Anaplastic large cell lymphoma differential diagnosis: Difference between revisions

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__NOTOC__
__NOTOC__
{{Anaplastic large cell lymphoma}}
[[Image:Home_logo1.png|right|250px|link=http://www.wikidoc.org/index.php/Anaplastic_large_cell_lymphoma]]
{{CMG}}; {{AE}} {{AS}}
{{CMG}}; {{AE}} {{AS}}
==Overview==
==Overview==
Anaplastic large cell lymphoma must be differentiated from other diseases such as [[metastatic]] [[carcinoma]], [[B cell lymphoma]], primary cutaneous T-cell lymphoma, rhabdomyosarcoma, peripheral T-cell lymphoma-not otherwise specified, classical Hodgkin's lymphoma, and diffuse large B cell lymphoma.
==Differential diagnosis==
* As the appearance of the hallmark cells, pattern of growth (nesting within lymph nodes) and positivity for EMA may mimic [[metastatic]] [[carcinoma]], it is important to include markers for [[cytokeratin]] in any diagnostic panel (these will be negative in the case of anaplastic lymphoma).
* Other mimics include CD30 positive B-cell lymphomas with anaplastic cells (including Hodgkin lymphomas).  These are identified by their positivity for markers of B-cell lineage and frequent presence of markers of EBV.
* Primary cutaneous T-cell lymphomas may also be positive for CD30; these are excluded by their anatomic distribution.
* ALK positivity may also be seen in some large cell B-cell lymphomas and occasionally in [[rhabdomyosarcoma]]s.
* Peripheral T-cell lymphoma-not otherwise specified (PTCL-NOS)<ref name="pmid22789917">{{cite journal| author=Ferreri AJ, Govi S, Pileri SA, Savage KJ| title=Anaplastic large cell lymphoma, ALK-negative. | journal=Crit Rev Oncol Hematol | year= 2013 | volume= 85 | issue= 2 | pages= 206-15 | pmid=22789917 | doi=10.1016/j.critrevonc.2012.06.004 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22789917  }} </ref><ref name="ALK+/ALK-">{{cite web|url=http://www.bloodjournal.org/content/111/12/5496?sso-checked=true|title=ALK- anaplastic large-cell lymphoma is clinically and immunophenotypically different from both ALK+ ALCL and peripheral T-cell lymphoma, not otherwise specified: report from the International Peripheral T-Cell Lymphoma Project}}</ref>
*Classical [[Hodgkin's lymphoma]]<ref name="pmid22789917">{{cite journal| author=Ferreri AJ, Govi S, Pileri SA, Savage KJ| title=Anaplastic large cell lymphoma, ALK-negative. | journal=Crit Rev Oncol Hematol | year= 2013 | volume= 85 | issue= 2 | pages= 206-15 | pmid=22789917 | doi=10.1016/j.critrevonc.2012.06.004 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22789917  }} </ref>
*Diffuse large B-cell lymphoma


{| style="border: 0px; font-size: 90%; margin: 3px; width: 1000px" align=center
==Differential Diagnosis==
|valign=top|
|+
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Differential Diagnosis}}
! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|Similar Features}}
! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|Differentiating Features}}
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;"|[[Metastatic]] [[carcinoma]]
| style="padding: 5px 5px; background: #F5F5F5;"|
* On  diagnostic test, [[Metastatic]] [[carcinoma]] demonstrates nesting within lymph nodes, positivity for EMA also observed in anaplastic large cell lymphoma.
| style="padding: 5px 5px; background: #F5F5F5;"|
* On  diagnostic test, [[Metastatic]] [[carcinoma]] demonstrates positivity for markers [[cytokeratin]] that distinguish it from  anaplastic large cell lymphoma.
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;"| [[B-cell lymphoma]]
| style="padding: 5px 5px; background: #F5F5F5;"|
* On diagnostic test, B-cell lymphoma demonstrates [[CD30]], anaplastic cells, [[ALK]] positivity also observed in anaplastic large cell lymphoma.
| style="padding: 5px 5px; background: #F5F5F5;"|
* On  diagnostic test, B-cell lymphoma demonstrates positivity for markers of B-cell lineage and frequent presence of markers of EBV that distinguish it from anaplastic large cell lymphoma.
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;"| Primary cutaneous [[T-cell lymphoma]]
| style="padding: 5px 5px; background: #F5F5F5;"|
* On diagnostic test, Primary cutaneous T-cell lymphoma demonstrates  [[CD30]] also observed  in anaplastic large cell lymphoma.
| style="padding: 5px 5px; background: #F5F5F5;"|
* On physical exam, Primary cutaneous T-cell lymphoma demonstrates  different anatomic distribution that distinguish it from anaplastic large cell lymphoma.
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;"| [[Rhabdomyosarcoma]]
| style="padding: 5px 5px; background: #F5F5F5;"|
* On diagnostic test, [[Rhabdomyosarcoma]] demonstrates [[ALK]] positivity also observed in anaplastic large cell lymphoma.
| style="padding: 5px 5px; background: #F5F5F5;"|
* On [physical exam; history; diagnostic test; imaging], [Differential 1] {has; demonstrates} [feature 1], [feature 2], [feature 3] that distinguish it from [disease name].
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;"|Differential 5
| style="padding: 5px 5px; background: #F5F5F5;"|
* On [physical exam; history; diagnostic test; imaging], [Differential 1] {has; demonstrates} [feature 1], [feature 2], [feature 3] also observed in [disease name].
| style="padding: 5px 5px; background: #F5F5F5;"|
* On [physical exam; history; diagnostic test; imaging], [Differential 1] {has; demonstrates} [feature 1], [feature 2], [feature 3] that distinguish it from [disease name].
|}


==References==
==References==
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[[Category:Hematology]]
[[Category:Hematology]]
[[Category:Types of cancer]]
[[Category:Types of cancer]]
[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Hematology]]
[[Category:Immunology]]

Latest revision as of 20:31, 28 February 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

Differential Diagnosis

References

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