Angiodysplasia future or investigational therapies

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In a study, significantly lower levels of Angiopoietin-1 (Ang-1) and TNF-α were found in patients with small bowel angiodysplasia as compared to the control group.[1] Despite similar progress in some other studies, the use of chemical markers of angiogenesis as diagnostic tool for angiodysplasia is still at an early stage and would require further research into this area.

Further insight into the pathogenesis of angiodysplasia is required for better diagnostic and therapeutic options of this condition.[2]

References

  1. Holleran G, Hussey M, Smith S, McNamara D (2017). "Assessment of serum angiogenic factors as a diagnostic aid for small bowel angiodysplasia in patients with obscure gastrointestinal bleeding and anaemia". World J Gastrointest Pathophysiol. 8 (3): 127–132. doi:10.4291/wjgp.v8.i3.127. PMC 5561433. PMID 28868182.
  2. García-Compeán D, Del Cueto-Aguilera ÁN, Jiménez-Rodríguez AR, González-González JA, Maldonado-Garza HJ (2019). "Diagnostic and therapeutic challenges of gastrointestinal angiodysplasias: A critical review and view points". World J Gastroenterol. 25 (21): 2549–2564. doi:10.3748/wjg.v25.i21.2549. PMC 6558444 Check |pmc= value (help). PMID 31210709.

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