Acute lymphoblastic leukemia: Difference between revisions

Jump to navigation Jump to search
No edit summary
No edit summary
Line 14: Line 14:


==[[Acute lymphoblastic leukemia overview|Overview]]==
==[[Acute lymphoblastic leukemia overview|Overview]]==
Acute lymphoblastic leukemia was first described in 1827 by a french physician named [[Alfred-Armand-Louis-Marie Velpeau]]
Acute lymphoblastic leukemia was first described in 1827 by a french physician named [[Alfred-Armand-Louis-Marie Velpeau]].


==[[Acute lymphoblastic leukemia historical perspective|Historical Perspective]]==
==[[Acute lymphoblastic leukemia historical perspective|Historical Perspective]]==

Revision as of 13:01, 31 August 2015

Acute lymphoblastic leukemia

Acute lymphoblastic leukemia Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Differentiating Acute lymphoblastic leukemia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

Bone X Ray

Echocardiograph and Ultrasound

CT

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Acute lymphoblastic leukemia On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Acute lymphoblastic leukemia

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Acute lymphoblastic leukemia

CDC on Acute lymphoblastic leukemia

Acute lymphoblastic leukemia in the news

Blogs on Acute lymphoblastic leukemia

Directions to Hospitals Treating Acute lymphoblastic leukemia

Risk calculators and risk factors for Acute lymphoblastic leukemia

For patient information click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2] Carlos A Lopez, M.D. [3]

Synonyms and keywords: Acute lymphocytic leukemia, Acute lymphoid leukemia, ALL

Overview

Acute lymphoblastic leukemia was first described in 1827 by a french physician named Alfred-Armand-Louis-Marie Velpeau.

Historical Perspective

  • In 1845, a series of patients who died with enlarged spleens and changes in the "colors and consistencies of their blood" was reported by the Edinburgh-based pathologist J.H. Bennett; he used the term "leucocythemia" to describe this pathological condition.[2]
  • The term "leukemia" was coined by Rudolf Virchow, the renowned German pathologist, in 1856. As a pioneer in the use of the light microscope in pathology, Virchow was the first to describe the abnormal excess of white blood cells in patients with the clinical syndrome described by Velpeau and Bennett. As Virchow was uncertain of the cause of the white blood cell excess, he used the purely descriptive term "leukemia" (Greek: "white blood") to refer to the condition.[3]
  • The term "myeloid" was coined by Neumann in 1869, as he was the first to recognize that white blood cells were made in the bone marrow (Greek: µυєλός, myelos = (bone) marrow) as opposed to the spleen.
  • Finally, in 1900 the myeloblast, which is the malignant cell in AML, was characterized by Naegeli, who divided the leukemias into myeloid and lymphocytic.[6]

[7]

Classification

Pathophysiology

Differentiating Acute lymphoblastic leukemia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | CT | MRI | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Template:Hematology


Template:WikiDoc Sources

  1. Hoffman, Ronald; et al. (2005). Hematology: Basic Principles and Practice (4th. ed. ed.). St. Louis, Mo.: Elsevier Churchill Livingstone. pp. p. 1071. ISBN 0-443-06629-9.
  2. Bennett JH. Two cases of hypertrophy of the spleen and liver, in which death took place from suppuration of blood. Edinburgh Med Surg J. (1845)64:413.
  3. Virchow R: Die Leukämie. In Virchow R (ed): Gesammelte Abhandlungen zur Wissenschaftlichen Medizin. Frankfurt, Meidinger, 1856, p 190.
  4. Ebstein W. Ueber die acute Leukämie und Pseudoleukämie. Deutsch Arch Klin Med. (1889)44:343.
  5. Mosler F. Klinische Symptome und Therapie der medullären Leukämie. Berl Klin Wochenschr. (1876)13:702.
  6. Naegeli O. Über rothes Knochenmark und Myeloblasten. Deutsch Med Wochenschr. (1900) 26:287.
  7. Zhen-yi, Wang (2003). "Ham-Wasserman Lecture: Treatment of Acute Leukemia by Inducing Differentiation and Apoptosis". Hematology. PMID 14633774.