Angiodysplasia medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Nikita Singh, M.D.[2]

Overview

Treatment is not required for incidentally found, asymptomatic, non-bleeding lesions. However, it is considered for non-bleeding angiodysplasia with symptoms of occult or overt GI bleed. The invasiveness of therapy depends on clinical severity of anemia, hemodynamic stability and recurrence of symptoms. Although endoscopic techniques are the first choice, hormonal therapy, thalidomide and octreotide are the pharmacological options that have been tried for patients with significant co-morbidities who cannot undergo invasive procedures.

Medical Therapy

Pharmacological options like hormonal therapy, thalidomide and octreotide have been tried in patients with significant co-morbidities who cannot undergo invasive procedures.

Studies have shown hormonal therapy with ethinylestradiol and norethisterone vs placebo have no difference in outcomes. However, a few case series have shown positive results regarding the efficacy of hormonal therapy in chronic renal failure patients.

References

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