Angiodysplasia overview

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Overview

In medicine (gastroenterology), angiodysplasia is a small, acquired vascular malformation of the gut. It is a common cause of otherwise unexplained gastrointestinal bleeding and anemia, especially after sixth decade of life. Lesions are often multiple, and frequently involve the cecum or ascending colon, although they can occur at other places. Treatment may be with endoscopic interventions, medication, or occasionally surgery.

Historical Perspective

The first case of angiodysplasia was described in a letter to the London Medical Gazette by Phillips as a vascular abnormality causing bleeding from the large bowel in 1839. However, the term "Angiodysplasia" was coined by Galdabini in 1974. Due to the unknown etiology of these lesions, multiple terms have been used, like arteriovenous malformation, telangiectasia, angioma, and hemangioma.[1]

Classification

One system of classification is based on location, size, and number of angiodysplasias. [2]

Classification of gastrointestinal angiodysplasia
Location Size Number of lesions
Gastric Minute (<2 mm in diameter) Unique (n = 1)
Duodenal Intermediate (2 to 5 mm) Multiple (n = 2 to 10)
Jejunal Large (>5 mm) Diffuse (n > 10)
Colonic
For example, "D-S2-N3" signifies multiple angiodysplasias of intermediate size in the duodenum.

Another system of classification uses endoscopic techniques to classify angiodysplasia depending on size, bleeding and surrounding venous dilatation. [3]

Type 1: Angioectasias:

Type 1 a - punctulate erythema (< 1 mm), with or without oozing

Type 1 b - patchy erythema (a few mm), with or without oozing

Type 2: Dieulafoy's lesions:

Type 2 a - punctulate lesions (< 1 mm), with pulsatile bleeding

Type 2b - pulsatile red protrusion, without surrounding venous dilatation

Type 3 - pulsatile red protrusion, with surrounding venous dilatation

Type 4 - other lesions not classified into any of the above categories.

Pathophysiology

Exact etiology of angiodysplasia is unclear. Various theories appear in the literature. According to one theory, ageing and intermittent, low-grade obstruction of submucosal veins in the muscularis propria layer leads to the formation of small arterio-venous collaterals. Another theory states that due to chronic hypoxia in conditions like, aortic stenosis, von Willebrand disease (VWD) and cardiac diseases, angiogenic factors like vascular endothelial growth factor (VEGF) and basic fibroblast growth factor increase which contribute to the development of angiodysplasia.

Causes

Differentiating Angiodysplasia overview from Other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications, and Prognosis

Natural History

Complications

Prognosis

Diagnosis

Diagnostic Criteria

History and Symptoms

Physical Examination

Laboratory Findings

Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

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Prevention

References

  1. Athanasoulis, C. A.; Galdabini, J. J.; Waltman, A. C.; Novelline, R. A.; Greenfield, A. J.; Ezpeleta, M. L. (1978). "Angiodysplasia of the colon: A cause of rectal bleeding". Cardiovascular Radiology. 1 (1): 3–13. doi:10.1007/BF02551967. ISSN 0342-7196.
  2. Schmit A, Van Gossum A (1998). "Proposal for an endoscopic classification of digestive angiodysplasias for therapeutic trials. The European Club of Enteroscopy". Gastrointest Endosc. 48 (6): 659. doi:10.1016/s0016-5107(98)70080-x. PMID 9852467.
  3. Yano T, Yamamoto H, Sunada K, Miyata T, Iwamoto M, Hayashi Y; et al. (2008). "Endoscopic classification of vascular lesions of the small intestine (with videos)". Gastrointest Endosc. 67 (1): 169–72. doi:10.1016/j.gie.2007.08.005. PMID 18155439.

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