Ankylosing spondylitis pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]

Overview

Ankylosing spondylitis (AS), a spondyloarthropathy, is a chronic, multisystem inflammatory disorder involving primarily the sacroiliac (SI) joints and the axial skeleton. The outcome in patients with a spondyloarthropathy, including AS, is generally compared with that in patients with a disease such as rheumatoid arthritis.Mostly the joints where the spine joins the pelvis are also affected.Back pain is one of the most prominent symptoms of the ankylosing spondylitis (AS) which is intermittent in nature.Stiffness in the affected joints gets worse.It is believed that both the combination of genetic and environmental factors play an important role in the pathogenesis of ankylosing spondylitis (AS) and the underlying etiology is believed to be autoimmune or autoinflammatory.

Pathophysiology

Pathogenesis[1]

Genetics

Evidence of Other Genetic Associations in Ankylosing spondylitis (AS):

  • There is very significant evidence to prove that other genetic conditions also act to determine which the patients have a increased susceptibility in developing the ankylosing spondylitis (AS), and studies show that HLA-B27+ patients who have a first-degree relative with ankylosing spondylitis(AS) have increased rates of disease development 6–16 times more than those without such a family history with ankylosing spondylitis.[15][16][17][18][19]
  • Evenmore, the radiographic severity tested with the Bath AS radiographic index has a heritability rate index of 0.62.[20][21]

HLA-B27 in the pathogenesis of ankylosing spondylitis

Hypothesis Pathogenesis
Arthritogenic peptides Immunological (adaptive immunity)
Heavy chain of aberrant surface Immunological (innate immunity)
Abnormal protein folding Intracellular (innate immunity)
Enhanced microbial survival Intracellular (innate immunity)

Cytokine and Enzymes Effect on AS

  • The immunopathogenesis of ankylosing spondylitis(AS) is suspected to involve upregulation of proinflammatory cytokines like especially tumor necrosis factor–a(TNF-a) which is more increased than others in patients with ankylosing spondylitis(AS).[22]
  • Increased serum levels of IL-6 and IL-17 shows associate with the development and progression of ankylosing spondylitis.[23][24][25]

Gross Pathology

On gross pathology, The following are the characteristic findings of ankylosing spondylitis(AS).

Spine with spondylitis ankylosans

https://commons.wikimedia.org/wiki/File:0510_Spondylitis_ankylosans_(morbus_bechterew)_anagoria.JPG#/media/File:0510_Spondylitis_ankylosans_(morbus_bechterew)_anagoria.JPG

Anterior flexion in ankylosing spondylitis

Anterior flexion in AS
By Leonard Trask - https://commons.wikimedia.org/wiki/File:AS_trask.jpg, Public Domain, https://commons.wikimedia.org/w/index.php?curid=52791160

Microscopic Pathology

References

  1. Shamji, Mohammed F.; Bafaquh, Mohammed; Tsai, Eve (2008). "The pathogenesis of ankylosing spondylitis". Neurosurgical Focus. 24 (1): E3. doi:10.3171/FOC/2008/24/1/E3. ISSN 1092-0684.
  2. Fiorillo MT, Greco G, Maragno M, Potolicchio I, Monizio A, Dupuis ML, Sorrentino R (August 1998). "The naturally occurring polymorphism Asp116-->His116, differentiating the ankylosing spondylitis-associated HLA-B*2705 from the non-associated HLA-B*2709 subtype, influences peptide-specific CD8 T cell recognition". Eur. J. Immunol. 28 (8): 2508–16. PMID 9710228.
  3. Fiorillo MT, Greco G, Maragno M, Potolicchio I, Monizio A, Dupuis ML, Sorrentino R (August 1998). "The naturally occurring polymorphism Asp116-->His116, differentiating the ankylosing spondylitis-associated HLA-B*2705 from the non-associated HLA-B*2709 subtype, influences peptide-specific CD8 T cell recognition". Eur. J. Immunol. 28 (8): 2508–16. PMID 9710228.
  4. Hülsmeyer M, Fiorillo MT, Bettosini F, Sorrentino R, Saenger W, Ziegler A, Uchanska-Ziegler B (January 2004). "Dual, HLA-B27 subtype-dependent conformation of a self-peptide". J. Exp. Med. 199 (2): 271–81. doi:10.1084/jem.20031690. PMC 2211767. PMID 14734527.
  5. Benjamin R, Parham P (April 1990). "Guilt by association: HLA-B27 and ankylosing spondylitis". Immunol. Today. 11 (4): 137–42. PMID 2187471.
  6. Hülsmeyer M, Fiorillo MT, Bettosini F, Sorrentino R, Saenger W, Ziegler A, Uchanska-Ziegler B (January 2004). "Dual, HLA-B27 subtype-dependent conformation of a self-peptide". J. Exp. Med. 199 (2): 271–81. doi:10.1084/jem.20031690. PMC 2211767. PMID 14734527.
  7. Del Porto P, D'Amato M, Fiorillo MT, Tuosto L, Piccolella E, Sorrentino R (October 1994). "Identification of a novel HLA-B27 subtype by restriction analysis of a cytotoxic gamma delta T cell clone". J. Immunol. 153 (7): 3093–100. PMID 8089488.
  8. Hülsmeyer M, Fiorillo MT, Bettosini F, Sorrentino R, Saenger W, Ziegler A, Uchanska-Ziegler B (January 2004). "Dual, HLA-B27 subtype-dependent conformation of a self-peptide". J. Exp. Med. 199 (2): 271–81. doi:10.1084/jem.20031690. PMC 2211767. PMID 14734527.
  9. Fiorillo MT, Meadows L, D'Amato M, Shabanowitz J, Hunt DF, Appella E, Sorrentino R (February 1997). "Susceptibility to ankylosing spondylitis correlates with the C-terminal residue of peptides presented by various HLA-B27 subtypes". Eur. J. Immunol. 27 (2): 368–73. doi:10.1002/eji.1830270205. PMID 9045906.
  10. D'Amato M, Fiorillo MT, Carcassi C, Mathieu A, Zuccarelli A, Bitti PP, Tosi R, Sorrentino R (November 1995). "Relevance of residue 116 of HLA-B27 in determining susceptibility to ankylosing spondylitis". Eur. J. Immunol. 25 (11): 3199–201. doi:10.1002/eji.1830251133. PMID 7489765.
  11. Vaughan JH, Nguyen MD, Valbracht JR, Patrick K, Rhodes GH (March 1995). "Epstein-Barr virus-induced autoimmune responses. II. Immunoglobulin G autoantibodies to mimicking and nonmimicking epitopes. Presence in autoimmune disease". J. Clin. Invest. 95 (3): 1316–27. doi:10.1172/JCI117782. PMC 441471. PMID 7533789.
  12. Winrow VR, Perry JD (June 1987). "Hyper-responsiveness to EBV in ankylosing spondylitis". Ann. Rheum. Dis. 46 (6): 493–4. PMC 1002175. PMID 2820321.
  13. Farkas B, Boldizsar F, Tarjanyi O, Laszlo A, Lin SM, Hutas G, Tryniszewska B, Mangold A, Nagyeri G, Rosenzweig HL, Finnegan A, Mikecz K, Glant TT (2009). "BALB/c mice genetically susceptible to proteoglycan-induced arthritis and spondylitis show colony-dependent differences in disease penetrance". Arthritis Res. Ther. 11 (1): R21. doi:10.1186/ar2613. PMC 2688253. PMID 19220900.
  14. Adarichev VA, Vegvari A, Szabo Z, Kis-Toth K, Mikecz K, Glant TT (October 2008). "Congenic strains displaying similar clinical phenotype of arthritis represent different immunologic models of inflammation". Genes Immun. 9 (7): 591–601. doi:10.1038/gene.2008.54. PMC 3951374. PMID 18650834.
  15. Calin A, Marder A, Becks E, Burns T (December 1983). "Genetic differences between B27 positive patients with ankylosing spondylitis and B27 positive healthy controls". Arthritis Rheum. 26 (12): 1460–4. PMID 6606431.
  16. van der Linden S, Valkenburg H, Cats A (November 1983). "The risk of developing ankylosing spondylitis in HLA-B27 positive individuals: a family and population study". Br. J. Rheumatol. 22 (4 Suppl 2): 18–9. PMID 6606472.
  17. Lochead JA, Chalmers IM, Marshall WH, Larsen B, Skanes VM, Payne RH, Barnard JM (August 1983). "HLA-B27 haplotypes in family studies of ankylosing spondylitis". Arthritis Rheum. 26 (8): 1011–6. PMID 6603847.
  18. van der Linden SM, Valkenburg HA, de Jongh BM, Cats A (March 1984). "The risk of developing ankylosing spondylitis in HLA-B27 positive individuals. A comparison of relatives of spondylitis patients with the general population". Arthritis Rheum. 27 (3): 241–9. PMID 6608352.
  19. LeClercq SA, Chaput L, Russell AS (August 1983). "Ankylosing spondylitis: a family study". J. Rheumatol. 10 (4): 629–32. PMID 6604814.
  20. Brown MA (2009). "Progress in spondylarthritis. Progress in studies of the genetics of ankylosing spondylitis". Arthritis Res. Ther. 11 (5): 254. doi:10.1186/ar2692. PMC 2787301. PMID 19886979.
  21. Li, Zhixiu; Brown, Matthew A (2017). "Progress of genome-wide association studies of ankylosing spondylitis". Clinical & Translational Immunology. 6 (12): e163. doi:10.1038/cti.2017.49. ISSN 2050-0068.
  22. Bal A, Unlu E, Bahar G, Aydog E, Eksioglu E, Yorgancioglu R (February 2007). "Comparison of serum IL-1 beta, sIL-2R, IL-6, and TNF-alpha levels with disease activity parameters in ankylosing spondylitis". Clin. Rheumatol. 26 (2): 211–5. doi:10.1007/s10067-006-0283-5. PMID 16583185.
  23. Bal A, Unlu E, Bahar G, Aydog E, Eksioglu E, Yorgancioglu R (February 2007). "Comparison of serum IL-1 beta, sIL-2R, IL-6, and TNF-alpha levels with disease activity parameters in ankylosing spondylitis". Clin. Rheumatol. 26 (2): 211–5. doi:10.1007/s10067-006-0283-5. PMID 16583185.
  24. Liu W, Wu YH, Zhang L, Liu XY, Xue B, Wang Y, Liu B, Jiang Q, Kwang HW, Wu DJ (2015). "Elevated serum levels of IL-6 and IL-17 may associate with the development of ankylosing spondylitis". Int J Clin Exp Med. 8 (10): 17362–76. PMC 4694228. PMID 26770328.
  25. Gratacós J, Collado A, Filella X, Sanmartí R, Cañete J, Llena J, Molina R, Ballesta A, Muñoz-Gómez J (October 1994). "Serum cytokines (IL-6, TNF-alpha, IL-1 beta and IFN-gamma) in ankylosing spondylitis: a close correlation between serum IL-6 and disease activity and severity". Br. J. Rheumatol. 33 (10): 927–31. PMID 7921752.

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