Adult-onset Still's disease history and symptoms: Difference between revisions

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{{Adult-onset Still's disease}}
{{Adult-onset Still’s disease}}
 
{{CMG}}; {{AE}} {{HK}}
{{CMG}}; {{AE}}


==Overview==
==Overview==
Obtaining a comprehensive history is an integral part of diagnosing adult-onset Still's disease (AOSD). The typical age of onset of adult-onset Still's disease (AOSD) is between 16 to 35 years of age. A patient suffering from AOSD may present with a [[fever]] greater than equal to 39 degrees celcius (102.2 degrees Fahrenheit) for greater than equal to 1 week along with associated [[arthralgia]]/[[arthritis]] for greater than equal to 2 weeks. There may be a [[maculopapular]] non-[[Pruritis|pruritic]] rash on the [[trunk]] or [[limbs]]. Patients may also complain of [[sore throat]] and [[lymphadenopathy]]. The [[symptoms]] of AOSD evolve over a period of weeks.


==History==
==History==
Obtaining a comprehensive history is an integral part of diagnosing adult-onset Still's disease (AOSD). The following findings on history may help identify AOSD:<ref name="pmid36592482">{{cite journal |vauthors=Wouters JM, van de Putte LB |title=Adult-onset Still's disease; clinical and laboratory features, treatment and progress of 45 cases |journal=Q. J. Med. |volume=61 |issue=235 |pages=1055–65 |date=November 1986 |pmid=3659248 |doi= |url=}}</ref>
=== Age of onset ===
* The typical age of onset of adult-onset Still's disease (AOSD) is between 16 to 35 years of age.
=== Family history ===
* Adult onset Still's disease (AOSD) is not a [[genetic]]/[[hereditary]] condition but it is known to be associated with various [[Human leukocyte antigen|HLA]] [[alleles]].
=== Initial presentation ===
* A patient suffering from AOSD may present with a [[fever]] greater than equal to 39 degrees celcius for greater than equal to 1 week along with associated [[arthralgia]]/[[arthritis]] for greater than equal to 2 weeks. There may be a [[maculopapular]] non-[[Pruritis|pruritic]] rash on the [[trunk]] or [[limbs]]. Patients may also complain of [[sore throat]] and [[lymphadenopathy]]. Physicians should rule out other causes of [[fever]] and [[arthralgia]] for example, [[septic arthritis]], [[rheumatoid arthritis]], drug reaction and [[malignancy]].
=== Past medical history ===
* The [[symptoms]] of AOSD evolve over a period of weeks.


==Symptoms==
==Symptoms==


=== Common symptoms ===
The common [[symptoms]] of AOSD include the following:<ref name="pmid16219707">{{cite journal |vauthors=Efthimiou P, Paik PK, Bielory L |title=Diagnosis and management of adult onset Still's disease |journal=Ann. Rheum. Dis. |volume=65 |issue=5 |pages=564–72 |date=May 2006 |pmid=16219707 |pmc=1798146 |doi=10.1136/ard.2005.042143 |url=}}</ref><ref name="pmid3659248">{{cite journal |vauthors=Wouters JM, van de Putte LB |title=Adult-onset Still's disease; clinical and laboratory features, treatment and progress of 45 cases |journal=Q. J. Med. |volume=61 |issue=235 |pages=1055–65 |date=November 1986 |pmid=3659248 |doi= |url=}}</ref>
* Spiking [[fever]] greater than equal to 39 C for greater than equal to 1 week
* [[Arthralgia]] for greater than equal to 2 weeks
* [[Maculopapular]] non-pruritic rash on the [[trunk]] or [[limbs]]
* [[Sore throat]]
* [[Lymphadenopathy]]
=== Less common symptoms ===
Less common [[symptoms]] of AOSD include the following:<ref name="pmid8869216">{{cite journal |vauthors=Masson C, Le Loët X, Lioté F, Renou P, Dubost JJ, Boissier MC, Brithmer L, Brégeon C, Audran M |title=Adult Still's disease: part I. Manifestations and complications in sixty-five cases in France |journal=Rev Rhum Engl Ed |volume=62 |issue=11 |pages=748–57 |date=December 1995 |pmid=8869216 |doi= |url=}}</ref>
* [[Myalgias]]
* [[Dyspnea]]
* [[Edema]]
* [[Soft tissue]] [[swelling]]


==References==
==References==

Latest revision as of 14:11, 23 April 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Syed Hassan A. Kazmi BSc, MD [2]

Overview

Obtaining a comprehensive history is an integral part of diagnosing adult-onset Still's disease (AOSD). The typical age of onset of adult-onset Still's disease (AOSD) is between 16 to 35 years of age. A patient suffering from AOSD may present with a fever greater than equal to 39 degrees celcius (102.2 degrees Fahrenheit) for greater than equal to 1 week along with associated arthralgia/arthritis for greater than equal to 2 weeks. There may be a maculopapular non-pruritic rash on the trunk or limbs. Patients may also complain of sore throat and lymphadenopathy. The symptoms of AOSD evolve over a period of weeks.

History

Obtaining a comprehensive history is an integral part of diagnosing adult-onset Still's disease (AOSD). The following findings on history may help identify AOSD:[1]

Age of onset

  • The typical age of onset of adult-onset Still's disease (AOSD) is between 16 to 35 years of age.

Family history

Initial presentation

Past medical history

  • The symptoms of AOSD evolve over a period of weeks.

Symptoms

Common symptoms

The common symptoms of AOSD include the following:[2][3]

Less common symptoms

Less common symptoms of AOSD include the following:[4]

References

  1. Wouters JM, van de Putte LB (November 1986). "Adult-onset Still's disease; clinical and laboratory features, treatment and progress of 45 cases". Q. J. Med. 61 (235): 1055–65. PMID 3659248.
  2. Efthimiou P, Paik PK, Bielory L (May 2006). "Diagnosis and management of adult onset Still's disease". Ann. Rheum. Dis. 65 (5): 564–72. doi:10.1136/ard.2005.042143. PMC 1798146. PMID 16219707.
  3. Wouters JM, van de Putte LB (November 1986). "Adult-onset Still's disease; clinical and laboratory features, treatment and progress of 45 cases". Q. J. Med. 61 (235): 1055–65. PMID 3659248.
  4. Masson C, Le Loët X, Lioté F, Renou P, Dubost JJ, Boissier MC, Brithmer L, Brégeon C, Audran M (December 1995). "Adult Still's disease: part I. Manifestations and complications in sixty-five cases in France". Rev Rhum Engl Ed. 62 (11): 748–57. PMID 8869216.

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