ARHGEF11

Rho guanine nucleotide exchange factor (GEF) 11
PDB rendering based on 1htj.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1htj​, 1xcg​, 2dls​
Identifiers
Symbols	ARHGEF11 ; DKFZp667F1223; GTRAP48; KIAA0380; PDZ-RHOGEF
External IDs	Template:OMIM5 Template:MGI HomoloGene: 11409
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Rho guanine nucleotide exchange factor (GEF) 11, also known as ARHGEF11, is a human gene.

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described.

Further reading

• Nagase T, Ishikawa K, Nakajima D; et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. PMID 9205841.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fukuhara S, Murga C, Zohar M; et al. (1999). "A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho". J. Biol. Chem. 274 (9): 5868–79. PMID 10026210.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rümenapp U, Blomquist A, Schwörer G; et al. (1999). "Rho-specific binding and guanine nucleotide exchange catalysis by KIAA0380, a dbl family member". FEBS Lett. 459 (3): 313–8. PMID 10526156.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Togashi H, Nagata K, Takagishi M; et al. (2000). "Functions of a rho-specific guanine nucleotide exchange factor in neurite retraction. Possible role of a proline-rich motif of KIAA0380 in localization". J. Biol. Chem. 275 (38): 29570–8. doi:10.1074/jbc.M003726200. PMID 10900204.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jackson M, Song W, Liu MY; et al. (2001). "Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins". Nature. 410 (6824): 89–93. doi:10.1038/35065091. PMID 11242047.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Longenecker KL, Lewis ME, Chikumi H; et al. (2001). "Structure of the RGS-like domain from PDZ-RhoGEF: linking heterotrimeric g protein-coupled signaling to Rho GTPases". Structure. 9 (7): 559–69. PMID 11470431.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Perrot V, Vazquez-Prado J, Gutkind JS (2003). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". J. Biol. Chem. 277 (45): 43115–20. doi:10.1074/jbc.M206005200. PMID 12183458.CS1 maint: Multiple names: authors list (link)
• Driessens MH, Olivo C, Nagata K; et al. (2002). "B plexins activate Rho through PDZ-RhoGEF". FEBS Lett. 529 (2–3): 168–72. PMID 12372594.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMID 12421765.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Barac A, Basile J, Vázquez-Prado J; et al. (2004). "Direct interaction of p21-activated kinase 4 with PDZ-RhoGEF, a G protein-linked Rho guanine exchange factor". J. Biol. Chem. 279 (7): 6182–9. doi:10.1074/jbc.M309579200. PMID 14625312.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Davidkova G, McCullumsmith RE, Meador-Woodruff JH (2004). "Expression of ARHGEF11 mRNA in schizophrenic thalamus". Ann. N. Y. Acad. Sci. 1003: 375–7. PMID 14684465.CS1 maint: Multiple names: authors list (link)
• Banerjee J, Wedegaertner PB (2004). "Identification of a novel sequence in PDZ-RhoGEF that mediates interaction with the actin cytoskeleton". Mol. Biol. Cell. 15 (4): 1760–75. doi:10.1091/mbc.E03-07-0527. PMID 14742719.
• Wang Q, Liu M, Kozasa T; et al. (2004). "Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells". J. Biol. Chem. 279 (28): 28831–4. doi:10.1074/jbc.C400105200. PMID 15143072.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Guo X, Li Y, Peng K; et al. (2006). "Solution structures and backbone dynamics of arsenate reductase from Bacillus subtilis: reversible conformational switch associated with arsenate reduction". J. Biol. Chem. 280 (47): 39601–8. doi:10.1074/jbc.M508132200. PMID 16192272.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Longhurst DM, Watanabe M, Rothstein JD, Jackson M (2006). "Interaction of PDZRhoGEF with microtubule-associated protein 1 light chains: link between microtubules, actin cytoskeleton, and neuronal polarity". J. Biol. Chem. 281 (17): 12030–40. doi:10.1074/jbc.M513756200. PMID 16478718.CS1 maint: Multiple names: authors list (link)
• Gu J, Wu X, Dong Q; et al. (2006). "A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans". Cancer. 106 (12): 2716–24. doi:10.1002/cncr.21944. PMID 16691626.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ma L, Hanson RL, Que LN; et al. (2007). "Variants in ARHGEF11, a candidate gene for the linkage to type 2 diabetes on chromosome 1q, are nominally associated with insulin resistance and type 2 diabetes in Pima Indians". Diabetes. 56 (5): 1454–9. doi:10.2337/db06-0640. PMID 17287471.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)