Alfaxalone

	WikiDoc Resources for Alfaxalone
Articles
Most recent articles on Alfaxalone Most cited articles on Alfaxalone Review articles on Alfaxalone Articles on Alfaxalone in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Alfaxalone Images of Alfaxalone Photos of Alfaxalone Podcasts & MP3s on Alfaxalone Videos on Alfaxalone
Evidence Based Medicine
Cochrane Collaboration on Alfaxalone Bandolier on Alfaxalone TRIP on Alfaxalone
Clinical Trials
Ongoing Trials on Alfaxalone at Clinical Trials.gov Trial results on Alfaxalone Clinical Trials on Alfaxalone at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Alfaxalone NICE Guidance on Alfaxalone NHS PRODIGY Guidance FDA on Alfaxalone CDC on Alfaxalone
Books
Books on Alfaxalone
News
Alfaxalone in the news Be alerted to news on Alfaxalone News trends on Alfaxalone
Commentary
Blogs on Alfaxalone
Definitions
Definitions of Alfaxalone
Patient Resources / Community
Patient resources on Alfaxalone Discussion groups on Alfaxalone Patient Handouts on Alfaxalone Directions to Hospitals Treating Alfaxalone Risk calculators and risk factors for Alfaxalone
Healthcare Provider Resources
Symptoms of Alfaxalone Causes & Risk Factors for Alfaxalone Diagnostic studies for Alfaxalone Treatment of Alfaxalone
Continuing Medical Education (CME)
CME Programs on Alfaxalone
International
Alfaxalone en Espanol Alfaxalone en Francais
Business
Alfaxalone in the Marketplace Patents on Alfaxalone
Experimental / Informatics
List of terms related to Alfaxalone

Alfaxalone
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	N01AX05 (WHO) ;
Legal status
Legal status	US: Schedule IV ;
Pharmacokinetic data
Bioavailability	The alfaxalone molecule is solubilised using SBECD. Cyclodextrins are complex polysaccharides derived from starch that supply a hydrophobic centre for lipophilic drugs like alfaxalone.
Identifiers
	IUPAC name 3α-hydroxy-5α-pregnane-11,20-dione;
CAS Number	23930-19-0 ;
PubChem CID	104845;
ChemSpider	94637 ;
UNII	BD07M97B2A;
KEGG	D07282 ;
ChEMBL	ChEMBL190279 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C21H32O3
Molar mass	332.477 g/mol
3D model (JSmol)	Interactive image;
	SMILES O=C2[C@H]3[C@H]([C@@H]1CC[C@H](C(=O)C)[C@@]1(C)C2)CC[C@H]4C[C@H](O)CC[C@]34C;
	InChI InChI=1S/C21H32O3/c1-12(22)16-6-7-17-15-5-4-13-10-14(23)8-9-20(13,2)19(15)18(24)11-21(16,17)3/h13-17,19,23H,4-11H2,1-3H3/t13-,14+,15-,16+,17-,19+,20-,21+/m0/s1 ; Key:DUHUCHOQIDJXAT-OLVMNOGESA-N ;
(what is this?) (verify)

The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Alfaxalone (INN, JAN), also known as alphaxalone or alphaxolone (BAN), is a neuroactive steroid and general anaesthetic.^[1] It is used in veterinary practice under the trade name Alfaxan,^[2] and is licensed for use in both dogs and cats.^{[citation needed]} Along with alfadolone, it is also one of the constituents of anesthetic drug mixture althesin.

Unlike some of its predecessors alfaxalone is not associated with histamine release and anaphylaxis.^{[citation needed]}

A study 1987 found the primary mechanism for the anaesthetic action of alfaxalone to be modulation of neuronal cell membrane chloride ion transport, induced by binding of alfaxalone to GABA_A cell surface receptors. ^[3]

A 1994 study found that alfaxalone binds to a different region of this receptor than the benzodiazepines. .^[4] These benzodiazepine-insensitive GABA_A receptors are located extrasynaptically and are responsible for tonic inhibition. The occurrence of tonic GABA_A inhibition coincides with the expression of relatively rare receptor subunits, particularly the α4, α6, and δ subunits, and as a general rule-of-thumb, δ subunit-containing receptors are extrasynaptic.^[5]

Alfaxalone is metabolised rapidly in the liver. It has a very short plasma elimination half-life in dogs and cats.^{[citation needed]}

References

↑ C.R. Ganellin; David J. Triggle (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. pp. 1094–. ISBN 978-0-412-46630-4.
↑ "Alfaxalone". Drugs.com.
↑ PMID 3819824 (PMID 3819824)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand
↑ PMID 7806498 (PMID 7806498)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand
↑ Wahab A, Heinemann U, Albus K (October 2009). "Effects of gamma-aminobutyric acid (GABA) agonists and a GABA uptake inhibitor on pharmacoresistant seizure like events in organotypic hippocampal slice cultures". Epilepsy Research 86 (2-3): 113–23. doi:10.1016/j.eplepsyres.2009.05.008. PMID 19535226.

Template:General anesthetics Template:GABAAR PAMs

Template:Nervous-system-drug-stub

[GanellinTriggle1996-1] C.R. Ganellin; David J. Triggle (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. pp. 1094–. ISBN 978-0-412-46630-4.

[2] "Alfaxalone". Drugs.com.

[3] PMID 3819824 (PMID 3819824)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand

[4] PMID 7806498 (PMID 7806498)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand

[5] Wahab A, Heinemann U, Albus K (October 2009). "Effects of gamma-aminobutyric acid (GABA) agonists and a GABA uptake inhibitor on pharmacoresistant seizure like events in organotypic hippocampal slice cultures". Epilepsy Research 86 (2-3): 113–23. doi:10.1016/j.eplepsyres.2009.05.008. PMID 19535226.

[1]

[2]

[3]

[4]

[5]

Alfaxalone

Overview

See also

References

Navigation menu