Adenocarcinoma of the lung causes: Difference between revisions

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{{CMG}}; {{AE}} {{SC}}
{{CMG}}; {{AE}} {{SC}}
==Overview==
==Overview==
Common causes of adenocarcinoma of the lung include chromosomal rearrangements and genetic mutations.<ref>{{cite book | last = Stewart | first = Bernard | title = World cancer report 2014 | publisher = International Agency for Research on Cancer,Distributed by WHO Press, World Health Organization | location = Lyon, France Geneva, Switzerland | year = 2014 | isbn = 9283204298 }}</ref>
Adenocarcinoma of the lung may caused by genetic mutations, including [[epidermal growth factor receptor|EGFR]] (7p11), [[KRAS]] (12p12), [[BRAF]] (7q34), and PIK3CA (3q26).<ref>{{cite book | last = Stewart | first = Bernard | title = World cancer report 2014 | publisher = International Agency for Research on Cancer,Distributed by WHO Press, World Health Organization | location = Lyon, France Geneva, Switzerland | year = 2014 | isbn = 9283204298 }}</ref>


==Causes==
==Causes==
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:* [[epidermal growth factor receptor|EGFR]] (7p11)
:* [[epidermal growth factor receptor|EGFR]] (7p11)
:* [[KRAS]] (12p12)
:* [[KRAS]] (12p12)
:* Translocation EML4/[[anaplastic lymphoma kinase|ALK]]
:* [[BRAF]] (7q34)
:* [[BRAF]] (7q34)
:* PIK3CA (3q26)
:* PIK3CA (3q26)
:* ERBB2 (17q12)
:* ERBB2 (17q12)
:* Translocation EML4/[[anaplastic lymphoma kinase|ALK]]
:* Tyrosine kinase fusions
:* Tyrosine kinase fusions
::* ALK (2p23), ROS1 (6q22), and RET (10q11)
::* ALK (2p23), ROS1 (6q22), and RET (10q11)

Revision as of 19:52, 14 December 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]

Overview

Adenocarcinoma of the lung may caused by genetic mutations, including EGFR (7p11), KRAS (12p12), BRAF (7q34), and PIK3CA (3q26).[1]

Causes

Genetic mutations

  • Genes involved in the pathogenesis of adenocarcinoma of the lung include:[2]
  • EGFR (7p11)
  • KRAS (12p12)
  • BRAF (7q34)
  • PIK3CA (3q26)
  • ERBB2 (17q12)
  • Translocation EML4/ALK
  • Tyrosine kinase fusions
  • ALK (2p23), ROS1 (6q22), and RET (10q11)

References

  1. Stewart, Bernard (2014). World cancer report 2014. Lyon, France Geneva, Switzerland: International Agency for Research on Cancer,Distributed by WHO Press, World Health Organization. ISBN 9283204298.
  2. Stewart, Bernard (2014). World cancer report 2014. Lyon, France Geneva, Switzerland: International Agency for Research on Cancer,Distributed by WHO Press, World Health Organization. ISBN 9283204298.


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