ART4

ADP-ribosyltransferase 4 (Dombrock blood group)
Identifiers
Symbols	ART4 ; CD297; DO; DOK1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 10883
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE ART4 207220 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

WikiDoc Resources for ART4
Articles
Most recent articles on ART4 Most cited articles on ART4 Review articles on ART4 Articles on ART4 in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on ART4 Images of ART4 Photos of ART4 Podcasts & MP3s on ART4 Videos on ART4
Evidence Based Medicine
Cochrane Collaboration on ART4 Bandolier on ART4 TRIP on ART4
Clinical Trials
Ongoing Trials on ART4 at Clinical Trials.gov Trial results on ART4 Clinical Trials on ART4 at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on ART4 NICE Guidance on ART4 NHS PRODIGY Guidance FDA on ART4 CDC on ART4
Books
Books on ART4
News
ART4 in the news Be alerted to news on ART4 News trends on ART4
Commentary
Blogs on ART4
Definitions
Definitions of ART4
Patient Resources / Community
Patient resources on ART4 Discussion groups on ART4 Patient Handouts on ART4 Directions to Hospitals Treating ART4 Risk calculators and risk factors for ART4
Healthcare Provider Resources
Symptoms of ART4 Causes & Risk Factors for ART4 Diagnostic studies for ART4 Treatment of ART4
Continuing Medical Education (CME)
CME Programs on ART4
International
ART4 en Espanol ART4 en Francais
Business
ART4 in the Marketplace Patents on ART4
Experimental / Informatics
List of terms related to ART4

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

ADP-ribosyltransferase 4 (Dombrock blood group), also known as ART4, is a human gene. ART4 has also been designated as CD297 (cluster of differentiation 297).

This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinosotol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known.

Further reading

• Reid ME (2003). "The Dombrock blood group system: a review". Transfusion. 43 (1): 107–14. PMID 12519438.
• Tippett P (1967). "Genetics of the Dombrock blood group system". J. Med. Genet. 4 (1): 7–11. PMID 6034522.
• Eiberg H, Mohr J (1996). "Dombrock blood group (DO): assignment to chromosome 12p". Hum. Genet. 98 (5): 518–21. PMID 8882867.
• Koch-Nolte F, Haag F, Braren R; et al. (1997). "Two novel human members of an emerging mammalian gene family related to mono-ADP-ribosylating bacterial toxins". Genomics. 39 (3): 370–6. doi:10.1006/geno.1996.4520. PMID 9119374.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mauthe J, Coghlan G, Zelinski T (2000). "Confirmation of the assignment of the Dombrock blood group locus (DO) to chromosome 12p: narrowing the boundaries to 12p12.3-p13.2". Vox Sang. 79 (1): 53–6. PMID 10971215.CS1 maint: Multiple names: authors list (link)
• Gubin AN, Njoroge JM, Wojda U; et al. (2000). "Identification of the dombrock blood group glycoprotein as a polymorphic member of the ADP-ribosyltransferase gene family". Blood. 96 (7): 2621–7. PMID 11001920.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wu GG, Jin SZ, Deng ZH, Zhao TM (2002). "Polymerase chain reaction with sequence-specific primers-based genotyping of the human Dombrock blood group DO1 and DO2 alleles and the DO gene frequencies in Chinese blood donors". Vox Sang. 81 (1): 49–51. PMID 11520417.CS1 maint: Multiple names: authors list (link)
• Rios M, Hue-Roye K, Øyen R; et al. (2002). "Insights into the Holley- and Joseph- phenotypes". Transfusion. 42 (1): 52–8. PMID 11896313.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rios M, Storry JR, Hue-Roye K; et al. (2002). "Two new molecular bases for the Dombrock null phenotype". Br. J. Haematol. 117 (3): 765–7. PMID 12028057.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Glowacki G, Braren R, Firner K; et al. (2003). "The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse". Protein Sci. 11 (7): 1657–70. PMID 12070318.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Grahnert A, Friedrich M, Engeland K, Hauschildt S (2005). "Analysis of mono-ADP-ribosyltransferase 4 gene expression in human monocytes: splicing pattern and potential regulatory elements". Biochim. Biophys. Acta. 1730 (3): 173–86. doi:10.1016/j.bbaexp.2005.08.001. PMID 16140404.CS1 maint: Multiple names: authors list (link)

External links

• ART4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.