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In the first three years of life megakaryoblastic leukemia is the most common type of leukemia in patients with [[Down syndrome]].<ref>Hitzler JK. (2007) Acute megakaryoblastic leukemia in Down syndrome. Pediatr Blood Cancer. Dec;49(7 Suppl):1066-9. PMID: 17943965. </ref>
In the first three years of life megakaryoblastic leukemia is the most common type of leukemia in patients with [[Down syndrome]].<ref>Hitzler JK. (2007) Acute megakaryoblastic leukemia in Down syndrome. Pediatr Blood Cancer. Dec;49(7 Suppl):1066-9. PMID: 17943965. </ref>
==Historical Perspective==
==Classification==
==Pathophysiology==
==Causes==
==Differentiating Xyz from Other Diseases==
==Epidemiology and Demographics==
==Risk Factors==
==Screening==
==Natural History, Complications, and Prognosis==
==Diagnosis==
===Diagnostic Study of Choice===
===History and Symptoms===
===Physical Examination===
===Laboratory Findings===
===Electrocardiogram===
===X-ray===
===Echocardiography and Ultrasound===
===CT scan===
===MRI===
===Other Imaging Findings===
===Other Diagnostic Studies===
==Treatment==
===Medical Therapy===
=== Interventions ===
===Surgery===
===Primary Prevention===
===Secondary Prevention===
==References==
==References==
{{reflist|2}}
{{reflist|2}}

Latest revision as of 18:48, 26 April 2021

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Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Acute megakaryoblastic leukemia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Acute megakaryoblastic leukemia (AMKL) is a form of leukemia where a majority of the blasts are megakaryoblastic.[1]

This rare subtype of acute myeloid leukemia (AML) was first reported in 1931 by Von Boros and his colleagues.[2]

It is classified under M7 in the French-American-British classification.[3] Subsequently, it was introduced in the WHO 2008 classification of myeloid neoplasms and acute leukemia.[4]

In the first three years of life megakaryoblastic leukemia is the most common type of leukemia in patients with Down syndrome.[5]


Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Xyz from Other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications, and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography and Ultrasound

CT scan

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Interventions

Surgery

Primary Prevention

Secondary Prevention

References

  1. "Final Diagnosis -- Case 439". Retrieved 2008-03-08.
  2. Oki, Yasuhiro; Kantarjian, Hagop M.; Zhou, Xian; Cortes, Jorge; Faderl, Stefan; Verstovsek, Srdan; O'Brien, Susan; Koller, Charles; Beran, Miloslav; Bekele, B. Nebiyou; Pierce, Sherry; Thomas, Deborah; Ravandi, Farhad; Wierda, William G.; Giles, Francis; Ferrajoli, Alessandra; Jabbour, Elias; Keating, Michael J.; Bueso-Ramos, Carlos E.; Estey, Elihu; Garcia-Manero, Guillermo (2006). "Adult acute megakaryocytic leukemia: an analysis of 37 patients treated at M.D. Anderson Cancer Center". Blood. 107 (3): 880–884. doi:10.1182/blood-2005-06-2450. ISSN 0006-4971.
  3. Bennett, John M. (1985). "Criteria for the Diagnosis of Acute Leukemia of Megakaryocyte Lineage (M7)". Annals of Internal Medicine. 103 (3): 460. doi:10.7326/0003-4819-103-3-460. ISSN 0003-4819.
  4. Vardiman, James W.; Thiele, Jüergen; Arber, Daniel A.; Brunning, Richard D.; Borowitz, Michael J.; Porwit, Anna; Harris, Nancy Lee; Le Beau, Michelle M.; Hellström-Lindberg, Eva; Tefferi, Ayalew; Bloomfield, Clara D. (2009). "The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes". Blood. 114 (5): 937–951. doi:10.1182/blood-2009-03-209262. ISSN 0006-4971.
  5. Hitzler JK. (2007) Acute megakaryoblastic leukemia in Down syndrome. Pediatr Blood Cancer. Dec;49(7 Suppl):1066-9. PMID: 17943965.

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