Acinic cell carcinoma historical perspective

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Historical Perspective

Swathi Venkatesan, M.B.B.S.[1]

  • ACC was referred to as an entity for the first time more than 50 years ago by Godwin et al
  • The “acinar” term is derived from Latin term “acinus”, which means a cluster of and looks like grapes branch
  • The histological appearance is quite similar to secretory parenchymatous cells.
  • Before discovering this disease, clinically Acinic Cell Carcinoma was unrecognized.
  • At the time after recognizing the disease, it thought to be the nature of the tumor is benign.
  • Afterward, it has been detected that the recurrence tendency of the tumor showed the possibility of the malignant nature of the tumor.
  • Later WHO (World Health Organization) re-classified as a “malignant carcinoma” with low-grade behavior.
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