Alpha 2-antiplasmin

Identifiers
Symbol	SERPINF2
Alt. symbols	PLI
Entrez	5345
HUGO	9075
OMIM	262850
RefSeq	NM_000934
UniProt	P08697
Other data
Locus	Chr. 17 pter-p12

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Alpha 2-antiplasmin (or α₂-antiplasmin or plasmin inhibitor) is a serine protease inhibitor (serpin) responsible for inactivating plasmin, an important enzyme that participates in fibrinolysis and degradation of various other proteins.

Fibrinolysis (simplified). Blue arrows denote stimulation, and red arrows inhibition.

Role in disease

Very few cases (<20) of A2AP deficiency have been described. As plasmin degrades blood clots, impaired inhibition of plasmin leads to a bleeding tendency, which was severe in the cases reported.

External links

• alpha-2+Antiplasmin at the US National Library of Medicine Medical Subject Headings (MeSH)

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