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==Overview==
==Overview==

Revision as of 00:10, 7 July 2017

Androgen insensitivity syndrome Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aravind Reddy Kothagadi M.B.B.S[2]

Overview

Androgen insensitivity syndrome (AIS) results from androgen receptor dysfunction and is a common cause of disorder of sex development. The AIS phenotype largely depends on the degree of residual androgen receptor (AR) activity. [1]

Medical Therapy

  • A multidisciplinary approach is recommended for clinical management from infancy through to adulthood.[1]
  • Hormone replacement therapy is needed following gonadectomy.
  • Patients who choose to retain the gonads are at risk of developing germ cell tumors for which sensitive circulating tumor markers may soon become available.

References

  1. 1.0 1.1 Mongan NP, Tadokoro-Cuccaro R, Bunch T, Hughes IA (2015). "Androgen insensitivity syndrome". Best Pract Res Clin Endocrinol Metab. 29 (4): 569–80. doi:10.1016/j.beem.2015.04.005. PMID 26303084.

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