protein antibody

CDC on Anti-citrullinated protein antibody

Books

Books on Anti-citrullinated protein antibody

News

Anti-citrullinated protein antibody in the news

Be alerted to news on Anti-citrullinated protein antibody

News trends on Anti-citrullinated protein antibody

Commentary

Blogs on Anti-citrullinated protein antibody

Definitions

Definitions of Anti-citrullinated protein antibody

Patient Resources / Community

Patient resources on Anti-citrullinated protein antibody

Discussion groups on Anti-citrullinated protein antibody

Patient Handouts on Anti-citrullinated protein antibody

Directions to Hospitals Treating Anti-citrullinated protein antibody

Risk calculators and risk factors for Anti-citrullinated protein antibody

Healthcare Provider Resources

Symptoms of Anti-citrullinated protein antibody

Causes & Risk Factors for Anti-citrullinated protein antibody

Diagnostic studies for Anti-citrullinated protein antibody

Treatment of Anti-citrullinated protein antibody

Continuing Medical Education (CME)

CME Programs on Anti-citrullinated protein antibody

International

Anti-citrullinated protein antibody en Espanol

Anti-citrullinated protein antibody en Francais

Business

Anti-citrullinated protein antibody in the Marketplace

Patents on Anti-citrullinated protein antibody

Experimental / Informatics

List of terms related to Anti-citrullinated protein antibody

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Anti-citrullinated protein antibodies (ACPA) or anti-cyclic citrullinated protein antibodies (anti-CCP) are autoantibodies (antibodies against human tissues) frequently detected in rheumatoid arthritis. The main epitope for these antibodies is filaggrin, and there is cross-reactivity between ACPA and anti-keratin and anti-perinuclear factor.[1] In a comparative study, various detection kits had a sensitivity between 69.6% and 77.5% and a specificity between 87.8% and 96.4%.[2] Given that ACPA is more specific than rheumatoid factor, it is used to distinguish various causes of arthritis.[3]

References

  1. Schellekens GA, de Jong BA, van den Hoogen FH, van de Putte LB, van Venrooij WJ (1998). "Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies". J. Clin. Invest. 101 (1): 273–81. doi:10.1172/JCI1316. PMID 9421490. Unknown parameter |month= ignored (help) PMC 508564
  2. Coenen D, Verschueren P, Westhovens R, Bossuyt X (2007). "Technical and diagnostic performance of 6 assays for the measurement of citrullinated protein/peptide antibodies in the diagnosis of rheumatoid arthritis". Clin. Chem. 53 (3): 498–504. doi:10.1373/clinchem.2006.078063. PMID 17259232. Unknown parameter |month= ignored (help)
  3. Avouac J, Gossec L, Dougados M (2006). "Diagnostic and predictive value of anti-cyclic citrullinated protein antibodies in rheumatoid arthritis: a systematic literature review". Ann. Rheum. Dis. 65 (7): 845–51. doi:10.1136/ard.2006.051391. PMID 16606649. Unknown parameter |month= ignored (help)


Template:Autoantibodies


Template:WikiDoc Sources