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Revision as of 14:02, 4 September 2012


N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2
Identifiers
Symbols ASAH2 ; HNAC1; MGC129777
External IDs Template:MGI HomoloGene10310
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2, also known as ASAH2, is a human gene.[1]


References

  1. "Entrez Gene: ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2".

Further reading

  • Matoba R, Okubo K, Hori N; et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene. 146 (2): 199–207. PMID 8076819.
  • Tani M, Okino N, Mori K; et al. (2000). "Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. A novel but highly conserved gene family of neutral/alkaline ceramidases". J. Biol. Chem. 275 (15): 11229–34. PMID 10753931.
  • El Bawab S, Roddy P, Qian T; et al. (2000). "Molecular cloning and characterization of a human mitochondrial ceramidase". J. Biol. Chem. 275 (28): 21508–13. doi:10.1074/jbc.M002522200. PMID 10781606.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Choi MS, Anderson MA, Zhang Z; et al. (2004). "Neutral ceramidase gene: role in regulating ceramide-induced apoptosis". Gene. 315: 113–22. PMID 14557071.
  • Deloukas P, Earthrowl ME, Grafham DV; et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
  • Monick MM, Mallampalli RK, Bradford M; et al. (2004). "Cooperative prosurvival activity by ERK and Akt in human alveolar macrophages is dependent on high levels of acid ceramidase activity". J. Immunol. 173 (1): 123–35. PMID 15210766.
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
  • Hwang YH, Tani M, Nakagawa T; et al. (2005). "Subcellular localization of human neutral ceramidase expressed in HEK293 cells". Biochem. Biophys. Res. Commun. 331 (1): 37–42. doi:10.1016/j.bbrc.2005.03.134. PMID 15845354.
  • Osawa Y, Uchinami H, Bielawski J; et al. (2005). "Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha". J. Biol. Chem. 280 (30): 27879–87. doi:10.1074/jbc.M503002200. PMID 15946935.
  • Tani M, Sano T, Ito M, Igarashi Y (2006). "Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets". J. Lipid Res. 46 (11): 2458–67. doi:10.1194/jlr.M500268-JLR200. PMID 16061940.
  • Galadari S, Wu BX, Mao C; et al. (2006). "Identification of a novel amidase motif in neutral ceramidase". Biochem. J. 393 (Pt 3): 687–95. doi:10.1042/BJ20050682. PMID 16229686.
  • Xu R, Jin J, Hu W; et al. (2006). "Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P". FASEB J. 20 (11): 1813–25. doi:10.1096/fj.05-5689com. PMID 16940153.
  • Avramopoulos D, Wang R, Valle D; et al. "A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease". Neurogenetics. 8 (2): 111–20. doi:10.1007/s10048-007-0081-5. PMID 17334805.
  • Ohlsson L, Palmberg C, Duan RD; et al. (2007). "Purification and characterization of human intestinal neutral ceramidase". Biochimie. 89 (8): 950–60. doi:10.1016/j.biochi.2007.03.009. PMID 17475390.

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