Alclometasone

Alclometasone
	File:Alclometasone.png
Clinical data
Routes of; administration	topical
ATC code	D07AB10 (WHO) S01BA10 (WHO);
Identifiers
	IUPAC name [7-chloro-11-hydroxy- 10,13,16-trimethyl-3-oxo-17- (2-propanoyloxyacetyl)- 7,8,9,11,12, 14,15,16- octahydro-6H-cyclopenta[a]phenanthren-17-yl] propanoate;
CAS Number	66734-13-2;
PubChem CID	636374;
DrugBank	APRD00783;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C28H37ClO7
Molar mass	521.042 g/mol

Description

Alclometasone is synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent.
Alclometasone Dipropionate marketed as medication Aclovate by GlaxoSmithKline.

Pharmacology

Alclometasone inhibits phospholipase A2 by inducing production of lipocortins; inhibits synthesis of arachidonic acid, prostaglandins and leukotrienes acid, reduce release of cytokines from lymphocytes and others mediators of inflammation (incl. histamine).

Indications

Alclometasone cream and onintment are indicated for the relief of corticosteroid-responsive dermatoses, including:

atopic dermatitis

eczema

psoriasis

allergic dermatitis

contact dermatitis

actinic dermatitis

kiss-type allergy

skin itch
Alclometasone may be used on sensetive skin sites (face, skinfolds); in pediatric patients 1 year or older and in geriatric patients.

Contraindications

hypersensitivity to alclometasone or any of ingredients in pharmaceutical forms

cutaneous tuberculosis

chicken pox

perioral dermatitis

acne

rosacea

open wounds

trophic ulcers

viral infection of skin

skin manifestations of syphilis

Side effects

Alclometasone Adverse reactions/Side effects (sometimes, less than 1-2% cases) include:

burning

itching

erythema

skin reddening

xerodermia

skin irritation

acne

hypopigmentation

prickly heat

folliculitis

white atrophy

hypertrichosis

reinfection of skin

How supplied

Alclometasone as Aclovate® is supplied in:

Cream; Topical; 0.05%

Ointment; Topical; 0.05%

External links

Template:Corticosteroids