Alpha-2C adrenergic receptor

Adrenergic, alpha-2C-, receptor
File:PBB Protein ADRA2C image.jpg PDB rendering based on 1hll.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1hll​, 1ho9​, 1hod​, 1hof​
Identifiers
Symbols	ADRA2C ; ADRA2L2; ADRA2RL2; ADRARL2; ALPHA2CAR
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20170
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

The alpha-2C adrenergic receptor (α_2C adrenoreceptor), also known as ADRA2C, is an alpha-2 adrenergic receptor, and also denotes the human gene encoding it.

Receptor

Alpha-2-adrenergic receptors include 3 highly homologous subtypes: alpha_2A, alpha_2B, and alpha_2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha_2A and alpha_2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha_2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha_2C subtype modulated neurotransmission at lower levels of nerve activity.

Gene

This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences.

See also

• Adrenergic receptor

Further reading

• Coupry I, Duzic E, Lanier SM (1992). "Factors determining the specificity of signal transduction by guanine nucleotide-binding protein-coupled receptors. II. Preferential coupling of the alpha 2C-adrenergic receptor to the guanine nucleotide-binding protein, Go". J. Biol. Chem. 267 (14): 9852–7. PMID 1349607.CS1 maint: Multiple names: authors list (link)
• Chhajlani V, Rangel N, Uhlén S, Wikberg JE (1991). "Identification of an additional gene belonging to the alpha 2 adrenergic receptor family in the human genome by PCR". FEBS Lett. 280 (2): 241–4. PMID 1849485.CS1 maint: Multiple names: authors list (link)
• Regan JW, Kobilka TS, Yang-Feng TL; et al. (1988). "Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype". Proc. Natl. Acad. Sci. U.S.A. 85 (17): 6301–5. PMID 2842764.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Eason MG, Liggett SB (1993). "Human alpha 2-adrenergic receptor subtype distribution: widespread and subtype-selective expression of alpha 2C10, alpha 2C4, and alpha 2C2 mRNA in multiple tissues". Mol. Pharmacol. 44 (1): 70–5. PMID 7688069.
• Riess O, Thies U, Siedlaczck I; et al. (1994). "Precise mapping of the brain alpha 2-adrenergic receptor gene within chromosome 4p16". Genomics. 19 (2): 298–302. doi:10.1006/geno.1994.1061. PMID 8188260.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Klein U, Ramirez MT, Kobilka BK, von Zastrow M (1997). "A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2B". J. Biol. Chem. 272 (31): 19099–102. PMID 9235896.CS1 maint: Multiple names: authors list (link)
• Schaak S, Devedjian JC, Cayla C; et al. (1998). "Molecular cloning, sequencing and functional study of the promoter region of the human alpha2C4-adrenergic receptor gene". Biochem. J. 328 ( Pt 2): 431–8. PMID 9371698.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• DeGraff JL, Gagnon AW, Benovic JL, Orsini MJ (1999). "Role of arrestins in endocytosis and signaling of alpha2-adrenergic receptor subtypes". J. Biol. Chem. 274 (16): 11253–9. PMID 10196213.CS1 maint: Multiple names: authors list (link)
• Prezeau L, Richman JG, Edwards SW, Limbird LE (1999). "The zeta isoform of 14-3-3 proteins interacts with the third intracellular loop of different alpha2-adrenergic receptor subtypes". J. Biol. Chem. 274 (19): 13462–9. PMID 10224112.CS1 maint: Multiple names: authors list (link)
• Hein L, Altman JD, Kobilka BK (2000). "Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission". Nature. 402 (6758): 181–4. doi:10.1038/46040. PMID 10647009.CS1 maint: Multiple names: authors list (link)
• Small KM, Forbes SL, Rahman FF; et al. (2000). "A four amino acid deletion polymorphism in the third intracellular loop of the human alpha 2C-adrenergic receptor confers impaired coupling to multiple effectors". J. Biol. Chem. 275 (30): 23059–64. doi:10.1074/jbc. M000796200 . PMID 10801795.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Comings DE, Gade-Andavolu R, Gonzalez N; et al. (2001). "Multivariate analysis of associations of 42 genes in ADHD, ODD and conduct disorder". Clin. Genet. 58 (1): 31–40. PMID 10945659.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Small KM, Wagoner LE, Levin AM; et al. (2002). "Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure". N. Engl. J. Med. 347 (15): 1135–42. doi:10.1056/NEJMoa020803. PMID 12374873.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chotani MA, Mitra S, Su BY; et al. (2004). "Regulation of alpha(2)-adrenoceptors in human vascular smooth muscle cells". Am. J. Physiol. Heart Circ. Physiol. 286 (1): H59–67. doi:10.1152/ajpheart.00268.2003. PMID 12946937.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Small KM, Mialet-Perez J, Seman CA; et al. (2004). "Polymorphisms of cardiac presynaptic alpha2C adrenergic receptors: Diverse intragenic variability with haplotype-specific functional effects". Proc. Natl. Acad. Sci. U.S.A. 101 (35): 13020–5. doi:10.1073/pnas.0405074101. PMID 15319474.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chotani MA, Mitra S, Eid AH; et al. (2005). "Distinct cAMP signaling pathways differentially regulate alpha2C-adrenoceptor expression: role in serum induction in human arteriolar smooth muscle cells". Am. J. Physiol. Heart Circ. Physiol. 288 (1): H69–76. doi:10.1152/ajpheart.01223.2003. PMID 15345481.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Belfer I, Buzas B, Hipp H; et al. (2005). "Haplotype-based analysis of alpha 2A, 2B, and 2C adrenergic receptor genes captures information on common functional loci at each gene". J. Hum. Genet. 50 (1): 12–20. doi:10.1007/s10038-004-0211-y. PMID 15592690.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Neumeister A, Charney DS, Belfer I; et al. (2005). "Sympathoneural and adrenomedullary functional effects of alpha2C-adrenoreceptor gene polymorphism in healthy humans". Pharmacogenet. Genomics. 15 (3): 143–9. PMID 15861038.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Neumeister A, Drevets WC, Belfer I; et al. (2006). "Effects of an alpha 2C-adrenoreceptor gene polymorphism on neural responses to facial expressions in depression". Neuropsychopharmacology. 31 (8): 1750–6. doi:10.1038/sj.npp.1301010. PMID 16407897.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Park JS, Zhang SY, Jo SH; et al. (2006). "Common adrenergic receptor polymorphisms as novel risk factors for vasospastic angina". Am. Heart J. 151 (4): 864–9. doi:10.1016/j.ahj.2005.06.009. PMID 16569551.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)