Alzheimer's disease pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Alzheimer's disease Microchapters
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Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Alzheimer's disease from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic study of choice
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
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Other Imaging Findings
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Treatment
Medical Therapy
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Primary Prevention
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Cost-Effectiveness of Therapy
Future or Investigational Therapies
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Overview

Pathogenesis

MRI images of a normal aged brain (right) and an Alzheimer's patient's brain (left). In the Alzheimer brain, atrophy is clearly seen.

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  Microscopy image of a neurofibrillary tangle, conformed by hyperphosphorylated tau protein.

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  In Alzheimer's disease, changes in tau protein lead to the disintegration of microtubules in brain cells.

Associated Conditions

• Cerebral amyloid angiopathy

References