Acute disseminated encephalomyelitis epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sujaya Chattopadhyay, M.D.[2]
Overview
The average annual incidence of ADEM is between 0.07 and 0.6 per 1,00,000 individuals per year. It is more common during childhood, with a median age on onset between 5-8 years and a male predominance (1.8:1).
Epidemiology and Demographics
Epidemiology
- Average annual incidence is between 0.07 and 0.6 per 1,00,000 individuals per year[1] [2][3].
- Population-based studies revealed a slightly lower incidence in the US and UK compared to Asian countries. The incidence of pediatric ADEM varies between 0.47/100000 and 0.64/100000 in the Asian countries [2][3] compared to 0.07/100000 and 0.30/100000 in Europe and San Diego [3][4][5] .
- The incidence seems to be increasing with the distance from the Equator[6].
Demographics
- ADEM is more common during childhood with a median age of onset between 5-8 years and a male predominance (1.8:1)[7].
- The adult age of presentation ranges from 33 to 41 years without any gender preference.
- No specific ethnic distribution has been described.
References
- ↑ Xiong CH, Yan Y, Liao Z, Peng SH, Wen HR, Zhang YX; et al. (2014). "Epidemiological characteristics of acute disseminated encephalomyelitis in Nanchang, China: a retrospective study". BMC Public Health. 14: 111. doi:10.1186/1471-2458-14-111. PMC 3922734. PMID 24495742.
- ↑ 2.0 2.1 Torisu H, Kira R, Ishizaki Y, Sanefuji M, Yamaguchi Y, Yasumoto S; et al. (2010). "Clinical study of childhood acute disseminated encephalomyelitis, multiple sclerosis, and acute transverse myelitis in Fukuoka Prefecture, Japan". Brain Dev. 32 (6): 454–62. doi:10.1016/j.braindev.2009.10.006. PMID 19942388.
- ↑ 3.0 3.1 3.2 Pohl D, Hennemuth I, von Kries R, Hanefeld F (2007). "Paediatric multiple sclerosis and acute disseminated encephalomyelitis in Germany: results of a nationwide survey". Eur J Pediatr. 166 (5): 405–12. doi:10.1007/s00431-006-0249-2. PMID 17219129.
- ↑ Leake JA, Albani S, Kao AS, Senac MO, Billman GF, Nespeca MP; et al. (2004). "Acute disseminated encephalomyelitis in childhood: epidemiologic, clinical and laboratory features". Pediatr Infect Dis J. 23 (8): 756–64. doi:10.1097/01.inf.0000133048.75452.dd. PMID 15295226.
- ↑ Gudbjornsson BT, Haraldsson Á, Einarsdóttir H, Thorarensen Ó (2015). "Nationwide Incidence of Acquired Central Nervous System Demyelination in Icelandic Children". Pediatr Neurol. 53 (6): 503–7. doi:10.1016/j.pediatrneurol.2015.08.020. PMID 26463471.
- ↑ Pellegrino P, Radice S, Clementi E (2014). "Geoepidemiology of acute disseminated encephalomyelitis". Epidemiology. 25 (6): 928–9. doi:10.1097/EDE.0000000000000176. PMID 25265138.
- ↑ Tenembaum S, Chamoles N, Fejerman N (2002). "Acute disseminated encephalomyelitis: a long-term follow-up study of 84 pediatric patients". Neurology. 59 (8): 1224–31. doi:10.1212/wnl.59.8.1224. PMID 12391351.