ATP1A4: Difference between revisions
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{{ | '''Sodium/potassium-transporting ATPase subunit alpha-4''' is an [[enzyme]] that in humans is encoded by the ''ATP1A4'' [[gene]].<ref name="pmid1981991">{{cite journal | vauthors = Buetow KH, Nishimura D, Nakamura Y, Jiang O, Murray JC | title = A detailed multipoint gene map of chromosome 1q | journal = Genomics | volume = 8 | issue = 1 | pages = 13–21 |date=May 1991 | pmid = 1981991 | pmc = | doi =10.1016/0888-7543(90)90220-O }}</ref><ref name="pmid3035563">{{cite journal | vauthors = Shull MM, Lingrel JB | title = Multiple genes encode the human Na+,K+-ATPase catalytic subunit | journal = Proc Natl Acad Sci U S A | volume = 84 | issue = 12 | pages = 4039–43 |date=Jul 1987 | pmid = 3035563 | pmc = 305017 | doi =10.1073/pnas.84.12.4039 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=480| accessdate = }}</ref> | ||
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| summary_text = The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref name="entrez" | | summary_text = The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-[[Co-transport|coupled transport]] of a variety of organic and inorganic molecules, and for [[electrical excitability]] of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref name="entrez" /> | ||
}} | }} | ||
==References== | ==References== | ||
{{reflist| | {{reflist}} | ||
==External links== | |||
* {{UCSC gene info|ATP1A1}} | |||
* {{UCSC gene info|ATP1A4}} | |||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal | vauthors=Lingrel JB, Orlowski J, Shull MM, Price EM |title=Molecular genetics of Na, K-ATPase |journal=Prog. Nucleic Acid Res. Mol. Biol. |volume=38 |issue= |pages= 37–89 |year= 1990 |pmid= 2158121 |doi=10.1016/S0079-6603(08)60708-4 | series=Progress in Nucleic Acid Research and Molecular Biology | isbn=978-0-12-540038-1 }} | ||
*{{cite journal | vauthors=Sverdlov ED, Broude NE, Sverdlov VE |title=Family of Na+,K+-ATPase genes. Intra-individual tissue-specific restriction fragment length polymorphism |journal=FEBS Lett. |volume=221 |issue= 1 |pages= 129–33 |year= 1987 |pmid= 2887455 |doi=10.1016/0014-5793(87)80366-6 |display-authors=etal}} | |||
*{{cite journal | | *{{cite journal | vauthors=Sverdlov ED, Monastyrskaya GS, Broude NE |title=The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit |journal=FEBS Lett. |volume=217 |issue= 2 |pages= 275–8 |year= 1987 |pmid= 3036582 |doi=10.1016/0014-5793(87)80677-4 |display-authors=etal}} | ||
*{{cite journal | vauthors=Shamraj OI, Lingrel JB |title=A putative fourth Na+,K(+)-ATPase alpha-subunit gene is expressed in testis |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 26 |pages= 12952–6 |year= 1995 |pmid= 7809153 |doi=10.1073/pnas.91.26.12952 | pmc=45558 }} | |||
*{{cite journal | | *{{cite journal | vauthors=Woo AL, James PF, Lingrel JB |title=Characterization of the fourth alpha isoform of the Na, K-ATPase |journal=J. Membr. Biol. |volume=169 |issue= 1 |pages= 39–44 |year= 1999 |pmid= 10227850 |doi=10.1007/PL00005899 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Woo AL, James PF, Lingrel JB |title=Sperm motility is dependent on a unique isoform of the Na, K-ATPase |journal=J. Biol. Chem. |volume=275 |issue= 27 |pages= 20693–9 |year= 2000 |pmid= 10764792 |doi= 10.1074/jbc.M002323200 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Woo AL, James PF, Lingrel JB |title=Roles of the Na, K-ATPase alpha4 isoform and the Na+/H+ exchanger in sperm motility |journal=Mol. Reprod. Dev. |volume=62 |issue= 3 |pages= 348–56 |year= 2003 |pmid= 12112599 |doi= 10.1002/mrd.90002 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Keryanov S, Gardner KL |title=Physical mapping and characterization of the human Na, K-ATPase isoform, ATP1A4 |journal=Gene |volume=292 |issue= 1–2 |pages= 151–66 |year= 2002 |pmid= 12119109 |doi=10.1016/S0378-1119(02)00647-9 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Lingrel J, Moseley A, Dostanic I |title=Functional roles of the alpha isoforms of the Na, K-ATPase |journal=Ann. N. Y. Acad. Sci. |volume=986 |issue= |pages= 354–9 |year= 2003 |pmid= 12763850 |doi=10.1111/j.1749-6632.2003.tb07214.x |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Hlivko JT, Chakraborty S, Hlivko TJ |title=The human Na, K-ATPase alpha 4 isoform is an ouabain-sensitive alpha isoform that is expressed in sperm |journal=Mol. Reprod. Dev. |volume=73 |issue= 1 |pages= 101–15 |year= 2006 |pmid= 16175638 |doi= 10.1002/mrd.20383 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Gregory SG, Barlow KF, McLay KE |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Rodova M, Nguyen AN, Blanco G |title=The transcription factor CREMtau and cAMP regulate promoter activity of the Na, K-ATPase alpha4 isoform |journal=Mol. Reprod. Dev. |volume=73 |issue= 11 |pages= 1435–47 |year= 2006 |pmid= 16894555 |doi= 10.1002/mrd.20518 }} | ||
*{{cite journal | | |||
*{{cite journal | | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
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External IDs | GeneCards: [1] | ||||||
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Species | Human | Mouse | |||||
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Location (UCSC) | n/a | n/a | |||||
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Sodium/potassium-transporting ATPase subunit alpha-4 is an enzyme that in humans is encoded by the ATP1A4 gene.[1][2][3]
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.[3]
References
- ↑ Buetow KH, Nishimura D, Nakamura Y, Jiang O, Murray JC (May 1991). "A detailed multipoint gene map of chromosome 1q". Genomics. 8 (1): 13–21. doi:10.1016/0888-7543(90)90220-O. PMID 1981991.
- ↑ Shull MM, Lingrel JB (Jul 1987). "Multiple genes encode the human Na+,K+-ATPase catalytic subunit". Proc Natl Acad Sci U S A. 84 (12): 4039–43. doi:10.1073/pnas.84.12.4039. PMC 305017. PMID 3035563.
- ↑ 3.0 3.1 "Entrez Gene: ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide".
External links
- Human ATP1A1 genome location and ATP1A1 gene details page in the UCSC Genome Browser.
- Human ATP1A4 genome location and ATP1A4 gene details page in the UCSC Genome Browser.
Further reading
- Lingrel JB, Orlowski J, Shull MM, Price EM (1990). "Molecular genetics of Na, K-ATPase". Prog. Nucleic Acid Res. Mol. Biol. Progress in Nucleic Acid Research and Molecular Biology. 38: 37–89. doi:10.1016/S0079-6603(08)60708-4. ISBN 978-0-12-540038-1. PMID 2158121.
- Sverdlov ED, Broude NE, Sverdlov VE, et al. (1987). "Family of Na+,K+-ATPase genes. Intra-individual tissue-specific restriction fragment length polymorphism". FEBS Lett. 221 (1): 129–33. doi:10.1016/0014-5793(87)80366-6. PMID 2887455.
- Sverdlov ED, Monastyrskaya GS, Broude NE, et al. (1987). "The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit". FEBS Lett. 217 (2): 275–8. doi:10.1016/0014-5793(87)80677-4. PMID 3036582.
- Shamraj OI, Lingrel JB (1995). "A putative fourth Na+,K(+)-ATPase alpha-subunit gene is expressed in testis". Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12952–6. doi:10.1073/pnas.91.26.12952. PMC 45558. PMID 7809153.
- Woo AL, James PF, Lingrel JB (1999). "Characterization of the fourth alpha isoform of the Na, K-ATPase". J. Membr. Biol. 169 (1): 39–44. doi:10.1007/PL00005899. PMID 10227850.
- Woo AL, James PF, Lingrel JB (2000). "Sperm motility is dependent on a unique isoform of the Na, K-ATPase". J. Biol. Chem. 275 (27): 20693–9. doi:10.1074/jbc.M002323200. PMID 10764792.
- Woo AL, James PF, Lingrel JB (2003). "Roles of the Na, K-ATPase alpha4 isoform and the Na+/H+ exchanger in sperm motility". Mol. Reprod. Dev. 62 (3): 348–56. doi:10.1002/mrd.90002. PMID 12112599.
- Keryanov S, Gardner KL (2002). "Physical mapping and characterization of the human Na, K-ATPase isoform, ATP1A4". Gene. 292 (1–2): 151–66. doi:10.1016/S0378-1119(02)00647-9. PMID 12119109.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Lingrel J, Moseley A, Dostanic I, et al. (2003). "Functional roles of the alpha isoforms of the Na, K-ATPase". Ann. N. Y. Acad. Sci. 986: 354–9. doi:10.1111/j.1749-6632.2003.tb07214.x. PMID 12763850.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Hlivko JT, Chakraborty S, Hlivko TJ, et al. (2006). "The human Na, K-ATPase alpha 4 isoform is an ouabain-sensitive alpha isoform that is expressed in sperm". Mol. Reprod. Dev. 73 (1): 101–15. doi:10.1002/mrd.20383. PMID 16175638.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
- Rodova M, Nguyen AN, Blanco G (2006). "The transcription factor CREMtau and cAMP regulate promoter activity of the Na, K-ATPase alpha4 isoform". Mol. Reprod. Dev. 73 (11): 1435–47. doi:10.1002/mrd.20518. PMID 16894555.
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