Acronyms of Clinical Trial Terms

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4S Scandinavian simvastatin survival study;
6C trial cooperative colorectal cancer combination chemotherapy clinical;
AAASPS African-American antiplatelet stroke prevention study;
AASK African-American study of kidney disease and hypertension
ABC study Association of Black Cardiologists study of hypertension;
ABCD alternans before cardioverter-defibrillator
appropriate blood pressure control in diabetes
AbESTT abciximab [ReoPro™] in emergent stroke treatment trial
ACADEMIC azithromycin in coronary artery disease: elimination of myocardial infection with chlamydia
ACAS asymptomatic carotid atherosclerosis study;
ACCENT A Crohn's disease clinical trial evaluating infliximab in a new long-term treatment regimen
ACCESS acute candesartan cilexetil evaluation in stroke survivors
a case control etiological study of sarcoidosis
ACCORD action to control cardiovascular risk in diabetes
ACES Avelox™ clinical experience study
azithromycin and coronary events study
ACME angioplasty compared to medicine
ACIP asymptomatic cardiac ischemia pilot study
ACRE appropriateness of coronary revascularization
ACST asymptomatic carotid surgery trial
ACT angioplasty compliance trial
attacking claudication with ticlopidine
ACTION a clinical trial in overt nephropathy;
actinomycin eluting stent improves outcomes by reducing neointimal hyperplasia
a coronary disease trial investigating outcome with nifedipine GITS
ACUTE analysis of coronary ultrasound thrombolysis endpoints in acute myocardial infarction; Angiosonics
assessment of cardioversion utilizing transesophageal echocardiography;
ADAM Amsterdam duration of antiretroviral medication study
aneurysm detection and management study
ADAPT Alzheimer's disease anti-inflammatory prevention trial;
ADCS Alzheimer's disease cooperative study
ADEMEX adequacy of peritoneal dialysis in Mexico; sponsor: Baxter Healthcare Corporation
ADEPT advanced elements of pacing trial; sponsor: Medtronic
ADMIRAL abciximab before direct angioplasty and stenting in myocardial infarction regarding acute and long-term followup
ADMIT arterial disease multiple intervention trial
ADONIS aspirin dose optimized in noncardioembolic ischemic stroke
ADOPT a diabetes outcome progression trial;
ADOPT-A atrial dynamic overdrive pacing trial-A
ADVANCE a dosing evaluation of a vasopressin antagonist in CHF patients undergoing exercise
AEGIS alternative graft investigational study;
AFCAPS Air Force coronary atherosclerosis prevention study
AFFIRM atrial fibrilation followup: investigation of rhythm management
AFIB atrial fibrillation investigation with bidisomide
AGENT angiogenic gene therapy
AGIS advanced glaucoma intervention study
A-HeFT African-American heart failure trial;
AIR aerosolized iloprost randomized placebo-controlled study; sponsor: Schering AG
AIST-ASH acute ischemic stroke trial: oral aspirin vs intravenous heparin on stroke progression
ALERT adjunctive Lamictal® in epilepsy and response to treatment
assessment of Lescol® in renal transplantation
ALIVE adenosine lidocaine infarct zone viability enhancement
amiodarone versus lidocaine in prehospital ventricular fibrillation evaluation; sponsor: Wyeth Pharmaceuticals
azimilide postinfarct survival evaluation;
ALLHAT antihypertensive and lipid-lowering treatment to prevent heart attack trial;
ALLIANCE aggressive lipid lowering to alleviate new cardiovascular endpoints
ALTS ASCUS/LSIL triage study
[ASCUS - atypical squamous cells of undetermined significance; LSIL - low-grade squamous intraepithelial lesion]
AMAZE a multicenter trial using Atacand®-Zestril®* versus Zestril to evaluate the effects on lowering blood pressure [*Atacand as add-on therapy with Zestril]
AMIGO AC2993: diabetes management for improving glucose outcomes; sponsor: Amylin Pharmaceuticals, Inc.
AMISTAD acute myocardial infarction study of adenosine;
APASS antiphospholipid antibody stroke study
APC adenoma prevention with celecoxib;
APOCARD Apomate™ imaging in cardiac transplant patients
APRES angiotensin-converting enzyme inhibition post revascularization study
ARCH amiodarone reduction in coronary heart
ARCHeR Acculink™ for revascularization of carotids in high-risk patients
AREDS age-related eye disease study
ARIC atherosclerosis risk in communities
ARMS APSAC reocclusion multicenter study
ARREST AngioRad™ radiation for restenosis;
ARTISTIC AngioRad™ radiation therapy for in-stent restenosis intracoronary;
ASAP azimilide supraventricular arrhythmia program;
ASCENT ACS stent clinical equivalence in de novo lesions trial
ASCOT Anglo-Scandinavian cardiac outcome trial
ASPECT anticoagulants in the secondary prevention of events in coronary thrombosis;
ASPEN atorvastatin [Lipitor™] study for the prevention of endpoints for patients with NIDDM
ASSENT assessment of the safety and efficacy of a new thrombolytic [TNKase™];
ASTIS autologous stem cell transplantation international scleroderma trial
ASTRID atrial sensing trial to prevent inappropriate detections
ASTRONAUT acid suppression trial: ranitidine [Zantac®] versus omeprazole [Prilosec®] for NSAID-associated ulcer treatment
ATAC Arimidex (anastrozole), tamoxifen and combination therapy
Arimidex (anastrozole) and tamoxifen alone or in combination
ATBAT anticoagulant therapy with bivalirudin [Angiomax™] to assist in PCI 1st inning trial (PCI in HIT/HITTS)
ATICH antifibrinolytic therapy in acute intracerebral hemorrhage
ATLAS Acolysis during treatment of lesions affecting saphenous vein bypass grafts; Angiosonics' Acolysis System™
assessment of treatment with lisinopril and survival;
ATLANTIC angina treatments – lasers and normal therapies in comparison
ATLANTIS alteplase thrombolysis for acute noninterventional therapy in ischemic stroke
AT LAST antiretroviral trial looking at sex and treatment
AtoZ Aggrastat® to Zocor® study; sponsor: Merck
ATRIA anticoagulation and risk factors in atrial fibrillation
ATS amblyopia treatment study
ATTRACT anti-TNF trial in rheumatoid arthritis with cA2 treatment;
anti-TNF trial in rheumatoid arthritis with concomitant therapy
AVASIS aspirin versus anticoagulants in symptomatic intracranial stenosis
AVERT artificial valve endocarditis reduction trial
atorvastatin versus revascularization treatments
AVID antiarrhythmics versus implantable defibrillators
AWESOME angina with extremely serious operative mortality evaluation
AZACS azithromycin in acute coronary syndromes
BARI
BARI 2D
bypass angioplasty revascularization investigation
bypass angioplasty revascularization investigation 2 diabetes;
BARS Beaumont alcohol restenosis study
BASC blood pressure in acute stroke collaboration
BATMAN BiodivYsio® 'bat'imastat SV stent versus balloon angioplasty for the reduction of restenosis in small coronary arteries;
BCPT breast cancer prevention trial
BEAT bucindolol evaluation in acute myocardial infarction trial;
BECAIT bezafibrate coronary atherosclerosis intervention trial
BELLES beyond endorsed lipid lowering with EBCT scannings
BENEFIT Betaferon® [Betaseron® in U.S.] in newly emerging MS for initial treatment; information
BENESTENT Belgium Netherlands stent
BERT beta energy restenosis trial;
BESMART beStent™ in small arteries
BEST beta-blocker evaluation of survival trial;
BEST-ICD beta-blocker evaluation of survival trial plus ICD
BETTER beta radiation trial to eliminate restenosis;
BHACAS beating heart against cardioplegic arrest studies
BIP bezafibrate infarction prevention
BLIND-DATE blinded withdrawal of deprenyl in the DATATOP extension trial
BLOSS beta blocker length of stay study
BPAV balloon prophylaxis of aneurysmal vasospasm
BRAINS Bayer randomized acute ischemia neuroprotectant study
biochemical research and information study
BRAVO beta radiation for treatment of arteriovenous graft outflow; sponsor: Novoste Corporation [Corona™ system]
blockade of the GP IIb/IIIa receptor to avoid vascular occlusion;
BREATHE-1 bosentan [Tracleer™]: randomized trial of endothelin receptor antagonist therapy for pulmonary hypertension
BRILLIANT batimastat (BB-94) antirestenosis trial utilizing the BiodivYsio® local drug delivery PC stent;
BRITE
BRITE-SVG
beta radiation to reduce in-stent restenosis;
beta radiation to reduce in-stent restenosis for saphenous vein bypass grafts
CABERNET carotid artery revascularization using the Boston Scientific EPI FilterWire EX and the EndoTex NexStent
CACHET comparison of abciximab complications with Hirulog® [Angiomax™ as of 1999] ischemic events trial
CADILLAC controlled abciximab [ReoPro™] and device investigation to lower late angioplasty complications
CAESAR Canada, Australia, Europe, South Africa AIDS study;
CALM candesartan and lisinopril microalbuminuria study
CALM-PD comparison of the agonist pramipexole vs. levodopa on motor complications in Parkinson disease
CALYPSO cylexin as an adjunct to lytic therapy to prevent superoxide reflow injury
CAMELOT comparison of amlodipine versus enalapril [Lipitor®] to limit occurrences of thrombosis
CAMEO cerebral aneurysm multicenter European Onyx™
CANDLE candesartan versus losartan efficacy comparison;
CAPARES coronary angioplasty amlodipine restenosis study
CAPRICORN carvedilol post infarction survival control in left ventricular dysfunction
CAPRIE clopidogrel versus aspirin in patients at risk of ischemic events;
CAPT complications of AMD [age-related macular degeneration] prevention trial
CAPTEN captopril after thrombolysis trial;
CAPTIM comparison of angioplasty and prehospital thrombolysis in acute myocardial infarction
CAPTIN captopril before reperfusion in acute myocardial infarction
captopril plus tissue plasminogen activator following acute myocardial infarction
CAPTURE c7E3 antiplatelet therapy in unstable refractory angina
CARDIA coronary artery risk development in young adults
CARDS collaborative atorvastatin [Lipitor™]and diabetes study
CARE calcium antagonist in reperfusion;
cholesterol and recurrent events;
carvedilol atherectomy restenosis;
CARE-HD coenzyme Q10 and remacemide: evaluation in Huntington disease
CARE-HF cardiac resynchronization - heart failure; European complement to U.S./Canada MIRACLE study
CARISA combination assessment of ranolazine in stable angina;
CARMEN carvedilol ACE inhibitors remodelling mild heart failure evaluation
CART Canadian antioxidant restenosis trial
CASES Canadian activase for stroke effectiveness study
CASH cardiac arrest study-Hamburg
CAST cardiac arrhythmia suppression trial;
CASTLE candesartan amlodipine study of tolerability and efficacy
CAT Chinese ACE inhibitor in acute myocardial infarction trial
cardiomyopathy trial
CATAPULT cisplatin and tirapazamine in subjects with advanced previously untreated non–small cell lung tumors
CATIE clinical antipsychotic trials of intervention effectiveness; see trial information
CATS Canadian American ticlopidine study
captopril and thrombolysis study
CAVATAS carotid and vertebral artery transluminal angioplasty study
CBT-CD cognitive behavior therapy for the chronic depressions;
CEDARS comprehensive evaluation of defibrillators and resuscitative shock
CEOS congenital esotropia observational study
CHAMP children's HIV and AIDS model program
combination chemotherapy and mortality prevention
CHAMPIONS controlled high-risk subjects Avonex™ MS prevention in ongoing neurologic surveillance
CHAMPS controlled high-risk subjects Avonex™ MS prevention study
CHARM candesartan cilexitil [Atacand™] in heart failure assessment of reduction mortality and morbidity
CHEESE comparative trial of HIV-infected patients evaluating efficacy and safety of saquinavir-enhanced oral formulation and indinavir given as part of a triple drug therapy;
CHF-STAT congestive heart failure survival trial of antiarrhythmic therapy
CHRISTMAS carvedilol hibernation reversible ischemia trial; marker of success
CHS cardiovascular health study
Charleston heart study
community health study
Congenital Heart Surgeons Society study
coronary heart study
CIBIS cardiac insufficiency bisoprolol study
CIDS Canadian implantable defibrillator study; sponsor: Medtronic
CIGTS collaborative initial glaucoma treatment study
CLASS celecoxib [Celebrex®] long-term arthritis safety study
clomethiazole acute stroke study
CLASSICS clopidogrel [Plavix™] aspirin stent international cooperative study
CLASS-IHT clomethiazole acute stroke study in ischemic, hemorrhagic, and tPA treated stroke
CLEERE collaborative longitudinal evaluation of ethnicity and refractive error
COAST heparin-coated stents in small coronary arteries
COCAD cognitive outcomes in coronary artery disease
COLA carvedilol open label assessment
COMBINE combining medications and behavorial interventions;
COMET carvedilol or metoprolol European trial
COMMA compliment inhibition in myocardial infarction treated with percutaneous transluminal coronary angioplasty [evaluation of IV dosing regimens of h5G1.1-scFv]; sponsors: Procter & Gamble and Alexion Pharmaceuticals
COMPANION comparison of medical therapy, pacing and defibrillation in chronic heart failure; Guidant Corporation
COMPLY compliment inhibition in myocardial infarction treated with thrombolytics [evaluation of IV dosing regimens of h5G1.1-scFv]; sponsors: Procter & Gamble Pharmaceuticals and Alexion Pharmaceuticals
COMS collaborative ocular melanoma study
CONVINCE controlled onset verapamil investigation of cardiovascular endpoints
COOL cardiovascular thrombolytic to open occluded lines [t-PA]
COOL AID cooling for acute ischemic brain damage;
COOL MI cooling as an adjunctive therapy to percutaneous intervention in patients with acute myocardial infarction;
COPERNICUS carvedilol [Coreg®] prospective randomized cumulative survival
COPPA clinical outcomes from the prevention of postoperative arrhythmia
CORE continuing outcomes relevant to Evista™
COSS carotid occlusion surgery study
COURAGE clinical outcomes utilizing revascularization and aggressive drug evaluation;
COURT a randomized trial of contrast media utilization in high risk PTCA
CRASH corticosteroid randomization after significant head injury
CREDO clopidogrel [Plavix™] for reduction of events during observation
CREST carotid revascularization endarterectomy vs stenting trial
CRUISE can routine ultrasound influence stent expansion
CURE clopidogrel in unstable angina to prevent recurrent ischemic events
DAIS diabetes atherosclerosis intervention study
DAISY diabetes autoimmunity study in the young
DATATOP deprenyl and tocopherol antioxidative therapy of parkinsonism
DAVID dual-chamber and VVI implantable defibrillator; see
DEBATE Doppler endpoints balloon angioplasty trial Europe;
DECOPI la desobstruction coronaire en post-infarctus
DEFINITE defibrillators in nonischemic cardiomyopathy treatment evaluation
DEFUSE diffusion-weighted imaging evaluation for understanding stroke evaluation;
DESTINI-CFR Doppler endpoints stenting international investigation - coronary flow reserve;
DIADS depression in Alzheimer disease study
DIAGNOSIS diffusion-weighted imaging assessment of the genuine need for other studies in ischemic stroke
DIAMOND distensibility improvement with ALT-711 remodeling in diastolic heart failure; sponsor: Alteon Inc.
DIAMOND CHF Danish investigators of arrhythmia and mortality on dofetilde congestive heart failure;
DIGAMI diabetes mellitus insulin-glucose infusion in acute myocardial infarction
DMIST digital mammographic imaging screening trial
DINAMIT defibrillation in acute myocardial infarction trial
DIRECT diabetic retinopathy candesartan trial; candesartan cilexetil (Atacand®)
DIRECTOR direct stenting study with Orbus R stent™; sponsor: Orbus Medical Technologies
DISC disability in strategies for care
DISTINCT BiodivYsio™ stent in controlled trial
DPT-1 diabetes prevention trial - type 1;
DREAM diabetes reduction approaches with ramipril and rosiglitazone medications
DYSBOT Dysport and Botox study;
EAGAR estrogen and graft atherosclerosis research trial
EARS European atherosclerosis research study
ECCO 2000 effects of citicoline (CerAxon™) on clinical outcome - 2000 mg;
EDGE™ evaluation of daptomycin [Cidecin™] in gram-positive entities
EDGECAP evaluation of daptomycin [Cidecin™] in gram-positive entities in the treatment of community-acquired pneumonia
EDGESST evaluation of daptomycin [Cidecin™] in gram-positive entities in the treatment of complicated skin and soft tissue infections
EDGEUTI evaluation of daptomycin [Cidecin™] in gram-positive entities in the treatment of complicated urinary tract infection
ED-IMPACT emergency department impedance cardiography-aided assessment changes therapy; sponsor: CardioDynamics International
EFICAT ejection fraction in cardiac transplant patients
EGASIS early GABA-ergic activation sin troke
ELECT evaluating enoxaparin [Lovenox®] clotting times; see
ELITE evaluation of losartan in the elderly
ELLDOPA earlier versus later levodopa in Parkinson disease
ENABLE endothelin antagonist bosentan for lowering cardiac events in heart failure
ENCORE evaluation of nifedipine and cerivastatin on the recovery of endothelial function; web site
ENRICHD enhancing recovery in coronary heart disease
ENTIRE enoxaparin and TNK-tPA with or without GP IIb/IIIa inhibitor as reperfusion strategy in ST elevation MI [TIMI-23];
EPHESUS eplerenone neurohormonal efficacy and survival study;
eplerenone post-AMI heart failure efficacy and survival study
EPIC evaluation of c7E3 for prevention of ischemic complications
EPILOG evaluation in PTCA to improve long-term outcome with abciximab GP IIb/IIIa blockade;
EPISTENT evaluation of platelet IIb/IIIa inhibitor for stenting trial
ERA early rheumatoid arthritis (RA) study
enoxaparin restenosis after angioplasty study
estrogen replacement and atherosclerosis study
ERASE emergency room assessment of sestamibi for evaluation of chest pain
ERGO etomoxir for the recovery of glucose oxidation
ER-TIMI early Retavase™ - thrombolysis in myocardial infarction
ESCAPE evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness
ESPRIT enhanced suppression of the platelet IIb/IIIa receptor with Integrilin™ therapy
European study of the prevention of reocclusion after initial thrombolysis
evaluation of subcutaneous proleukin in a randomized international trial
ESPS2 European stroke prevention study 2
ESSENCE efficacy and safety of subcutaneous enoxaparin in non–Q-wave coronary events;
ESSENTIAL the studies of oral enoximone therapy in advanced heart failure; sponsor: Myogen, Inc.
ETHECC evaluation of Thymitaq™ in hepatocellular carcinoma; sponsor: Eximas Pharmaceutical Corporation
ETROP early treatment of retinopathy of prematurity
Euro-SPAH European-sonotherapy prevention of arterial hyperplasia; sponsor: PharmaSonics, Inc.
EVIDENCE evidence for interferon dose-effect: European-North American comparative efficacy study [Rebif® v. Avonex™ in relapsing-remitting multiple sclerosis (RRMS)]
EVIDENT endovascular investigation determining the safety of a new tacrolimus-eluting stent graft; sponsor: JOMED N.V.
EXCITE evaluation of oral xemilofiban in controlling thrombotic events;
EXCITe extremity constraint-induced therapy
EXCLAIM extended clinical prophylaxis in acutely ill medical patients [Lovenox™ (enoxaparin) postmarketing (phase IV) trial]; sponsor: Aventis
FACET fosinopril versus amlodipine cardiovascular events randomized trial
FAME fluvastatin [Lescol®] assessment of morbi-mortality in the elderly
FASTER fibrinolytic and Aggrastat® ST elevation resolution;
first abarelix depot study for treating endometriosis rapidly
first and second trimester evaluation of risk; see study information
FAST-MAG field administration of stroke therapy - magnesium
FIELD fenofibrate [TriCor®] intervention and event lowering in diabetes
FIRST Flolan (dobutamine) international randomized survival trial
first trimester integrated risk screening for trisomy [information]
FLARE fluvastatin [Lescol®] angiographic restenosis
FOOD feed or ordinary diet
FOSIT Fosamax® international trial
FRAXIS / FRAX.I.S. Fraxiparine® in ischemic syndromes
FRIC Fragmin® in unstable coronary artery disease
FRISC fast revascularization during instability in coronary artery disease
Fragmin® during instability in coronary artery disease
FROSTY Freezor™ trial of supraventricular tachycardia
FUSION fractional flow reserve and ultrasound indices for objective narrowing assessment
GART study genotypic antiretroviral resistance testing
GEMS 'Ginkgo biloba 'evaluation memory study
GISEN gruppo Italiano di studi epidemiologici in nefrologia
GUSTO global utilization of streptokinase and tPA for occluded arteries;
GUSTO-SPEED global utilization of streptokinase and tPA for occluded arteries–strategies for patency enhancement in the emergency department
HALT-C hepatitis C antiviral long-term treatment to prevent cirrhosis;
HANDLS health aging in nationally diverse longitudinal samples
HARDBALL heart allograft rejection: detection with breath alkanes in low levels
HeADDFIRST hemicraniectomy and durotomy for deterioration from infarction relating swelling trial
HEART healing and early afterload reducing therapy
HEAT 2 hypertension endothelin antagonist treatment
HEME hemorrhage early MRI evaluation
HERO Hirulog® early reperfusion/occlusion trial
HERS heart and estrogen/progestin replacement study
HIV epidemiology research study
HESTIA home evaluation of stroke induced aid
HIPS heparin infusion prior to stenting;
HIT HDL-cholesterol intervention trial
hirudin for the improvement of thrombolysis
HOPE heart outcomes prevention evaluation;
HOPE-TOO heart outcomes prevention evaluation - the ongoing outcomes
HORIZON health outcomes and reduced incidence with zoledronic once yearly
HOT hypertension optimum treatment
HPS heart protection study
HRS health and retirement study
HYVET hypertension in the very elderly trial
ICE-IT intravascular cooling adjunctive to primary coronary intervention
ICSS international carotid stenting study (CAVATAS-2)
IDEAL incremental decrease in endpoints through aggressive lipid lowering
Iressa® dose evaluation in advanced lung cancer
IDNT irbesartan [Avapro®] in diabetic nephropathy trial
IHAST intraoperative hypothermia for aneurysm surgery trial
IMAGES intravenous magnesium efficacy in stroke
IMAGINE ischemic management with Accupril™ post bypass graft via inhibition of converting enzyme
IMPACT Integrilin™ to manage platelet aggregation to prevent coronary thrombosis
international mexiletine or placebo antiarrhythmic coronary trial;
international multiple sclerosis secondary progressive Avonex™ controlled trial
IMPRESS inhibition of metalloprotease by BMS-186716 in a randomized exercise and symptoms study;
IMS interventional management of stroke study
INCOMIN independent comparison of interferon [Betaseron® v. Avonex™ in relapsing-remitting multiple sclerosis (RRMS)]
InDDEx investigation into delay to diagnosis of Alzheimer disease with Exelon™
INHIBIT intimal hyperplasia inhibition with beta in-stent trial; Guidant Corporation
INSIGHT international nifedipine once-daily study – intervention as a goal in hypertension treatment; web site
INTACT Iressa® non–small cell lung cancer trial assessing combination treatment
INTEGRITI Integrilin® and tenecteplase [TNKase™] in acute myocardial infarction;
InTIME intravenous nPA for treatment of infarcting myocardium early;
INTrEPID investigation of non–transplant-eligible patients who are inotrope dependent; see
INTRO-AMI Integrilin® and reduced dose of thrombolytic in acute myocardial infarction
IONA impact of nicorandil in angina
IONDT ischemic optic neuropathy decompression trial
IRAS insulin resistance atherosclerosis study
IRMA 2 irbesartan [Avapro®] microalbuminuria type 2
IRIS Isostent for restenosis intervention study
ISAAC international study of asthma and allergies in childhood
ISAR intracoronary stenting and antithrombotic regimen
ISAR-STEREO intracoronary stenting and angiographic results - strut thickness effect on restenosis outcome
ISAT international subarachnoid aneurysm trial
ISTICH international surgical trial in intracerebral hemorrhage
ITT intraventricular thrombolysis trial
IVAT intermediate sized vessel atherectomy trial
L-CAD lipid-coronary artery disease [pravastatin]; sponsor, Bristol-Myers Squibb
LACI laser angioplasty for critical ischemia;
LAMP locally advanced multimodality protocol; [3]
LARS laser angioplasty in restenosed stents
LaSRS late steroid rescue study
LATE late assessment of thrombolytic efficacy;
LEADER lower extremity arterial disease event reduction
LIDO levosimendan [Simdax™] infusion versus dobutamine in low output heart failure
LIDS lumbar invertebrae disk study [device trial]
LIFE losartan intervention for endpoint reduction in hypertension
LIMB ultrasound lysing in lower extremities to minimize blood clots; Angiosonics
LIMIT long lesion intracoronary radiation to minimize intimal hyperplasia trial; sponsor: Guidant Corp. [Galileo™ intravascular radiotherapy system]
LIPID long-term intervention with pravastatin in ischemic disease;
LONG WRIST Washington radiation for in-stent restenosis trial for long lesions
Look AHEAD action for health in diabetes [Xenical; long-term study of effects of weight loss in type 2 diabetics]
L-TAP lipid treatment assessment project
LV3P-CHF left ventricular pacing in pacemaker patients with congestive heart failure (CHF); sponsored by St. Jude Medical
MADIT multicenter automatic defibrillator implantation trial
MAGIC magnesium in coronay arteries
MARISA monotherapy assessment of ranolazine in stable angina;
MARRVEL magnetic resonance radionuclide ventriculography and echocardiography in left ventricular function
MARVAL microalbuminuria reduction with valsartan [Diovan®]
MASH magnesium and acetylsalicylic acid in subarachnoid hemorrhage
MATCH management of atherothrombosis with clopidogrel [Plavix™] in high-risk patients with recent transient ischemic attack or ischemic stroke
MDC metoprolol in dilated cardiomyopathy
MDPIT multicenter diltiazem post infarction trial
MEDENOX prophylaxis in medical patients with enoxaparin [Lovenox®]
MERIT-HF metoprolol CR/XL (controlled release) randomized intervention trial in heart failure;
MIAMI Multi-Link® Duet™ coronary stent in acute myocardial infarction
MICRO-HOPE microalbuminuria, cardiovascular, and renal outcomes (HOPE [heart outcomes prevention evaluation] substudy)
MIRA minocycline in rheumatoid arthritis
MIRACL myocardial ischemia reduction with aggressive cholesterol lowering
MIRACLE multicenter InSync™ randomized clinical evaluation (North America)
MIRACLE ICD multicenter InSync™ randomized clinical evaluation implantable cardioverter defibrillator
MIRAGE multi-institutional research in Alzheimer genetic epidemiology
MMAIT malignant melanoma active immunotherapy trials; [Canvaxin™]
MMSS MyoVive™ marketing surveillance study;
MOBILE more patency with beta for in-stent restenosis in the lower extremity; sponsor: Novoste Corporation [Corona™ system]
MOCHA multicenter oral carvedilol [Coreg®] heart failure assessment
MONICA monitoring trends and determinants in cardiovascular disease
MORE multiple outcomes of raloxifene evaluation
MOST mode selection trial in sinus node dysfunction
MOXCON moxonidine congestive heart failure trial;
MRFIT multiple risk factor intervention trial
MR IMAGES magnetic resonance in intravenous magnesium efficacy in stroke
MSMI multicenter study of myocardial ischemia
MUST medication use studies;
multicenter stent study;
multicenter stents ticlopidine;
MUST EECP multicenter study of enhanced external counterpulsation [EECP®]
MUSTIC multisite stimulation in cardiomyopathy
MUSTT multicenter unstable tachycardia trial;
multicenter unsustained tachycardia trial;
NAFT North American Fragmin® trial
NASCET North American symptomatic carotid endarterectomy trial;
NAVIGATOR nateglinide and valsartan in impaired glucose tolerance outcomes research;
NETT national emphysema treatment trial
NETWORK Network of general practitioners and hospital physicians involved in the study of low versus high doses of enalapril in patients with heart failure trial
NICE Novacor® inflow conduit evaluation; sponsor: World Heart Corporation
NICE 3 national investigators collaborating on enoxaparin [Lovenox®]
NOCIS new onset Crohn's intervention study
OASIS / OASIS-2 organization to assess strategies for ischemic syndromes
OAT open artery trial
OBJECT overactive bladder: judging effective control and treatment [Ditropan XL v. Detrol]
OCBAS optimal coronary balloon angioplasty versus stent
OCTAVE omapatrilat [Vanlev™] cardiovascular treatment assessment versus enalapril
OHTS ocular hypertension treatment study
OMNIUM omeprazole [Prilosec®] versus misoprostol [Cytotec®] for NSAID-induced ulcer management
ONTARGET ongoing telmisartan [Micardis®] alone and in combination with ramipril [Altace®] global endpoint trial
OPERA omapatrilat [Vanlev™] in persons with enhanced risk of atherosclerotic events;
OPTIC optimal pharmacological therapy in implantable cardioverter defibrillator patients; sponsor: St. Jude Medical
OPTIMAAL optimal trial in myocardial infarction with the angiotensin II antagonist losartan
OPTIME-CHF outcomes of a prospective trial of intravenous milrinone for exacerbations of chronic heart failure
OPUS orbofiban in patients with unstable coronary syndromes
ORBIT oral glycoprotein IIb/IIIa receptor blockade to inhibit thrombosis;
OVERTURE omapatrilat versus enalapril randomized trial of utility in reducing events;
PAC-A-TACH pacing in atrial fibrillation and tachycardia
PACIFIC potential angina class improvement for intramyocardial channels
PACT Philadelphia Association of Clinical Trials study
plasminogen activator angioplasty compatibility trial
prehospital application of coronary thrombolysis
prourokinase in acute coronary thrombosis
PAMI primary angioplasty in acute myocardial infarction;
PARADIGM pramlintide for amylin replacement adjunct for diabetes in glycemic management;
PARAGON platelet IIb/IIIa antagonism for the reduction of acute coronary syndrome events in the global organization network
PARIS peripheral artery radiation investigational study [study of the Nucletron® Paris® leg artery radiation catheter]
PASS II piracetam acute stroke study II search help: piracetam
PATH-CHF pacing therapies for congestive heart failure
PAVE post AV node ablation evaluation; sponsored by St. Jude Medical
PCDD prevention of cardiovascular disease in diabetes
PCI-CURE clopidogrel [Plavix®] in unstable angina to prevent recurrent ischemic events in patients undergoing percutaneous coronary intervention; companion to CURE study
PCPT prostate cancer prevention trial; information
PDQUALIF Parkinson('s) disease quality of life
PEACE prevention of events with angiotensin converting enzyme [ACE] inhibitor therapy
PEECH™ prospective evaluation of EECP® in congestive heart failure; sponsor, Vasomedical, Inc.
PENTALYSE synthetic pentasaccharide as an adjunct to fibrinolysis in ST-elevation acute myocardial infarction
PENTUA pentasaccharide in unstable angina
PEPI postmenopausal estrogen/progestin interventions study
PETHEMA programa para el estudio y tratamiento de las hemopatías malignas
[program for the study and treatment of malignant hemopathies]
PHADE pneumatic HeartMate® assist as destination evaluation;
PHAROS pilot Huntington at risk observational study
PIE protease inhibitor experienced [study of Fortovase™ with Kaletra™]
PIVOT prostate cancer intervention versus observation trial
PLESS Proscar® long-term efficacy and safety study;
PLUS propentofylline long-term use study
POEM patency, outcomes and economics of MIDCAB;
POLAR pilot study of low-temperature angiogenic revascularization; sponsor: CryoCath Technologies, Inc.
POST posterior stroke trial
potassium-channel opening stroke trial
POWER PTH for osteoporotic women on estrogen replacement [ALX1-11, a recombinant parathyroid hormone (PTH) formulation]; sponsor: NPS Pharmaceuticals
PRAGUE primary angioplasty in patients transferred from general community hospitals to specialized PTCA units with or without emergency thrombolysis
PRAISE prospective randomized amlodipine survival evaluation
PRECEDENT prospective randomized ectopy evaluation on dobutamine or Natrecor® (nesiritide) therapy; Scios Inc.
PREDICT-HD neurobiologic predictors of Huntington disease onset
PREFER preference study of Gengraf™ compared to Neoral™ in stable solid organ transplant subjects
PREPARE prevent postmenopausal Alzheimer’s with replacement estrogens (a.k.a. Alzheimer('s) disease prevention trial)
PRESENT preliminary safety evaluation of nanoporous tacrolimus-eluting stents; sponsor: JOMED N.V.
PRESTO Parkinson('s) rasagiline: efficacy & safety in the treatment of "OFF"
prevention of restenosis with tranilast and its outcomes
PREVENT prevention of recurrent venous thromboembolism
program in ex vivo vein graft engineering via transfection
proliferation reduction with vascular energy trial; sponsor: Guidant Corp.
prospective randomized evaluation of the vascular effects of Norvasc® trial
PRIDE protection during saphenous vein graft intervention to prevent distal embolization);
PRIME pramipexole in minority persons with Parkinson('s) disease: efficacy
program for irbesartan mortality and morbidity evaluations [consists of two studies: IRMA 2 and IDNT]
PRIMO-CABG pexelizumab for reduction in infarction and mortality in coronary artery bypass graft surgery
PRINCE pravastatin inflammation/CRP evaluation
PRINCESS prevention of reinfarction with early treatment by cerivastatin study
PRISM-PLUS platelet receptor inhibition for ischemic syndrome management in patients limited to very unstable signs and symptoms;
PROACT prolyse in acute cerebral thromboembolism
PROACTION prospective randomized outcomes study of acutely decompensated congestive heart failure treated initially in outpatients with Natrecor®;
PROBE Primacor (milrinone lactate) for optimization of beta-blocker efficacy
PROBE evaluation prospective, randomized, open, blinded endpoint;
PROBIT promotion of breastfeeding intervention trial
PROGENI Parkinson('s) research: the organized genetics initiative
PROGRESS perindopril [Aceon®] protection against recurrent stroke study
PROMPT profiling Remicade onset with methotrexate in a prospective trial
PROSPER prospective study of pravastatin in the elderly at risk
PROTEKT prospective resistant organism tracking for the ketolide telithromycin [Ketek™]
PROVE IT pravastatin or atorvastatin evaluation and infection therapy;
PROWESS recombinant human activated protein C [Xigris™] worldwide evaluation in severe sepsis
PSYCLOPS psychosis and clozapine in Parkinson's disease
PTAMD prophylactic treatment of AMD [age-related macular degeneration]
PURSUIT platelet glycoprotein IIb/IIIa in unstable angina: receptor suppression using Integrilin™ therapy
QoLITY quality of life trial hypertension;
QUIET quinapril [Accupril™] ischemic event trial
RACECAR restenosis and clinical evaluation in coronary arteries; sponsor: Medtronic
RALES randomized Aldactone® (spironolactone) evaluation study for congestive heart failure;
RAPID radiation after PTA is done; sponsor: Radiance Medical Systems [RDX™ coronary radiation delivery catheter]
rapid-acting Parkinson('s) drug
RAPPORT ReoPro® and primary PTCA organization and ramdomized trial
RAVEL randomized study with the sirolimus-eluting Bx Velocity™ balloon-expandable stent [Cypher™]; sponsor: Cordis
REACH rehabilitation among women with coronary heart disease
research on endothelin antagonism in chronic heart failure;
REACT rapid early action for coronary treatment; University of Minnesota and JAMA 2000;283:3223-3229 [July 5, 2000]
ReALIZe research to assess the long-term impact of Zomaril™
RECIFE reduction of cholesterol in ischemia and function of the endothelium
REDHOT rapid emergency department heart failure outpatient trial
[Trial to evaluate clinical utility of the Triage® BNP test in assessing effectiveness of therapy in the management of CHF.]
REGRESS regression growth evaluation statin study
REIN ramipril efficacy in nephropathy
REMATCH randomized evaluation of mechanical assistance therapy as an alternative in congestive heart failure;
RENAAL reduction in endpoints in patients with non–insulin-dependent diabetes mellitus with the angiotensin II antagonist losartan
RENAISSANCE randomized Enbrel® North American strategy to study antagonism of cytokines
RESPECT risk evaluation and stroke prevention in the elderly - cerivastatin trial;
RESTOR R stent™ efficacy and safety trial Orbus; sponsor: Orbus Medical Technologies
RESTORE randomized efficacy study of tirofiban for outcomes and restenosis;
REVERSAL reversal of atherosclerosis with Lipitor™
REVERT reversal of ventricular remodeling with Toprol-XL®;
RHYTHM resynchronization for hemodynamic treatment for heart failure management; sponsor: St. Jude Medical [Epic™ HF ]
RID-HD riluzole dosing in Huntington disease
RITZ-2 randomized intravenous tezosentan
ROSTER rotational atherectomy versus balloon angioplasty for diffuse in-stent restenosis
RUTH raloxifene use for the heart;
SADHAT sertraline (Zoloft®) antidepressant heart attack trial
SADHART sertraline antidepressant heart attack randomized trial
SAFE safety after fifty evaluation
SAFER saphenous vein graft angioplasty free of emboli randomized trial; entry
SAFE-T sotalol and amiodarone atrial fibrillation effectiveness trial
SAGE study assessing goals in the elderly
SAPPHIRE systolic and pulse pressure hemodynamic improvement by restoring elasticity; sponsor: Alteon Inc. [ALT-711]
SARECCO stent or angioplasty after recanalization of chronic coronary occlusions
S.A.V.S. Synercid® as an alternative to vancomycin in staph[ylococcal infections] SAVS
SCD-HeFT or SCDHeFT sudden cardiac death/heart failure trial
SCRIP study of cardiovascular risk intervention by pharmacists
SCRIPPS Scripps coronary radiation to inhibit proliferation post stenting
SEAL simple and effective arterial closure study;
SEARCH study of effectiveness of additional reductions of cholesterol and homocysteine
SECURE study to evaluate carotid ultrasound changes in patients treated with ramipril [Altace®] and vitamin E
SELECT selenium and vitamin E cancer prevention trial; description
SELENA safety of estrogens in lupus erythematosus national assessment
SHARP subcutaneous heparin and angioplasty restenosis prevention
SHELTER stenting of high risk patients extracranial lesions trial with emboli removal;
SHEP systolic hypertension in the elderly program
SHIPS study of a home intervention post stroke
SHOCK should we emergently revascularize occluded coronaries for cardiogenic shock
SHOW study of health outcomes in weight loss
SICCO stenting in chronic coronary occlusion
SIESTA snooze-induced excitation of sympathetic triggered activity
SILCAAT study of interleukin-2 (IL-2) in people with low CD4+ T-cell counts on active anti-HIV therapy; Chiron Corporation
SILENT sonotherapy for in-lesion elimination of neointimal tissue; sponsor: PharmaSonics Inc.; also see
SILVER systolic hypertension interaction with left ventricular remodeling; sponsor: Alteon Inc. [ALT-711]
SIRIUS a multicenter randomized double-blind study of the sirolimus-coated Bx Velocity™ stent [referred to as Cypher™ sirolimus-eluting stent] in the treatment of patients with de novo coronary artery lesions; sponsor: Cordis search help: s/l "serious"
SIROCCO sirolimus-coated Cordis S.M.A.R.T™ nitinol self-expanding stent in the treatment of obstructive superficial femoral artery disease
SMART second manifestations of arterial disease
serum markers acute myocardial infarction and rapid treatment
strategies for the management of antiretroviral therapy
study of medicine versus angioplasty reperfusion trial
study of Microstent's ability to limit restenosis trial
study of monoclonal antibody radioimmunotherapy;
Synercid® microbiological assessment of resistance trends;
SMILE survival of myocardial infarction long-term evaluation
SNAP study of nitroglycerin and chest pain
SPAF stroke prevention in atrial fibrillation
SPEED strategies for patency enhancement in the emergency department
SPORT spine patient ooutcomes research trial
stent implantation post rotational atherectomy trial
SPORTIF-V stroke prevention using oral thrombin inhibition in atrial fibrillation - V [5th series of SPORTIF trials];
SOLVD studies of left ventricular dysfunction
SONIA stroke outcomes and neuroimaging of intracranial atherosclerosis
SONORA safety of Neoral outcomes in rheumatoid arthritis
S.O.N.O.R.A.SM study of new onset rheumatoid arthritis; sponsor: Knoll Pharmaceutical Company
SoS stent or surgery
SPARCL stroke prevention by aggressive reduction in cholesterol levels
SPICE study of protease inhibitor combination in Europe;
SPLASH sonotherapy prevention of late arterial in-stent hyperplasia; sponsor: PharmaSonics, Inc.; also see
SPS3 stroke prevention of small subcortical strokes
SSITT Swiss-Spanish intermittent trial
SSYLVIA stenting in symptomatic atherosclerotic lesions of vertebral and intracranial arteries
STAR study of tamoxifen and raloxifene;
STARS standard treatment with activase to reverse stroke
START saruplase and taprostene acute reocclusion trial
St. Thomas' atherosclerosis regression trial
study of thrombolytic therapy with additional response following taprostene
stent versus angioplasty restenosis trial
stent versus directional coronary atherectomy randomized trial
stents and radiation therapy;
selection of thymidine analog regimen therapy;
STAT stroke treatment with ancrod trial
Stent PAMI stent primary angioplasty for myocardial infarction
STEP-BD systematic treatment enhancement program for bipolar disorder; study description
STICH surgical treatment for intracerebral hemorrhage
STOP sonotherapy for the treatment of peripheral vascular disease; sponsor: PharmaSonics, Inc.
STOP-DUB surgical treatments outcomes project for dysfunctional uterine bleeding
STOP-Hypertension Swedish trial in old patients with hypertension;
STRATAS study to determine Rotablator® and transluminal angioplasty strategy
STRENGTH
STRENGTH II
statin response examined by genetic HAP™ markers; sponsor: Genaissance Pharmaceuticals
STRESS stent restenosis study
STRETCH symptom, tolerability, response to exercise trial of candesartan cilexetil [Atacand™] in heart failure
STRIDE sitaxsentan to relieve impaired exercise in pulmonary hypertension
SUDEP sudden unexpected death in epilepsy
SWEDIC Sweden diastolic carvedilol
SWIFT should we intervene following thrombolysis
SWING sound waves inhibit neointimal growth; sponsor: PharmaSonics Inc.; also see
SWISS siblings with ischemic stroke study
SWOG Southwest Oncology Group [an adult cancer clinical trials organization]; SWOG protocols by indication
SYMPHONY sibrafiban versus aspirin to yield maximum protection from ischemic heart events post-acute coronary syndromes;
SYNERGY superior yield of the new strategy of enoxaparin, revascularization, and glycoprotein IIb/IIIa inhibitors
TACT trial to assess chelation therapy [EDTA chelation therapy for coronary artery disease]; sponsor: National Institutes of Health (NIH)
TACTICS thrombolysis and counterpulsation to improve cardiogenic shock survival
treat angina with Aggrastat® and determine costs of therapy with invasive or conservative strategies [TIMI-18]
TAIST tinzaparin in acute ischemic stroke trial
TARGET do tirofiban [Aggrastat®] and ReoPro give similar efficacy outcomes trial
TCAS temperature control during aneurysm surgery
TexCAPS Texas coronary atherosclerosis prevention study
TeqCES Tequin® clinical experience study
TheraP TheraSource™ Pd-103 for prevention of restenosis; sponsor: Theragenics Corporation [TheraSource™ intravascular brachytherapy system]
TIGER-PA tirofiban given in the emergency room before primary angioplasty
TIME trial of invasive vs. medical therapy in elderly patients with chronic CAD
TIMI thrombolysis in myocardial infarction;
thrombin inhibition in myocardial infarction
TNT treating to new targets
TOAT the open artery trial
TONE trial of nonpharmacologic interventions in the elderly
TOP treatment of osteoporosis with PTH [ALX1-11, a recombinant parathyroid hormone (PTH) formulation]; sponsor: NPS Pharmaceuticals
TOPIC tobramycin once-daily prescribing in cystic fibrosis
TRACE trandolapril cardiac evaluation study
trial of genetic assessment in breast cancer
TRAFFIC therapeutic angiogenesis with FGF-2 (fibroblast growth factor) for intermittent claudication; sponsor: Chiron Corporation
TRANSCEND telmisartan [Micardis®] randomized assessment study in ace intolerant subjects with cardiovascular disease
TREAT tranilast restenosis following angioplasty trial
TREND trial on reversing endothelial dysfunction
TROPHY trial for preventing hypertension;
TRUST Tenax® for the prevention of restenosis and acute thrombotic complications. A useful stent trial [Tenax-XR, a silicon carbide-coated stent]; sponsor: Biotronik, Inc.
TTT4CNV transpupillary thermotherapy for choroidal neovascularization
TURBO the ultrasound removal of blood clots in vein grafts; Angiosonics
TUSS tuberculosis ultraviolet shelter study
UK-HEART United Kingdom heart failure evaluation and assessment of risk trial
UKPDS United Kingdom perspective diabetes study
UNAIDS PETRA United Nations programme on HIV/AIDS perinatal transmission trial
VA-HIT Veterans Administration HDL intervention trial
Val-HeFT valsartan heart failure trial;
VALIANT valsartan in acute myocardial infarction trial;
Vascular Architects femoropopliteal suboptimal angioplasty aSpire™ stent trial; sponsor: Vascular Architects
VALUE valsartan antihypertensive long-term use evaluation;
VANILA ventricular arrhythmia needing intravenous lidocaine/amiodarone
VANQWISH Veterans Affairs non–Q-wave infarction strategies in hospital
VERT vertebral efficacy with risedronate therapy; risedronate (Actonel®)
VICTORY elective and acute stenting of coronary arteries on Express™ [coronary stent system]; sponsor: Boston Scientific
VIGOR Vioxx® gastrointestinal outcomes research
VINTAGE MI vascular interaction with age in myocardial infarction
VISION vascular intervention study with ionizing radiation; sponsor: Guidant Corp. [Galileo™ intravascular radiotherapy system]
VISP vitamin intervention for stroke prevention
VITATOPS vitamins to prevent stroke
VIVA VEGF (vascular endothelial growth factor) in ischemia for vascular angiogenesis
VMAC vasodilation in the management of acute congestive heart failure;
WARCEF warfarin-aspirin reduced cardiac ejection fraction
WARIS-II warfarin-aspirin reinfarction study
WARSS warfarin aspirin recurrent stroke study
WASID warfarin-asprin symptomatic intracranial disease study
WATCH warfarin & antiplatelet therapy in chronic CHF
women atorvastatin trial on cholesterol
WAVE women's angiographic vitamins and estrogen trial
WEARIT wearable cardioverter-defibrillator investigational trial
WIHS women's interagency HIV study
WINS women’s intervention nutrition study
WISE women's ischemia syndrome evaluation;
WIZARD weekly intervention with Zithromax® against atherosclerosis and related disorders
Women's HOPE Women's health, osteoporosis, progestin, and estrogen study
WRIST Washington radiation for in-stent restenosis trial
XISHF xamoterol in severe heart failure
X-TRACT X-Sizer™ for treatment of thrombus and atherosclerosis in coronary interventions trial X-Sizer
ZEUS Zomaril™ efficacy/utility and safety;
ZIPP Zoladex® (goserelin acetate implant) in premenopausal patients

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