Angiodysplasia risk factors: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
No edit summary
No edit summary
 
(12 intermediate revisions by 2 users not shown)
Line 1: Line 1:
__NOTOC__
__NOTOC__
{{Angiodysplasia}}
{{Angiodysplasia}}
{{CMG}} {{AE}} {{NKS}}
{{CMG}}; {{AE}} {{NKT}}
 
Please help WikiDoc by adding more content here.  It's easy!  Click  [[Help:How_to_Edit_a_Page|here]]  to learn about editing.


==Overview==
==Overview==
The most important [[risk factors]] for active bleeding from angiodysplasia include advanced age, cardiovascular [[comorbidities]], [[Von Willebrand disease|von Willebrand disease,]] [[End-stage renal disease|end-stage renal disease,]] and [[Antiplatelet drug|antiplatelet]] or [[Anticoagulants|anticoagulant]] use.


==Risk Factors ==
==Risk Factors==
[[Category:Gastroenterology]]
The most important [[risk factors]] for active bleeding from angiodysplasia include:<ref name="pmid27596107">{{cite journal| author=Nishimura N, Mizuno M, Shimodate Y, Doi A, Mouri H, Matsueda K | display-authors=etal| title=Risk factors for active bleeding from colonic angiodysplasia confirmed by colonoscopic observation. | journal=Int J Colorectal Dis | year= 2016 | volume= 31 | issue= 12 | pages= 1869-1873 | pmid=27596107 | doi=10.1007/s00384-016-2651-1 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27596107  }} </ref><ref name="pmid30348493">{{cite journal| author=Tsai YY, Chen BC, Chou YC, Lin JC, Lin HH, Huang HH | display-authors=etal| title=Clinical characteristics and risk factors of active bleeding in colonic angiodysplasia among the Taiwanese. | journal=J Formos Med Assoc | year= 2019 | volume= 118 | issue= 5 | pages= 876-882 | pmid=30348493 | doi=10.1016/j.jfma.2018.10.001 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30348493  }} </ref>
{{WS}}
{{WH}}


The  conditions most commonly associated with Angiodysplasia are:
*Advanced age (>60 years)
*Cardiovascular [[comorbidities]] like [[Hypertensive heart disease|hypertensive cardiovascular disease]], [[type 2 diabetes mellitus]], [[coronary artery disease]], [[valvular heart disease]], [[atrial fibrillation]]


=== 1.Aortic stenosis (AS) ===
*[[von Willebrand disease]]
- Heyde ''et al''  and then Schwartz ''et al'' were the first to report a possible association between AS and bleeding from AD in 1958. This was called ‘Heyde's Syndrome’.
*[[End-stage renal disease]]
*[[Antiplatelet drug|Antiplatelet]] or [[Anticoagulants|anticoagulant]] use
<br />


- A retrospective case–control study of 1443 patients found that the incidence of AS in patients with OGIB was much higher (25.5%) compared with controls (4.4).
==References==
{{Reflist|2}}


- Further support for this hypothesis comes from evidence of improvement or cessation of chronic GI bleeding in the vast majority of patients with AS after aortic valve replacement (AVR). This effect was sustained for up to 12 years after surgery in the largest case series of 91 patients.
[[Category:Gastroenterology]]
 
{{WS}}
- This observation has led to the hypothesis that abnormal von Willebrand factors (vWF) could provide the explanation to the increased risk of bleeding in patients with AS or aortic sclerosis and otherwise ‘silent’ AD.
[[Category:Up to Date]]
 
{{WH}}
=== Von Willebrand disease (vWD) ===
- Patients with certain subtypes of vWD are at an increased risk of GI bleeding from colonic AD. These patients have low levels of the high molecular weight (HMW) multimers of vWF, which is either hereditary (type 2a vWD) or acquired (AS).
 
=== Chronic renal failure (CRF) ===
- AD is more common in patients with CRF . Prevalence is related to the duration and severity of the kidney disease.
 
- AD accounts for 19–32% of Lower GI bleeding episodes in patients with CRF compared with 5–6% of episodes in the general population.
 
- Likewise, gastric and small bowel AD are reportedly the most common causes of upper GI bleeding and OGIB in these patients, respectively.
 
- Patients with CRF are at an increased risk of bleeding due to several mechanisms including uraemic platelet dysfunction75, 76 and use of anti‐coagulants.77 The causes of platelet dysfunction (aggregation and adhesion) are thought to be due to both intrinsic and extrinsic factors.76, 78 Intrinsic factors include reduced levels of agonists like adenosine diphosphate, serotonin, epinephrine, thrombin and collagen leading to impaired platelet function.79 It has also been noted that levels of platelet cyclic adenosine mono‐phosphate –which causes platelet dysfunction by mobilizing calcium – were high in patients with CRF. Extrinsic factors include release of toxins and increased nitric oxide, which inhibits platelet‐to‐platelet interaction and affects platelet to vessel wall interaction.
 
- AD is therefore an important cause of GI bleeding in patients with CRF. Other factors, which contribute to abnormalities in haemostasis, include reduced production of erythropoietin and effect of drugs.79

Latest revision as of 21:45, 25 April 2022

Angiodysplasia Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Angiodysplasia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

CT

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Angiodysplasia risk factors On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Angiodysplasia risk factors

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Angiodysplasia risk factors

CDC on Angiodysplasia risk factors

Angiodysplasia risk factors in the news

Blogs on Angiodysplasia risk factors

Directions to Hospitals Treating Angiodysplasia

Risk calculators and risk factors for Angiodysplasia risk factors

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nikita Singh, M.B.B.S.[2]

Overview

The most important risk factors for active bleeding from angiodysplasia include advanced age, cardiovascular comorbidities, von Willebrand disease, end-stage renal disease, and antiplatelet or anticoagulant use.

Risk Factors

The most important risk factors for active bleeding from angiodysplasia include:[1][2]


References

  1. ↑ Nishimura N, Mizuno M, Shimodate Y, Doi A, Mouri H, Matsueda K; et al. (2016). "Risk factors for active bleeding from colonic angiodysplasia confirmed by colonoscopic observation". Int J Colorectal Dis. 31 (12): 1869–1873. doi:10.1007/s00384-016-2651-1. PMID 27596107.
  2. ↑ Tsai YY, Chen BC, Chou YC, Lin JC, Lin HH, Huang HH; et al. (2019). "Clinical characteristics and risk factors of active bleeding in colonic angiodysplasia among the Taiwanese". J Formos Med Assoc. 118 (5): 876–882. doi:10.1016/j.jfma.2018.10.001. PMID 30348493.

Template:WS Template:WH

Retrieved from "https://www.wikidoc.org/index.php?title=Angiodysplasia_risk_factors&oldid=1722985"