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===Differentiating acinic cell carcinoma from other diseases on the basis of histology findings===
===Differentiating acinic cell carcinoma from other diseases on the basis of histology findings===


On the basis of histologic findings acinic cell carcinoma must be differentiated from other salivary and head and neck masses such as slivary metastasis of of thyroid carcinoma, salivary oncocytoma, mucoepidermoid carcinoma, inconspicuous mucous/squamoid cells, mammary analogue secretory carcinoma.
On the basis of histologic findings acinic cell carcinoma must be differentiated from other salivary and head and neck masses such as salivary metastasis of thyroid carcinoma, salivary oncocytoma, mucoepidermoid carcinoma, inconspicuous mucous/squamoid cells, Mammary analog secretory carcinoma.
{|
 
|- style="background: #4479BA; color: #FFFFFF; text-align: center;"
{| class="wikitable"
! rowspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Diseases
|+
! colspan="2" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Para-clinical findings
!
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Over lapping features
! colspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Histological findings
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Distinguishing features
|-
|-
| style="background: #DCDCDC; padding: 5px; text-align: center;" |slivary metastasis of of thyroid carcinoma
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Diseases
| style="background: #4479BA; color: #FFFFFF; text-align: center;" |Overlapping features
| style="background: #4479BA; color: #FFFFFF; text-align: center;" |Distinguishing features
|-
| style="background: #DCDCDC; padding: 5px; text-align: center;" |Salivary metastasis of thyroid carcinoma
| style="background: #F5F5F5; padding: 5px;" |Empty appearance, grooves, pseudoinclusions
| style="background: #F5F5F5; padding: 5px;" |Empty appearance, grooves, pseudoinclusions
| style="background: #F5F5F5; padding: 5px;" |Immunohistochemistry (tyrogloubin)
| style="background: #F5F5F5; padding: 5px;" |Immunohistochemistry (Tyrogloubin)
|-
|-
| style="background: #DCDCDC; padding: 5px; text-align: center;" |salivary oncocytoma
| style="background: #DCDCDC; padding: 5px; text-align: center;" |salivary oncocytoma
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| style="background: #F5F5F5; padding: 5px;" |Immunohistochemistry for p63
| style="background: #F5F5F5; padding: 5px;" |Immunohistochemistry for p63
|-
|-
| style="background: #DCDCDC; padding: 5px; text-align: center;" |mammary analogue secretory carcinoma
| style="background: #DCDCDC; padding: 5px; text-align: center;" |Mammary analoge secretory carcinoma
| style="background: #F5F5F5; padding: 5px;" |Histologically similar
| style="background: #F5F5F5; padding: 5px;" |Histologically similar
| style="background: #F5F5F5; padding: 5px;" |Lack of PAS-positive secretory granules, vimentin positive, adipophilin positive  
| style="background: #F5F5F5; padding: 5px;" |Lack of PAS-positive secretory granules, Vimentin positive, Adipophilin positive  
|-
|-
|}
|}

Revision as of 13:31, 12 September 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2]

Overview

Differentiating acinic cell carcinoma from other Diseases

Differentiating acinic cell carcinoma from other diseases on the basis of histology findings

On the basis of histologic findings acinic cell carcinoma must be differentiated from other salivary and head and neck masses such as salivary metastasis of thyroid carcinoma, salivary oncocytoma, mucoepidermoid carcinoma, inconspicuous mucous/squamoid cells, Mammary analog secretory carcinoma.

Histological findings
Diseases Overlapping features Distinguishing features
Salivary metastasis of thyroid carcinoma Empty appearance, grooves, pseudoinclusions Immunohistochemistry (Tyrogloubin)
salivary oncocytoma Eosinophilic, non-serous cells Hematoxylin
mucoepidermoid carcinoma Microcystic, and follicula, inconspicuous mucous/squamoid cells, eosinophilic Immunohistochemistry for p63
Mammary analoge secretory carcinoma Histologically similar Lack of PAS-positive secretory granules, Vimentin positive, Adipophilin positive

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