Analgesic nephropathy natural history, complications and prognosis: Difference between revisions
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{{Analgesic nephropathy}} | {{Analgesic nephropathy}} | ||
{{CMG}} | {{CMG}} {{AE}} {{SHA}} | ||
==Overview== | ==Overview== | ||
The prognosis of analgesic nephropathy depends on the scarring and damage to the renal tissue. Most patients in early stages recover to normal [[renal function]] after stopping the [[analgesic]] drug, however some may progress to [[End stage renal disease|end stage renal disease (ESRD)]]. Complications of analgesic nephropathy include: [[Urinary tract infection|urinary tract infections]], varying degrees of [[Renal insufficiency|renal failure]] and [[End stage renal disease|End stage renal disease (ESRD)]]. | |||
==Natural History== | ==Natural History== | ||
* [[Renal function]] in most patients recovers to normal level after stopping the usage of [[analgesic]] drug if it is in the early stages of the disease.<ref name="pmid31082145" /> | |||
* Depending on the scarring and damage to the renal tissue, some patients may progress to [[End stage renal disease|end stage renal disease (ESRD)]], even after stopping the usage of [[analgesic]] drug.<ref name="pmid31082145" /> | |||
==Complications== | ==Complications== | ||
Complications of analgesic nephropathy | Complications associated with analgesic nephropathy include:<ref name="pmid7002190">{{cite journal| author=Nanra RS| title=Clinical and pathological aspects of analgesic nephropathy. | journal=Br J Clin Pharmacol | year= 1980 | volume= 10 Suppl 2 | issue= | pages= 359S-368S | pmid=7002190 | doi=10.1111/j.1365-2125.1980.tb01824.x | pmc=1430193 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7002190 }} </ref><ref name="pmid362034">{{cite journal| author=Nanra RS, Stuart-Taylor J, de Leon AH, White KH| title=Analgesic nephropathy: etiology, clinical syndrome, and clinicopathologic correlations in Australia. | journal=Kidney Int | year= 1978 | volume= 13 | issue= 1 | pages= 79-92 | pmid=362034 | doi=10.1038/ki.1978.11 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=362034 }} </ref> | ||
* [[Urinary tract infection|Urinary tract infections]] | |||
* Varying degrees of [[Renal insufficiency|renal failure]] | |||
* [[End stage renal disease|End stage renal disease (ESRD)]]<ref name="pmid31082145">{{cite journal| author=| title=StatPearls | journal= | year= 2020 | volume= | issue= | pages= | pmid=31082145 | doi= | pmc= | url= }} </ref> | |||
* [[Transitional cell carcinoma|Transitional cell tumours]] of the [[urothelium]] (in abuse of [[Analgesic|analgesics]] containing [[phenacetin]]) | |||
==Prognosis== | ==Prognosis== | ||
The prognosis of analgesic nephropathy depends on the scarring and damage to the renal tissue. Most patients in early stages recover to normal [[renal function]] after stopping the [[analgesic]] drug, however some may progress to [[End stage renal disease|end stage renal disease (ESRD)]].<ref name="pmid31082145" /> | |||
Some factors that contribute to poor outcome include:<ref name="pmid7002190" /> | |||
* [[Malignant hypertension]] | |||
* Persistent [[proteinuria]] | |||
* Initial renal size and [[Glomerular filtration rate|glomerular filtration rate (GFR)]] | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Latest revision as of 06:21, 8 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shakiba Hassanzadeh, MD[2]
Overview
The prognosis of analgesic nephropathy depends on the scarring and damage to the renal tissue. Most patients in early stages recover to normal renal function after stopping the analgesic drug, however some may progress to end stage renal disease (ESRD). Complications of analgesic nephropathy include: urinary tract infections, varying degrees of renal failure and End stage renal disease (ESRD).
Natural History
- Renal function in most patients recovers to normal level after stopping the usage of analgesic drug if it is in the early stages of the disease.[1]
- Depending on the scarring and damage to the renal tissue, some patients may progress to end stage renal disease (ESRD), even after stopping the usage of analgesic drug.[1]
Complications
Complications associated with analgesic nephropathy include:[2][3]
- Urinary tract infections
- Varying degrees of renal failure
- End stage renal disease (ESRD)[1]
- Transitional cell tumours of the urothelium (in abuse of analgesics containing phenacetin)
Prognosis
The prognosis of analgesic nephropathy depends on the scarring and damage to the renal tissue. Most patients in early stages recover to normal renal function after stopping the analgesic drug, however some may progress to end stage renal disease (ESRD).[1]
Some factors that contribute to poor outcome include:[2]
- Malignant hypertension
- Persistent proteinuria
- Initial renal size and glomerular filtration rate (GFR)
References
- ↑ 1.0 1.1 1.2 1.3 "StatPearls". 2020. PMID 31082145.
- ↑ 2.0 2.1 Nanra RS (1980). "Clinical and pathological aspects of analgesic nephropathy". Br J Clin Pharmacol. 10 Suppl 2: 359S–368S. doi:10.1111/j.1365-2125.1980.tb01824.x. PMC 1430193. PMID 7002190.
- ↑ Nanra RS, Stuart-Taylor J, de Leon AH, White KH (1978). "Analgesic nephropathy: etiology, clinical syndrome, and clinicopathologic correlations in Australia". Kidney Int. 13 (1): 79–92. doi:10.1038/ki.1978.11. PMID 362034.