Adrenocortical carcinoma history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2] Ahmad Al Maradni, M.D. [3] Mohammed Abdelwahed M.D[4]


Symptoms of adrenocortical carcinoma include symptoms of androgen, glucocorticoid, mineralocorticoid, or estrogen excess. Symptoms of glucocorticoid excess include Weight gain, Acne, irritability. Symptoms of androgen excess include hirsutism, acne, and deepening of the voice. Symptoms of mineralocorticoid excess include headache, muscle weakness, Confusion, and palpitations.

Common Symptoms

60 percent of adrenocortical carcinoma (ACC) are sufficiently secretory to present clinical syndrome of hormone excess.[1]

1- Symptoms of glucocorticoid excess include: [3]

2- Symptoms of androgen excess symptoms in women include: [4]

3- Symptoms of mineralocorticoid excess include: [5]

4- Symptoms of estrogen excess in men include: [6]

5- Symptoms of catecholamines excess has been reported in adrenocortical cancers: [7]

6- Other symptoms may include: [8]

7- Children usually present with virilization (84%), while isolated glucocorticoid excess is much less common (6%). [9]


  1. Allolio B, Fassnacht M (2006). "Clinical review: Adrenocortical carcinoma: clinical update". J Clin Endocrinol Metab. 91 (6): 2027–37. doi:10.1210/jc.2005-2639. PMID 16551738.
  2. Wajchenberg BL, Albergaria Pereira MA, Medonca BB, Latronico AC, Campos Carneiro P, Alves VA; et al. (2000). "Adrenocortical carcinoma: clinical and laboratory observations". Cancer. 88 (4): 711–36. PMID 10679640.
  3. Bibek Bista & Nancy Beck (2014). "Cushing syndrome". Indian journal of pediatrics. 81 (2): 158–164. doi:10.1007/s12098-013-1203-8. PMID 24062268.
  4. Lourdes Ibanez, Ken K. Ong, Abel Lopez-Bermejo, David B. Dunger & Francis de Zegher (2014). "Hyperinsulinaemic androgen excess in adolescent girls". Nature reviews. Endocrinology. 10 (8): 499–508. doi:10.1038/nrendo.2014.58. PMID 24776733.
  5. Valeria Bisogni, Gian Paolo Rossi & Lorenzo A. Calo (2014). "Apparent mineralcorticoid excess syndrome, an often forgotten or unrecognized cause of hypokalemia and hypertension: case report and appraisal of the pathophysiology". Blood pressure. 23 (3): 189–192. doi:10.3109/08037051.2013.832967. PMID 24053336.
  6. G. M. Zanetta, M. J. Webb, H. Li & G. L. Keeney (2000). "Hyperestrogenism: a relevant risk factor for the development of cancer from endometriosis". Gynecologic oncology. 79 (1): 18–22. doi:10.1006/gyno.2000.5905. PMID 11006024.
  7. Richard Cote, Saul Suster, Lawrence Weiss, Noel Weidner (Editor). Modern Surgical Pathology (2 Volume Set). London: W B Saunders. ISBN 0-7216-7253-1.
  8. National Cancer Institute. Physician Data Query Database 2015.
  9. Stewart JN, Flageole H, Kavan P (2004). "A surgical approach to adrenocortical tumors in children: the mainstay of treatment". J Pediatr Surg. 39 (5): 759–63. PMID 15137014.