Alprenolol

Alprenolol
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral
ATC code	C07AA01 (WHO) ;
Pharmacokinetic data
Protein binding	80% - 90%
Elimination half-life	2-3 hours → 4-OH-alprenolol
Identifiers
	IUPAC name (RS)-1-(2-allylphenoxy)-3-(isopropylamino)propan-2-ol;
CAS Number	13655-52-2 ;
PubChem CID	2119;
IUPHAR/BPS	563;
DrugBank	DB00866 ;
ChemSpider	2035 ;
UNII	877K5MQ27W;
KEGG	D07156 ;
ChEBI	CHEBI:51211 ;
ChEMBL	ChEMBL266195 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C15H23NO2
Molar mass	249.34 g/mol
3D model (JSmol)	Interactive image;
	SMILES O(c1ccccc1C\C=C)CC(O)CNC(C)C;
	InChI InChI=1S/C15H23NO2/c1-4-7-13-8-5-6-9-15(13)18-11-14(17)10-16-12(2)3/h4-6,8-9,12,14,16-17H,1,7,10-11H2,2-3H3 ; Key:PAZJSJFMUHDSTF-UHFFFAOYSA-N ;
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sheng Shi, M.D. [2]

Synonyms / Brand Names: Atenenol (Tsuruhara Seiyaku, Japan); Elp (Shyh Dar, Taiwan); Skajilol (Kotobuki Seiyaku, Japan)

Overview

Alprenolol, or alfeprol, alpheprol, and alprenololum (Gubernal, Regletin, Yobir, Apllobal, Aptine, Aptol Duriles), is a non-selective beta blocker as well as 5-HT_1A receptor antagonist, used in the treatment of angina pectoris.^[1] It is no longer marketed by AstraZeneca, but may still be available from other pharmaceutical companies or generically.

References

↑ Hickie JB (August 1970). "Alprenolol ("aptin") in angina pectoris. A double-blind multicentre trial". Med. J. Aust. 2 (6): 268–72. PMID 4393977.

[pmid4393977-1] Hickie JB (August 1970). "Alprenolol ("aptin") in angina pectoris. A double-blind multicentre trial". Med. J. Aust. 2 (6): 268–72. PMID 4393977.

[1]

v t e Beta blockers (C07)
Non-selective β antagonists	Metipranolol • Nadolol • Oxprenolol • Penbutolol • Pindolol • Propranolol • Tertatolol • Timolol • Sotalol
β₁ antagonists (cardioselective)	Atenolol • Acebutolol • Celiprolol • Betaxolol • Bisoprolol • Esmolol • Metoprolol • Nebivolol
Mixed α₁/β antagonists	Carvedilol • Labetalol

Clinical data

AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
ATC code	C07AA01 (WHO)
Pharmacokinetic data
Protein binding	80% - 90%
Elimination half-life	2-3 hours → 4-OH-alprenolol
Identifiers
IUPAC name (RS)-1-(2-allylphenoxy)-3-(isopropylamino)propan-2-ol
CAS Number	13655-52-2^Y
PubChem CID	2119
IUPHAR/BPS	563
DrugBank	DB00866^Y
ChemSpider	2035^Y
UNII	877K5MQ27W
KEGG	D07156^Y
ChEBI	CHEBI:51211^Y
ChEMBL	ChEMBL266195^Y
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₁₅H₂₃NO₂
Molar mass	249.34 g/mol
3D model (JSmol)	Interactive image
SMILES O(c1ccccc1C\C=C)CC(O)CNC(C)C
InChI InChI=1S/C15H23NO2/c1-4-7-13-8-5-6-9-15(13)18-11-14(17)10-16-12(2)3/h4-6,8-9,12,14,16-17H,1,7,10-11H2,2-3H3^Y Key:PAZJSJFMUHDSTF-UHFFFAOYSA-N^Y
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Alprenolol

Overview

References

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