Acitretin

Acitretin

File:Acitretin.svg
Clinical data
ATC code	D05BB02 (WHO)
Identifiers
IUPAC name 9-(4-methoxy-2,3, 6-trimethyl-phenyl)- 3,7-dimethyl-nona-2,4,6,8- tetraenoic acid
CAS Number	55079-83-9
PubChem CID	6437841
DrugBank	APRD00778
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C21H26O3
Molar mass	326.429 g/mol

Acitretin (trade name Soriatane®) is a second generation retinoid. It is taken orally, and is typically used for psoriasis.

It is a metabolite of etretinate, which was used prior to the introduction of acitretin. Etretinate was discontinued because it had a narrow therapeutic index as well as a long elimination half-life (t_1/2=120 days), making dosing difficult. In contrast, acitretin's half-life is approximately 2 days.

Women must avoid becoming pregnant for at least 3 years after discontinuing acitretin. In comparison, etretinate was not recommended at all for women who planned to become pregnant.

Pill Images

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 |Drug Author=Stiefel Laboratories Inc
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