Acute viral nasopharyngitis laboratory findings: Difference between revisions
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===Viral culture=== | ===Viral culture=== | ||
*Specimens from nasal exudate can be cultured on embryonic lung cells or M-HLEA. | *Specimens from nasal exudate can be cultured on embryonic lung cells or M-HLEA. | ||
*Results are revealed after 14 days, so empiric treatment should be started without waiting for the results. | *Results are revealed after 14 days, so empiric treatment should be started without waiting for the results.<ref name="pmid17475758">{{cite journal |vauthors=Wright PF, Deatly AM, Karron RA, Belshe RB, Shi JR, Gruber WC, Zhu Y, Randolph VB |title=Comparison of results of detection of rhinovirus by PCR and viral culture in human nasal wash specimens from subjects with and without clinical symptoms of respiratory illness |journal=J. Clin. Microbiol. |volume=45 |issue=7 |pages=2126–9 |year=2007 |pmid=17475758 |pmc=1933022 |doi=10.1128/JCM.02553-06 |url=}}</ref> | ||
===PCR=== | ===PCR=== | ||
*PCR is a faster and more sensitive test than viral culture and direct antigen testing. | *PCR is a faster and more sensitive test than viral culture and direct antigen testing. | ||
*However, PCR is a very expensive diagnostic tool. So, its use should be limited to severely ill patients in whom identification of the offending organism is mandatory. | *However, PCR is a very expensive diagnostic tool. So, its use should be limited to severely ill patients in whom identification of the offending organism is mandatory.<ref name="pmid11740705">{{cite journal |vauthors=van Elden LJ, van Kraaij MG, Nijhuis M, Hendriksen KA, Dekker AW, Rozenberg-Arska M, van Loon AM |title=Polymerase chain reaction is more sensitive than viral culture and antigen testing for the detection of respiratory viruses in adults with hematological cancer and pneumonia |journal=Clin. Infect. Dis. |volume=34 |issue=2 |pages=177–83 |year=2002 |pmid=11740705 |doi=10.1086/338238 |url=}}</ref> | ||
===Other lab tests=== | ===Other lab tests=== | ||
====CBC==== | ====CBC==== | ||
Revision as of 13:11, 25 June 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Ahmed Younes M.B.B.CH [2]
Overview
Laboratory findings consistent with the diagnosis of acute viral nasopharyngitis include positive viral culture, positive PCR, and leucocytosis.
laboratory findings
Common cold is a clinical diagnosis and lab tests are usually not needed unless identification of the specific RV strain is needed.
Viral culture
- Specimens from nasal exudate can be cultured on embryonic lung cells or M-HLEA.
- Results are revealed after 14 days, so empiric treatment should be started without waiting for the results.[1]
PCR
- PCR is a faster and more sensitive test than viral culture and direct antigen testing.
- However, PCR is a very expensive diagnostic tool. So, its use should be limited to severely ill patients in whom identification of the offending organism is mandatory.[2]
Other lab tests
CBC
- CBC is nonspecific and of low value in common cold.
- CBC may show leukocytosis.
ESR and CRP:
- ESR and CRP may be elevated but this finding is highly nonspecific.
References
- ↑ Wright PF, Deatly AM, Karron RA, Belshe RB, Shi JR, Gruber WC, Zhu Y, Randolph VB (2007). "Comparison of results of detection of rhinovirus by PCR and viral culture in human nasal wash specimens from subjects with and without clinical symptoms of respiratory illness". J. Clin. Microbiol. 45 (7): 2126–9. doi:10.1128/JCM.02553-06. PMC 1933022. PMID 17475758.
- ↑ van Elden LJ, van Kraaij MG, Nijhuis M, Hendriksen KA, Dekker AW, Rozenberg-Arska M, van Loon AM (2002). "Polymerase chain reaction is more sensitive than viral culture and antigen testing for the detection of respiratory viruses in adults with hematological cancer and pneumonia". Clin. Infect. Dis. 34 (2): 177–83. doi:10.1086/338238. PMID 11740705.