|IUPAC name||[(2S,3R,4R)-4-hydroxy-2-[(4-methoxyphenyl)methyl]pyrrolidin-3-yl] acetate|
|Except where noted otherwise, data are given for|
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references
Anisomycin, also known as Flagecidin (IUPAC name: 3,4-Pyrrolidinediol, 2-[(4-methoxyphenyl)methyl]-, 3-acetate, (2R,3S,4S)-) is an antibiotic produced by Streptomyces griseolus which inhibits protein synthesis. Partial inhibition of DNA synthesis occurs at anisomycin concentrations that effect 95% inhibition of protein synthesis . Anisomycin can activate stress-activated protein kinases, MAP kinase and other signal transduction pathways.
Anisomycin is inactive against bacteria.
Anisomycin is also mentioned as a potential psychiatric drug, as it may erase "short-range memory" .
Injection of anisomycin into the hippocampus has been proposed for selective removal of memories .
- Grollman AP (1967 Jul 10). "Inhibitors of protein biosynthesis. II. Mode of action of anisomycin". J. Biol. Chem. 242 (13): 3226–33. PMID 6027796. Free text (PDF - 990K)
- Barrientos RM, O'Reilly RC, Rudy JW (2002 Aug 21). "Memory for context is impaired by injecting anisomycin into dorsal hippocampus following context exploration". Behav. Brain Res. 134 (1-2): 299–306. PMID 12191817.
- Wang SH, Ostlund SB, Nader K, Balleine BW (2005). "Consolidation and reconsolidation of incentive learning in the amygdala". J. Neurosci. 25 (4): 830–5. PMID 15673662. Free text