Adrenocortical carcinoma history and symptoms: Difference between revisions

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:*Coarsening of facial features
:*Coarsening of facial features
:*[[Amenorrhea|Cessation of menstruation]].  
:*[[Amenorrhea|Cessation of menstruation]].  
* [[Conn syndrome]] ([[mineralcorticoid]] excess) is marked by [[high blood pressure]], which can result in [[headache]], and [[hypokalemia]] (low serum potassium), which can produce muscle weakness, confusion, and [[palpitations]].  Low plasma [[renin]] activity, and high serum [[aldosterone]].
3-[[Mineralcorticoid]] excess symptoms include:
* [[Feminization]] ([[estrogen]] excess) is most readily noted in men, and includes [[gynecomastia|breast enlargement]], decreased [[libido]] and [[impotence]].<ref>Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL. ''Harrison's Principles of Internal Medicine''. New York: McGraw-Hill, 2005. ISBN 0-07-139140-1</ref>
:*[[Headache]]
:*[[Muscle weakness]]
:*[[Confusion]]
:*[[Palpitations]]
*[[Estrogen]] excess symptoms include: is most readily noted in men, and includes  
:*[[Gynecomastia|breast enlargement]]
:*Decreased [[libido]]
:*[[Impotence]].<ref>Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL. ''Harrison's Principles of Internal Medicine''. New York: McGraw-Hill, 2005. ISBN 0-07-139140-1</ref>


==References==
==References==

Revision as of 19:28, 25 August 2015

Adrenocortical carcinoma Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]Ahmad Al Maradni, M.D. [3]

Overview

History

Common symptoms

History and Symptoms

Adrenocortical carcinoma may present differently in children and adults. Most tumors in children are functional, and virilization is by far the most common presenting symptom, followed by Cushing's syndrome and precocious puberty. Among adults presenting with hormonal syndromes, Cushing's syndrome alone is most common, followed by mixed Cushing's and virilization (glucocorticoid and androgen overproduction). Feminization and Conn syndrome (mineralcorticoid excess) occur in less than 10% of cases. Rarely, pheochromocytoma-like hypersecretion of catecholamines has been reported in adrenocortical cancers.[1] Non-functional tumors (about 40%, authorities vary) usually present with abdominal or flank pain, or they may be asymptomatic and detected incidentally.

All patients with suspected adrenocortical carcinoma should be carefully evaluated for signs and symptoms of hormonal syndromes. This may include the followings:

1- Glucocorticoid excess symptoms include:

2-Androgen excess symptoms include:

3-Mineralcorticoid excess symptoms include:

  • Estrogen excess symptoms include: is most readily noted in men, and includes

References

  1. Richard Cote, Saul Suster, Lawrence Weiss, Noel Weidner (Editor). Modern Surgical Pathology (2 Volume Set). London: W B Saunders. ISBN 0-7216-7253-1.
  2. Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL. Harrison's Principles of Internal Medicine. New York: McGraw-Hill, 2005. ISBN 0-07-139140-1

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