Adrenocortical carcinoma causes: Difference between revisions

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__NOTOC__
__NOTOC__
{{Adrenocortical carcinoma}}
{{Adrenocortical carcinoma}}
{{CMG}} {{AE}} {{RT}}{{AAM}}
{{CMG}}; {{AE}} {{RT}} {{AAM}} {{MAD}}
==Overview==
==Overview==
There are no established causes for adrenocortical carcinoma.
There are no established causes for adrenocortical carcinoma. The relatively increased [[incidence]] in childhood is mainly explained by [[germline]] [[TP53 (gene)|TP53]] [[mutations]], which are the underlying [[Genetics|genetic]] cause of ACC in more than 50% to 80% of children.
==Causes==
==Causes==
*There are no established causes for Adrenocortical carcinoma
*There are no established causes for adrenocortical carcinoma.
*Adrenocortical carcinoma may be linked to a [[cancer]] syndrome that is passed down through families ([[inherited]])
*The relatively increased [[incidence]] in childhood is mainly explained by [[germline]] [[TP53 (gene)|TP53]] [[mutations]], which are the underlying [[Genetics|genetic]] cause of ACC in >50% to 80% of children.
 
== Genetics ==
=== Hereditary syndromes  associated with adrenocortical carcinoma are: ===
* [[Lynch syndrome]]
 
*[[Beckwith-Wiedemann syndrome]]
*[[Carney complex]]
*[[Neurofibromatosis type I|Neurofibromatosis type 1]]
*[[MEN1]]
{| style="border: 0px; font-size: 90%; margin: 3px; width: 1000px" align="center"
 
|+
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Associated conditions}}
! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|Gene mutations}}
! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|Clinical picture}}
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" |[[Lynch syndrome]]<ref name="pmid26309352">{{cite journal| author=Carethers JM, Stoffel EM| title=Lynch syndrome and Lynch syndrome mimics: The growing complex landscape of hereditary colon cancer. | journal=World J Gastroenterol | year= 2015 | volume= 21 | issue= 31 | pages= 9253-61 | pmid=26309352 | doi=10.3748/wjg.v21.i31.9253 | pmc=4541378 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26309352  }}</ref>
| style="padding: 5px 5px; background: #F5F5F5;" |
* [[MSH2]], [[MSH6]], [[MLH1]], [[PMS2]]
|
* [[Colorectal cancer]]
* [[Endometrial cancer]]
* [[Sebaceous gland carcinoma|Sebaceous neoplasms]]
* [[Ovarian cancer]]
* [[Pancreatic cancer]]
* [[Brain cancer]]
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" |[[Neurofibromatosis type I|Neurofibromatosis type 1]]
|
* [[NF1]]
|
* [[Malignant]] [[Peripheral nervous system|peripheral nerve]] [[Nerve sheath|sheet]] [[tumor]]
* [[Pheochromocytoma]]
* [[Café au lait spot|Café au lait spots]]
* [[Neurofibroma]]
* [[Optic nerve glioma|Optic glioma]]
* [[Lisch nodule]]
* Skeletal abnormalities
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" |[[Multiple endocrine neoplasia type 1|MEN1]]<ref>{{Cite journal
 
| author = [[B. Gatta-Cherifi]], [[O. Chabre]], [[A. Murat]], [[P. Niccoli]], [[C. Cardot-Bauters]], [[V. Rohmer]], [[J. Young]], [[B. Delemer]], [[H. Du Boullay]], [[M. F. Verger]], [[J. M. Kuhn]], [[J. L. Sadoul]], [[Ph Ruszniewski]], [[A. Beckers]], [[M. Monsaingeon]], [[E. Baudin]], [[P. Goudet]] & [[A. Tabarin]]
| title = Adrenal involvement in MEN1. Analysis of 715 cases from the Groupe d'etude des Tumeurs Endocrines database
| journal = [[European journal of endocrinology]]
| volume = 166
| issue = 2
| pages = 269–279
| year = 2012
| month = February
| doi = 10.1530/EJE-11-0679
| pmid = 22084155
}}</ref>               
|
* MENIN
|
* [[Foregut]] [[neuroendocrine tumors]]
* [[Pituitary tumors]]
* [[Parathyroid gland|Parathyroid]] [[hyperplasia]]
* Collagenoma
* [[Angiofibroma]]
* [[Adrenal adenoma]]/[[hyperplasia]]
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" |[[Carney complex]]
|
* [[PRKAR1A]]
|
* [[Adrenal disease]]
* [[Sertoli cell]] [[tumors]]
* [[Thyroid adenoma]]
* [[Myxoma]]
* [[Somatotrope|Somatotroph]] [[pituitary adenoma]]
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" |[[BWS]]<ref>{{Cite journal
 
| author = [[H. Segers]], [[R. Kersseboom]], [[M. Alders]], [[R. Pieters]], [[A. Wagner]] & [[M. M. van den Heuvel-Eibrink]]
| title = Frequency of WT1 and 11p15 constitutional aberrations and phenotypic correlation in childhood Wilms tumour patients
| journal = [[European journal of cancer (Oxford, England : 1990)]]
| volume = 48
| issue = 17
| pages = 3249–3256
| year = 2012
| month = November
| doi = 10.1016/j.ejca.2012.06.008
| pmid = 22796116
}}</ref>
|
* [[IGF2]], [[CDKN1C]], [[H19 (gene)|H19]]
|
* [[Wilm's tumor|Wilm’s tumor]]
* [[Hepatoblastoma]]
* [[Macrosomia]]
* [[Adrenocortical]] cytomegaly
* [[Adrenal adenoma]]
* [[Adrenal Gland|Adrenal]] [[cyst]]
* [[Hemihypertrophy]]
* [[Macroglossia]]
* [[Omphalocele]]
|}
 
==References==
==References==
{{reflist|2}}
{{reflist|2}}

Latest revision as of 15:23, 17 October 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2] Ahmad Al Maradni, M.D. [3] Mohammed Abdelwahed M.D[4]

Overview

There are no established causes for adrenocortical carcinoma. The relatively increased incidence in childhood is mainly explained by germline TP53 mutations, which are the underlying genetic cause of ACC in more than 50% to 80% of children.

Causes

  • There are no established causes for adrenocortical carcinoma.
  • The relatively increased incidence in childhood is mainly explained by germline TP53 mutations, which are the underlying genetic cause of ACC in >50% to 80% of children.

Genetics

Hereditary syndromes associated with adrenocortical carcinoma are:

Associated conditions Gene mutations Clinical picture
Lynch syndrome[1]
Neurofibromatosis type 1
MEN1[2]
  • MENIN
Carney complex
BWS[3]

References

  1. ↑ Carethers JM, Stoffel EM (2015). "Lynch syndrome and Lynch syndrome mimics: The growing complex landscape of hereditary colon cancer". World J Gastroenterol. 21 (31): 9253–61. doi:10.3748/wjg.v21.i31.9253. PMC 4541378. PMID 26309352.
  2. ↑ B. Gatta-Cherifi, O. Chabre, A. Murat, P. Niccoli, C. Cardot-Bauters, V. Rohmer, J. Young, B. Delemer, H. Du Boullay, M. F. Verger, J. M. Kuhn, J. L. Sadoul, Ph Ruszniewski, A. Beckers, M. Monsaingeon, E. Baudin, P. Goudet & A. Tabarin (2012). "Adrenal involvement in MEN1. Analysis of 715 cases from the Groupe d'etude des Tumeurs Endocrines database". European journal of endocrinology. 166 (2): 269–279. doi:10.1530/EJE-11-0679. PMID 22084155. Unknown parameter |month= ignored (help)
  3. ↑ H. Segers, R. Kersseboom, M. Alders, R. Pieters, A. Wagner & M. M. van den Heuvel-Eibrink (2012). "Frequency of WT1 and 11p15 constitutional aberrations and phenotypic correlation in childhood Wilms tumour patients". European journal of cancer (Oxford, England : 1990). 48 (17): 3249–3256. doi:10.1016/j.ejca.2012.06.008. PMID 22796116. Unknown parameter |month= ignored (help)

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