Angiolymphoid hyperplasia with eosinophilia: Difference between revisions

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*Angiolymphoid hyperplasia with eosinophilia must be differentiated from other diseases that cause swelling of face and neck, such as:
*Angiolymphoid hyperplasia with eosinophilia must be differentiated from other diseases that cause swelling of face and neck, such as:
:*Kimura’s disease
:*Kimura’s disease
:*Acial granuloma
:*Insect bite reaction
:*Cutaneous lymphoma
:*Sarcoidosis


==Epidemiology and Demographics==
==Epidemiology and Demographics==

Revision as of 19:17, 9 May 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Kiran Singh, M.D. [2] Ammu Susheela, M.D. [3]

Synonyms and Keywords: Epithelioid hemangioma; Histiocytoid hemangioma; Inflammatory angiomatous nodule; Intravenous atypical vascular proliferation; Papular angioplasia; Inflammatory arteriovenous hemangioma; Pseudopyogenic granuloma; ALHE

Overview

Angiolymphoid hyperplasia with eosinophilia [1] is defined as red-brown, dome-shaped, dermal papule or nodule, present in the head or neck, specifically around the ears and on the scalp.[2]

Historical Perspective

  • [Disease name] was first discovered by [scientist name], a [nationality + occupation], in [year] during/following [event].
  • In [year], [gene] mutations were first identified in the pathogenesis of [disease name].
  • In [year], the first [discovery] was developed by [scientist] to treat/diagnose [disease name].

Classification

  • [Disease name] may be classified according to [classification method]

into [number] subtypes/groups:

  • [group1]
  • [group2]
  • [group3]
  • Other variants of [disease name] include [disease subtype 1],

[disease subtype 2], and [disease subtype 3].

Pathophysiology

  • The pathogenesis of angiolymphoid hyperplasia with eosinophilia is characterized by red to brown papules or nodules dislocated in the dermis or subcutaneous tissue.
  • Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare and idiopathic vascular disorder.
  • Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon benign lesion, primarily occurring in the head and neck.
  • The [gene name] gene/Mutation in [gene name] has been associated with the development of [disease name], involving the [molecular pathway] pathway.
  • On gross pathology, smooth-surface red to brown papules or nodules on the head, neck, trunk, extremities, genitalia, lips and oral mucosa; extracutaneous involvement are characteristic findings of angiolymphoid hyperplasia with eosinophilia.
  • On microscopic histopathological analysis, florid vascular proliferation with atypical endothelial cells surrounded by a lymphocytic and eosinophilic infiltrate are characteristic findings of angiolymphoid hyperplasia with eosinophilia.

Causes

  • Angiolymphoid hyperplasia with eosinophilia may be caused by either allergic reactions, traumas, or autoimmune disorders.

Differentiating Angiolymphoid hyperplasia with eosinophilia from other Diseases

  • Angiolymphoid hyperplasia with eosinophilia must be differentiated from other diseases that cause swelling of face and neck, such as:
  • Kimura’s disease
  • Acial granuloma
  • Insect bite reaction
  • Cutaneous lymphoma
  • Sarcoidosis

Epidemiology and Demographics

  • The prevalence of [disease name] is approximately [number or range] per 100,000 individuals worldwide.
  • In [year], the incidence of [disease name] was estimated to be [number or range] cases per 100,000 individuals in [location].

Age

  • Patients of all age groups may develop [disease name].
  • [Disease name] is more commonly observed among patients aged [age range] years old.
  • [Disease name] is more commonly observed among [elderly patients/young patients/children].

Gender

  • Females are more commonly affected with angiolymphoid hyperplasia with eosinophilia than males.

Race

  • Angiolymphoid hyperplasia with eosinophilia usually affects predominently individuals of the Asian race.

Risk Factors

  • Common risk factors in the development of angiolymphoid hyperplasia with eosinophilia are allergic reactions, traumas or autoimmune disorders.

Natural History, Complications and Prognosis

  • The majority of patients with [disease name] remain asymptomatic for

[duration/years].

  • Early clinical features include [manifestation 1], [manifestation 2],

and [manifestation 3].

  • If left untreated, [#%] of patients with [disease name] may progress

to develop [manifestation 1], [manifestation 2], and [manifestation 3].

  • Common complications of [disease name] include [complication 1],

[complication 2], and [complication 3].

  • Prognosis is generally [excellent/good/poor], and the [1/5/10year

mortality/survival rate] of patients with [disease name] is approximately [#%].

Diagnosis

Diagnostic Criteria

  • The diagnosis of [disease name] is made when at least [number] of the

following [number] diagnostic criteria are met:

  • [criterion 1]
  • [criterion 2]
  • [criterion 3]
  • [criterion 4]

Symptoms

  • [Disease name] is usually asymptomatic.
  • Symptoms of [disease name] may include the following:
  • [symptom 1]
  • [symptom 2]
  • [symptom 3]
  • [symptom 4]
  • [symptom 5]
  • [symptom 6]

Physical Examination

  • Patients with [disease name] usually appear [general appearance].
  • Physical examination may be remarkable for:
  • [finding 1]
  • [finding 2]
  • [finding 3]
  • [finding 4]
  • [finding 5]
  • [finding 6]

Laboratory Findings

  • There are no specific laboratory findings associated with [disease

name].

  • A [positive/negative] [test name] is diagnostic of [disease name].
  • An [elevated/reduced] concentration of

[serum/blood/urinary/CSF/other] [lab test] is diagnostic of [disease name].

  • Other laboratory findings consistent with the diagnosis of [disease

name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].

Imaging Findings

  • There are no [imaging study] findings associated with [disease name].
  • [Imaging study 1] is the imaging modality of choice for [disease

name].

  • On [imaging study 1], [disease name] is characterized by [finding 1],

[finding 2], and [finding 3].

  • [Imaging study 2] may demonstrate [finding 1], [finding 2], and

[finding 3].

Other Diagnostic Studies

  • [Disease name] may also be diagnosed using [diagnostic study name].
  • Findings on [diagnostic study name] include [finding 1], [finding 2],

and [finding 3].

Treatment

Medical Therapy

  • There is no treatment for [disease name]; the mainstay of therapy is

supportive care.

  • The mainstay of therapy for [disease name] is [medical therapy 1] and

[medical therapy 2].

  • [Medical therapy 1] acts by [mechanism of action1].
  • Response to [medical therapy 1] can be monitored with [test/physical

finding/imaging] every [frequency/duration].

Surgery

  • Surgery is the mainstay of therapy for angiolymphoid hyperplasia with eosinophilia.

Prevention

  • There are no primary preventive measures available for [disease

name].

  • Effective measures for the primary prevention of [disease name]

include [measure1], [measure2], and [measure3].

  • Once diagnosed and successfully treated, patients with [disease name]

are followedup every [duration]. Followup testing includes [test 1], [test 2], and [test 3].

Diagnosis

Ear

References

  1. Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0.
  2. James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.