Alopecia diagnostic study of choice: Difference between revisions
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==Overview== | ==Overview== | ||
The diagnostic test of choice varies with the cause of alopecia. Biopsy, laboratory tests, trichoscopy, and hair pull test are some of the techniques used in diagnosis. [[Chest X-ray]] and [[MRI]] can be used in [[mycosis fungoides]] staging and is useful for alopecia mucinosa while microscopic testing and Wood's lamp is useful for the diagnosis of fungal infection <ref name="pmid22972730">{{cite journal| author=Ponka D, Baddar F| title=Wood lamp examination. | journal=Can Fam Physician | year= 2012 | volume= 58 | issue= 9 | pages= 976 | pmid=22972730 | doi= | pmc=3440273 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22972730 }} </ref>. | The diagnostic test of choice varies with the cause of [[alopecia]]. [[Biopsy]], [[laboratory tests]], [[trichoscopy]], and [[hair pull test]] are some of the techniques used in diagnosis. [[Chest X-ray]] and [[MRI]] can be used in [[mycosis fungoides]] [[staging]] and is useful for [[alopecia mucinosa]] while microscopic testing and [[Wood's lamp]] is useful for the diagnosis of [[fungal infection]] <ref name="pmid22972730">{{cite journal| author=Ponka D, Baddar F| title=Wood lamp examination. | journal=Can Fam Physician | year= 2012 | volume= 58 | issue= 9 | pages= 976 | pmid=22972730 | doi= | pmc=3440273 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22972730 }} </ref>. | ||
==Diagnostic Test of Choice== | ==Diagnostic Test of Choice== | ||
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'''Hair Pull Test''' | '''Hair Pull Test''' | ||
Test for excessive shedding, it is not diagnostic of a particular hair loss but indicates active hair loss is occurring. Hair should not be washed 24-48 | Test for excessive shedding, it is not diagnostic of a particular hair loss but indicates active hair loss is occurring. Hair should not be washed 24-48 hours prior to a hair pull test. It is performed by gently grasping 40-60 hairs and gently pull upward from different parts of the scalp. | ||
A positive test is when three to six or more strands are pulled out. | A positive test is when three to six or more strands are pulled out. | ||
The pull test is positive in: | The pull test is positive in: | ||
* androgenetic alopecia | * [[androgenetic alopecia]] | ||
* alopecia areata and scarring alopecia | * [[alopecia areata]] and [[scarring alopecia]] | ||
* telogen effluvium | * [[telogen effluvium]] | ||
* anagen effluvium | * [[anagen effluvium]] | ||
* loose anagen syndrome | * [[loose anagen syndrome]] | ||
Evaluation of the pulled hair may uncover vital information. For example, if the bulb of the hair is dark, it indicates that the hair is in the anagen phase or if it is white, it indicates that the hair is in the telogen phase. | Evaluation of the pulled hair may uncover vital information. For example, if the bulb of the hair is dark, it indicates that the hair is in the [[anagen phase]], or if it is white, it indicates that the hair is in the [[telogen phase]]. | ||
'''Trichoscopy''' | '''[[Trichoscopy]]''' | ||
This is a noninvasive method of examining hair and scalp. The test may be performed with the use of a dermoscope or a video dermoscope. <ref name="pmid18664157">{{cite journal| author=Rudnicka L, Olszewska M, Rakowska A, Kowalska-Oledzka E, Slowinska M| title=Trichoscopy: a new method for diagnosing hair loss. | journal=J Drugs Dermatol | year= 2008 | volume= 7 | issue= 7 | pages= 651-4 | pmid=18664157 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18664157 }} </ref> The Alopecia Areata Predictive Score makes use of it to predict the treatment outcome in patients with patchy alopecia areata. <ref name="pmid31301100">Waśkiel-Burnat A, Rakowska A, Sikora M, Olszewska M, Rudnicka L (2020) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=31301100 Alopecia areata predictive score: A new trichoscopy-based tool to predict treatment outcome in patients with patchy alopecia areata.] ''J Cosmet Dermatol'' 19 (3):746-751. [http://dx.doi.org/10.1111/jocd.13064 DOI:10.1111/jocd.13064] PMID: [https://pubmed.gov/31301100 31301100]</ref> | This is a noninvasive method of examining hair and scalp. The test may be performed with the use of a [[dermoscope]] or a [[video dermoscope]]. <ref name="pmid18664157">{{cite journal| author=Rudnicka L, Olszewska M, Rakowska A, Kowalska-Oledzka E, Slowinska M| title=Trichoscopy: a new method for diagnosing hair loss. | journal=J Drugs Dermatol | year= 2008 | volume= 7 | issue= 7 | pages= 651-4 | pmid=18664157 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18664157 }} </ref> The Alopecia Areata Predictive Score makes use of it to predict the treatment outcome in patients with patchy alopecia areata. <ref name="pmid31301100">Waśkiel-Burnat A, Rakowska A, Sikora M, Olszewska M, Rudnicka L (2020) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=31301100 Alopecia areata predictive score: A new trichoscopy-based tool to predict treatment outcome in patients with patchy alopecia areata.] ''J Cosmet Dermatol'' 19 (3):746-751. [http://dx.doi.org/10.1111/jocd.13064 DOI:10.1111/jocd.13064] PMID: [https://pubmed.gov/31301100 31301100]</ref> | ||
'''Biopsy''' | '''[[Biopsy]]''' | ||
A biopsy will reveal the most information regarding hair loss. | A [[biopsy]] will reveal the most information regarding hair loss. | ||
'''Laboratory Tests''' | '''Laboratory Tests''' | ||
Autoantibodies, thyroid function test, ovarian hormones, free testosterone and total testosterone, luteinizing hormone, follicular stimulating hormone, complete blood count and iron panel may be useful in diagnosis. | [[Autoantibodies]], [[thyroid function test]], [[ovarian hormones]], free [[testosterone]] and total [[testosterone]], [[luteinizing hormone]], [[follicular stimulating hormone]], [[complete blood count]] and [[iron panel]] may be useful in diagnosis. | ||
'''Imaging Studies''' | '''Imaging Studies''' | ||
Chest X-ray and MRI | [[Chest X-ray]] and [[MRI]] are used in [[mycosis fungoides]] staging. This is useful in the case of [[alopecia mucinosa]]. | ||
'''Microbiology Testing''' | '''Microbiology Testing''' | ||
Potassium hydroxide preparation and fungal cultures can be used in the diagnosis of [[tinea capitis]]. | |||
'''Wood's lamp''' | '''Wood's lamp''' | ||
Wood's light can be used in diagnosis of tinea capitis. Majority of Microsporum spp will appear bluish-green, occasionally dull yellow (Microsporum gypseum) and dull blue (Trichophyton schoenleinii). However, in the U.S., under 5% of cases will show fluorescence. <ref name="pmid22972730">{{cite journal| author=Ponka D, Baddar F| title=Wood lamp examination. | journal=Can Fam Physician | year= 2012 | volume= 58 | issue= 9 | pages= 976 | pmid=22972730 | doi= | pmc=3440273 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22972730 }} </ref> | [[Wood's light]] can be used in diagnosis of [[tinea capitis]]. Majority of [[Microsporum spp]] will appear bluish-green, occasionally dull yellow (Microsporum gypseum) and dull blue (Trichophyton schoenleinii). However, in the U.S., under 5% of cases will show fluorescence. <ref name="pmid22972730">{{cite journal| author=Ponka D, Baddar F| title=Wood lamp examination. | journal=Can Fam Physician | year= 2012 | volume= 58 | issue= 9 | pages= 976 | pmid=22972730 | doi= | pmc=3440273 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22972730 }} </ref> | ||
==References== | ==References== | ||
Revision as of 02:40, 29 January 2021
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ogechukwu Hannah Nnabude, MD
Overview
The diagnostic test of choice varies with the cause of alopecia. Biopsy, laboratory tests, trichoscopy, and hair pull test are some of the techniques used in diagnosis. Chest X-ray and MRI can be used in mycosis fungoides staging and is useful for alopecia mucinosa while microscopic testing and Wood's lamp is useful for the diagnosis of fungal infection [1].
Diagnostic Test of Choice
Hair Pull Test
Test for excessive shedding, it is not diagnostic of a particular hair loss but indicates active hair loss is occurring. Hair should not be washed 24-48 hours prior to a hair pull test. It is performed by gently grasping 40-60 hairs and gently pull upward from different parts of the scalp. A positive test is when three to six or more strands are pulled out. The pull test is positive in:
- androgenetic alopecia
- alopecia areata and scarring alopecia
- telogen effluvium
- anagen effluvium
- loose anagen syndrome
Evaluation of the pulled hair may uncover vital information. For example, if the bulb of the hair is dark, it indicates that the hair is in the anagen phase, or if it is white, it indicates that the hair is in the telogen phase.
This is a noninvasive method of examining hair and scalp. The test may be performed with the use of a dermoscope or a video dermoscope. [2] The Alopecia Areata Predictive Score makes use of it to predict the treatment outcome in patients with patchy alopecia areata. [3]
A biopsy will reveal the most information regarding hair loss.
Laboratory Tests
Autoantibodies, thyroid function test, ovarian hormones, free testosterone and total testosterone, luteinizing hormone, follicular stimulating hormone, complete blood count and iron panel may be useful in diagnosis.
Imaging Studies
Chest X-ray and MRI are used in mycosis fungoides staging. This is useful in the case of alopecia mucinosa.
Microbiology Testing
Potassium hydroxide preparation and fungal cultures can be used in the diagnosis of tinea capitis.
Wood's lamp
Wood's light can be used in diagnosis of tinea capitis. Majority of Microsporum spp will appear bluish-green, occasionally dull yellow (Microsporum gypseum) and dull blue (Trichophyton schoenleinii). However, in the U.S., under 5% of cases will show fluorescence. [1]
References
- ↑ 1.0 1.1 Ponka D, Baddar F (2012). "Wood lamp examination". Can Fam Physician. 58 (9): 976. PMC 3440273. PMID 22972730.
- ↑ Rudnicka L, Olszewska M, Rakowska A, Kowalska-Oledzka E, Slowinska M (2008). "Trichoscopy: a new method for diagnosing hair loss". J Drugs Dermatol. 7 (7): 651–4. PMID 18664157.
- ↑ Waśkiel-Burnat A, Rakowska A, Sikora M, Olszewska M, Rudnicka L (2020) Alopecia areata predictive score: A new trichoscopy-based tool to predict treatment outcome in patients with patchy alopecia areata. J Cosmet Dermatol 19 (3):746-751. DOI:10.1111/jocd.13064 PMID: 31301100