Alopecia pathophysiology: Difference between revisions
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{{CMG}}; {{AE}} {{KS}} [[Ogechukwu Hannah Nnabude, MD]] | |||
==Overview== | |||
The pathophysiology of alopecia is dependent on the type of alopecia. | |||
==Pathophysiology== | |||
In the case of alopecia areata, the exact pathophysiology is currently unknown, however, the prevailing hypothesis is that it is as a result of T-cell–mediated autoimmunity. In androgenetic alopecia, both hormonal and genetic factors play a role in the pathogenesis. In telogen effluvium, the hair loss may influenced by hormones or stress, or other unknown factors. <ref name="pmid30511001">Yu L, Lu Z (2018) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=30511001 Linear alopecia areata.] ''JAAD Case Rep'' 4 (10):1072-1073. [http://dx.doi.org/10.1016/j.jdcr.2018.08.015 DOI:10.1016/j.jdcr.2018.08.015] PMID: [https://pubmed.gov/30511001 30511001]</ref> The dermatophyte infection is responsible for hair loss in tinea capitis. In anagen effluvium, the shedding of hair is under the effect of chemotherapeutic agents. In alopecia mucinosa, the infiltration of the scalp with abnormal lymphocytes is the cause. <ref name="pmid30501016">{{cite journal| author=Davey L, Clarke V, Jenkinson E| title=Living with alopecia areata: an online qualitative survey study. | journal=Br J Dermatol | year= 2019 | volume= 180 | issue= 6 | pages= 1377-1389 | pmid=30501016 | doi=10.1111/bjd.17463 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30501016 }} </ref> | |||
==Histopathology== | |||
In androgenetic alopecia, there are miniaturized hair follicles with an increase in the telogen-to-anagen ratio without inflammatory reaction. In anagen effluvium, there is a decrease in anagen hair without any inflammatory response. Finally, in alopecia mucinosa, there is an infiltrate of the epidermis, dermis, and peribulbar lymphocytic infiltrate mainly anaplastic cells. In patients with alopecia areata, there is a peribulbar lymphocytic infiltrate with a decrease in the ratio of anagen to telogen hair. Telogen effluvium is characterized by an increase in the number of catagen hair. In tinea capitis, there is evidence of fungal infection as under a microscope along with a neutrophilic infiltrate. | |||
==References== | ==References== | ||
Revision as of 02:33, 12 December 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kiran Singh, M.D. [2] Ogechukwu Hannah Nnabude, MD
Overview
The pathophysiology of alopecia is dependent on the type of alopecia.
Pathophysiology
In the case of alopecia areata, the exact pathophysiology is currently unknown, however, the prevailing hypothesis is that it is as a result of T-cell–mediated autoimmunity. In androgenetic alopecia, both hormonal and genetic factors play a role in the pathogenesis. In telogen effluvium, the hair loss may influenced by hormones or stress, or other unknown factors. [1] The dermatophyte infection is responsible for hair loss in tinea capitis. In anagen effluvium, the shedding of hair is under the effect of chemotherapeutic agents. In alopecia mucinosa, the infiltration of the scalp with abnormal lymphocytes is the cause. [2]
Histopathology
In androgenetic alopecia, there are miniaturized hair follicles with an increase in the telogen-to-anagen ratio without inflammatory reaction. In anagen effluvium, there is a decrease in anagen hair without any inflammatory response. Finally, in alopecia mucinosa, there is an infiltrate of the epidermis, dermis, and peribulbar lymphocytic infiltrate mainly anaplastic cells. In patients with alopecia areata, there is a peribulbar lymphocytic infiltrate with a decrease in the ratio of anagen to telogen hair. Telogen effluvium is characterized by an increase in the number of catagen hair. In tinea capitis, there is evidence of fungal infection as under a microscope along with a neutrophilic infiltrate.
References
- ↑ Yu L, Lu Z (2018) Linear alopecia areata. JAAD Case Rep 4 (10):1072-1073. DOI:10.1016/j.jdcr.2018.08.015 PMID: 30511001
- ↑ Davey L, Clarke V, Jenkinson E (2019). "Living with alopecia areata: an online qualitative survey study". Br J Dermatol. 180 (6): 1377–1389. doi:10.1111/bjd.17463. PMID 30501016.