Adenocarcinoma of the lung causes: Difference between revisions

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{{CMG}}; {{AE}} {{SC}}
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==Overview==
==Overview==
Common causes of adenocarcinoma of the lung include chromosomal rearrangements and genetic mutations.<ref>{{cite book | last = Stewart | first = Bernard | title = World cancer report 2014 | publisher = International Agency for Research on Cancer,Distributed by WHO Press, World Health Organization | location = Lyon, France Geneva, Switzerland | year = 2014 | isbn = 9283204298 }}</ref>
[[Mutation|Genetic mutations]] are primarily responsible for the development of adenocarcinoma of the lung. [[Mutation|Genetic mutations]] of [[epidermal growth factor receptor|EGFR]] (7p11), [[KRAS]] (12p12), [[BRAF]] (7q34), and PIK3CA (3q26) play a major role in the pathogenesis of adenocarcinoma.


==Causes==
==Causes==
'''Chromosomal rearrangements'''
* Genes involved in the pathogenesis of adenocarcinoma of the lung include:<ref>{{cite book | last = Stewart | first = Bernard | title = World cancer report 2014 | publisher = International Agency for Research on Cancer,Distributed by WHO Press, World Health Organization | location = Lyon, France Geneva, Switzerland | year = 2014 | isbn = 9283204298 }}</ref><ref>{{cite book | last = Stewart | first = Bernard | title = World cancer report 2014 | publisher = International Agency for Research on Cancer,Distributed by WHO Press, World Health Organization | location = Lyon, France Geneva, Switzerland | year = 2014 | isbn = 9283204298 }}</ref><ref name="pmid17625570">{{cite journal| author=Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S et al.| title=Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. | journal=Nature | year= 2007 | volume= 448 | issue= 7153 | pages= 561-6 | pmid=17625570 | doi=10.1038/nature05945 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17625570  }} </ref><ref name="pmid22919003">{{cite journal| author=Davies KD, Le AT, Theodoro MF, Skokan MC, Aisner DL, Berge EM et al.| title=Identifying and targeting ROS1 gene fusions in non-small cell lung cancer. | journal=Clin Cancer Res | year= 2012 | volume= 18 | issue= 17 | pages= 4570-9 | pmid=22919003 | doi=10.1158/1078-0432.CCR-12-0550 | pmc=PMC3703205 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22919003  }} </ref>
* Three membrane associated tyrosine kinase receptors are recurrently involved in rearrangements in adenocarcinomas: [[anaplastic lymphoma kinase|ALK]], ROS1, and RET, and more than eighty other translocations have also been reported in adenocarcinomas of the lung.<ref>http://atlasgeneticsoncology.org/Tumors/TranslocLungAdenocarcID6751.html</ref>
:* [[epidermal growth factor receptor|EGFR]] (7p11)
 
:* [[KRAS]] (12p12)
'''Genetic mutations'''
:* [[BRAF]] (7q34)
* Genes involved in the pathogenesis of adenocarcinoma of the lung include:<ref>{{cite book | last = Stewart | first = Bernard | title = World cancer report 2014 | publisher = International Agency for Research on Cancer,Distributed by WHO Press, World Health Organization | location = Lyon, France Geneva, Switzerland | year = 2014 | isbn = 9283204298 }}</ref>
:* PIK3CA (3q26)
:* [[epidermal growth factor receptor|EGFR]] (20%)
:* ERBB2 (17q12)
:* [[HER2]] (2%)  
:* [[Chromosomal translocation|Translocation]] EML4/[[anaplastic lymphoma kinase|ALK]]
:* [[KRAS]]  
:* [[Tyrosine kinase|Tyrosine kinase fusions]]  
:* [[anaplastic lymphoma kinase|ALK]]
:* [[ALK]] (2p23), [[ROS1 (gene)|ROS1]] (6q22), and [[RET proto-oncogene|RET]] (10q11)
:* [[BRAF]]
:* PIK3CA
:* [[C-Met|MET]] (1%, associated with resistant disease)
:* ROS1


==References==
==References==

Latest revision as of 14:58, 6 March 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]

Overview

Genetic mutations are primarily responsible for the development of adenocarcinoma of the lung. Genetic mutations of EGFR (7p11), KRAS (12p12), BRAF (7q34), and PIK3CA (3q26) play a major role in the pathogenesis of adenocarcinoma.

Causes

  • Genes involved in the pathogenesis of adenocarcinoma of the lung include:[1][2][3][4]

References

  1. Stewart, Bernard (2014). World cancer report 2014. Lyon, France Geneva, Switzerland: International Agency for Research on Cancer,Distributed by WHO Press, World Health Organization. ISBN 9283204298.
  2. Stewart, Bernard (2014). World cancer report 2014. Lyon, France Geneva, Switzerland: International Agency for Research on Cancer,Distributed by WHO Press, World Health Organization. ISBN 9283204298.
  3. Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S; et al. (2007). "Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer". Nature. 448 (7153): 561–6. doi:10.1038/nature05945. PMID 17625570.
  4. Davies KD, Le AT, Theodoro MF, Skokan MC, Aisner DL, Berge EM; et al. (2012). "Identifying and targeting ROS1 gene fusions in non-small cell lung cancer". Clin Cancer Res. 18 (17): 4570–9. doi:10.1158/1078-0432.CCR-12-0550. PMC 3703205. PMID 22919003.


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