ARHGEF11: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Rho guanine nucleotide exchange factor 11''' is a [[protein]] that in humans is encoded by the ''ARHGEF11'' [[gene]].<ref name="pmid10526156">{{cite journal | vauthors = Rümenapp U, Blomquist A, Schwörer G, Schablowski H, Psoma A, Jakobs KH | title = Rho-specific binding and guanine nucleotide exchange catalysis by KIAA0380, a dbl family member | journal = FEBS Letters | volume = 459 | issue = 3 | pages = 313–8 | date = Oct 1999 | pmid = 10526156 | pmc =  | doi = 10.1016/S0014-5793(99)01270-3 }}</ref><ref name="pmid9205841">{{cite journal | vauthors = Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Research | volume = 4 | issue = 2 | pages = 141–50 | date = Apr 1997 | pmid = 9205841 | pmc = | doi = 10.1093/dnares/4.2.141 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9826| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_ARHGEF11_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1htj.
| PDB = {{PDB2|1htj}}, {{PDB2|1xcg}}, {{PDB2|2dls}}
| Name = Rho guanine nucleotide exchange factor (GEF) 11
| HGNCid = 14580
| Symbol = ARHGEF11
| AltSymbols =; DKFZp667F1223; GTRAP48; KIAA0380; PDZ-RHOGEF
| OMIM = 605708
| ECnumber = 
| Homologene = 11409
| MGIid = 2441869
| GeneAtlas_image1 = PBB_GE_ARHGEF11_202913_at_tn.png
| GeneAtlas_image2 = PBB_GE_ARHGEF11_202914_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005085 |text = guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0005089 |text = Rho guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0005096 |text = GTPase activator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0000910 |text = cytokinesis}} {{GNF_GO|id=GO:0001558 |text = regulation of cell growth}} {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0006941 |text = striated muscle contraction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0030010 |text = establishment of cell polarity}} {{GNF_GO|id=GO:0030036 |text = actin cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0035023 |text = regulation of Rho protein signal transduction}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9826
    | Hs_Ensembl = ENSG00000132694
    | Hs_RefseqProtein = NP_055599
    | Hs_RefseqmRNA = NM_014784
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 155171256
    | Hs_GenLoc_end = 155281786
    | Hs_Uniprot = O15085
    | Mm_EntrezGene = 213498
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = XM_986202
    | Mm_RefseqProtein = XP_991296
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Rho guanine nucleotide exchange factor (GEF) 11''', also known as '''ARHGEF11''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9826| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described.<ref name="entrez">{{cite web | title = Entrez Gene: ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9826| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
ARHGEF11 has been shown to [[Protein-protein interaction|interact]] with [[PLXNB3]],<ref name=pmid12183458>{{cite journal | vauthors = Perrot V, Vazquez-Prado J, Gutkind JS | title = Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF | journal = The Journal of Biological Chemistry | volume = 277 | issue = 45 | pages = 43115–20 | date = Nov 2002 | pmid = 12183458 | doi = 10.1074/jbc.M206005200 }}</ref><ref name=pmid12123608>{{cite journal | vauthors = Swiercz JM, Kuner R, Behrens J, Offermanns S | title = Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology | journal = Neuron | volume = 35 | issue = 1 | pages = 51–63 | date = Jul 2002 | pmid = 12123608 | doi = 10.1016/S0896-6273(02)00750-X }}</ref> [[PLXNB1]],<ref name=pmid12183458/><ref name=pmid12123608/><ref name=pmid12730235>{{cite journal | vauthors = Oinuma I, Katoh H, Harada A, Negishi M | title = Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells | journal = The Journal of Biological Chemistry | volume = 278 | issue = 28 | pages = 25671–7 | date = Jul 2003 | pmid = 12730235 | doi = 10.1074/jbc.M303047200 }}</ref><ref name=pmid12220504>{{cite journal | vauthors = Hirotani M, Ohoka Y, Yamamoto T, Nirasawa H, Furuyama T, Kogo M, Matsuya T, Inagaki S | title = Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors | journal = Biochemical and Biophysical Research Communications | volume = 297 | issue = 1 | pages = 32–7 | date = Sep 2002 | pmid = 12220504 | doi = 10.1016/S0006-291X(02)02122-8 }}</ref> [[PLXNB2]]<ref name=pmid12183458/><ref name=pmid12123608/> and [[RHOA]].<ref name=pmid10526156 />
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Fukuhara S, Murga C, Zohar M, Igishi T, Gutkind JS | title = A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho | journal = The Journal of Biological Chemistry | volume = 274 | issue = 9 | pages = 5868–79 | date = Feb 1999 | pmid = 10026210 | doi = 10.1074/jbc.274.9.5868 }}
| citations =
* {{cite journal | vauthors = Togashi H, Nagata K, Takagishi M, Saitoh N, Inagaki M | title = Functions of a rho-specific guanine nucleotide exchange factor in neurite retraction. Possible role of a proline-rich motif of KIAA0380 in localization | journal = The Journal of Biological Chemistry | volume = 275 | issue = 38 | pages = 29570–8 | date = Sep 2000 | pmid = 10900204 | doi = 10.1074/jbc.M003726200 }}
*{{cite journal | author=Nagase T, Ishikawa K, Nakajima D, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=4 |issue= 2 |pages= 141-50 |year= 1997 |pmid= 9205841 |doi=  }}
* {{cite journal | vauthors = Jackson M, Song W, Liu MY, Jin L, Dykes-Hoberg M, Lin CI, Bowers WJ, Federoff HJ, Sternweis PC, Rothstein JD | title = Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins | journal = Nature | volume = 410 | issue = 6824 | pages = 89–93 | date = Mar 2001 | pmid = 11242047 | doi = 10.1038/35065091 }}
*{{cite journal  | author=Fukuhara S, Murga C, Zohar M, ''et al.'' |title=A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho. |journal=J. Biol. Chem. |volume=274 |issue= 9 |pages= 5868-79 |year= 1999 |pmid= 10026210 |doi= }}
* {{cite journal | vauthors = Longenecker KL, Lewis ME, Chikumi H, Gutkind JS, Derewenda ZS | title = Structure of the RGS-like domain from PDZ-RhoGEF: linking heterotrimeric g protein-coupled signaling to Rho GTPases | journal = Structure | volume = 9 | issue = 7 | pages = 559–69 | date = Jul 2001 | pmid = 11470431 | doi = 10.1016/S0969-2126(01)00620-7 }}
*{{cite journal  | author=Rümenapp U, Blomquist A, Schwörer G, ''et al.'' |title=Rho-specific binding and guanine nucleotide exchange catalysis by KIAA0380, a dbl family member. |journal=FEBS Lett. |volume=459 |issue= 3 |pages= 313-8 |year= 1999 |pmid= 10526156 |doi=  }}
* {{cite journal | vauthors = Perrot V, Vazquez-Prado J, Gutkind JS | title = Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF | journal = The Journal of Biological Chemistry | volume = 277 | issue = 45 | pages = 43115–20 | date = Nov 2002 | pmid = 12183458 | doi = 10.1074/jbc.M206005200 }}
*{{cite journal | author=Togashi H, Nagata K, Takagishi M, ''et al.'' |title=Functions of a rho-specific guanine nucleotide exchange factor in neurite retraction. Possible role of a proline-rich motif of KIAA0380 in localization. |journal=J. Biol. Chem. |volume=275 |issue= 38 |pages= 29570-8 |year= 2000 |pmid= 10900204 |doi= 10.1074/jbc.M003726200 }}
* {{cite journal | vauthors = Driessens MH, Olivo C, Nagata K, Inagaki M, Collard JG | title = B plexins activate Rho through PDZ-RhoGEF | journal = FEBS Letters | volume = 529 | issue = 2-3 | pages = 168–72 | date = Oct 2002 | pmid = 12372594 | doi = 10.1016/S0014-5793(02)03323-9 }}
*{{cite journal | author=Jackson M, Song W, Liu MY, ''et al.'' |title=Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins. |journal=Nature |volume=410 |issue= 6824 |pages= 89-93 |year= 2001 |pmid= 11242047 |doi= 10.1038/35065091 }}
* {{cite journal | vauthors = Nakayama M, Kikuno R, Ohara O | title = Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs | journal = Genome Research | volume = 12 | issue = 11 | pages = 1773–84 | date = Nov 2002 | pmid = 12421765 | pmc = 187542 | doi = 10.1101/gr.406902 }}
*{{cite journal | author=Longenecker KL, Lewis ME, Chikumi H, ''et al.'' |title=Structure of the RGS-like domain from PDZ-RhoGEF: linking heterotrimeric g protein-coupled signaling to Rho GTPases. |journal=Structure |volume=9 |issue= 7 |pages= 559-69 |year= 2001 |pmid= 11470431 |doi= }}
* {{cite journal | vauthors = Barac A, Basile J, Vázquez-Prado J, Gao Y, Zheng Y, Gutkind JS | title = Direct interaction of p21-activated kinase 4 with PDZ-RhoGEF, a G protein-linked Rho guanine exchange factor | journal = The Journal of Biological Chemistry | volume = 279 | issue = 7 | pages = 6182–9 | date = Feb 2004 | pmid = 14625312 | doi = 10.1074/jbc.M309579200 }}
*{{cite journal | author=Perrot V, Vazquez-Prado J, Gutkind JS |title=Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF. |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 43115-20 |year= 2003 |pmid= 12183458 |doi= 10.1074/jbc.M206005200 }}
* {{cite journal | vauthors = Davidkova G, McCullumsmith RE, Meador-Woodruff JH | title = Expression of ARHGEF11 mRNA in schizophrenic thalamus | journal = Annals of the New York Academy of Sciences | volume = 1003 | issue =  | pages = 375–7 | date = Nov 2003 | pmid = 14684465 | doi = 10.1196/annals.1300.030 }}
*{{cite journal | author=Driessens MH, Olivo C, Nagata K, ''et al.'' |title=B plexins activate Rho through PDZ-RhoGEF. |journal=FEBS Lett. |volume=529 |issue= 2-3 |pages= 168-72 |year= 2002 |pmid= 12372594 |doi= }}
* {{cite journal | vauthors = Banerjee J, Wedegaertner PB | title = Identification of a novel sequence in PDZ-RhoGEF that mediates interaction with the actin cytoskeleton | journal = Molecular Biology of the Cell | volume = 15 | issue = 4 | pages = 1760–75 | date = Apr 2004 | pmid = 14742719 | pmc = 379273 | doi = 10.1091/mbc.E03-07-0527 }}
*{{cite journal | author=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773-84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902 }}
* {{cite journal | vauthors = Wang Q, Liu M, Kozasa T, Rothstein JD, Sternweis PC, Neubig RR | title = Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells | journal = The Journal of Biological Chemistry | volume = 279 | issue = 28 | pages = 28831–4 | date = Jul 2004 | pmid = 15143072 | doi = 10.1074/jbc.C400105200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Guo X, Li Y, Peng K, Hu Y, Li C, Xia B, Jin C | title = Solution structures and backbone dynamics of arsenate reductase from Bacillus subtilis: reversible conformational switch associated with arsenate reduction | journal = The Journal of Biological Chemistry | volume = 280 | issue = 47 | pages = 39601–8 | date = Nov 2005 | pmid = 16192272 | doi = 10.1074/jbc.M508132200 }}
*{{cite journal  | author=Barac A, Basile J, Vázquez-Prado J, ''et al.'' |title=Direct interaction of p21-activated kinase 4 with PDZ-RhoGEF, a G protein-linked Rho guanine exchange factor. |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 6182-9 |year= 2004 |pmid= 14625312 |doi= 10.1074/jbc.M309579200 }}
* {{cite journal | vauthors = Longhurst DM, Watanabe M, Rothstein JD, Jackson M | title = Interaction of PDZRhoGEF with microtubule-associated protein 1 light chains: link between microtubules, actin cytoskeleton, and neuronal polarity | journal = The Journal of Biological Chemistry | volume = 281 | issue = 17 | pages = 12030–40 | date = Apr 2006 | pmid = 16478718 | doi = 10.1074/jbc.M513756200 }}
*{{cite journal | author=Davidkova G, McCullumsmith RE, Meador-Woodruff JH |title=Expression of ARHGEF11 mRNA in schizophrenic thalamus. |journal=Ann. N. Y. Acad. Sci. |volume=1003 |issue=  |pages= 375-7 |year= 2004 |pmid= 14684465 |doi= }}
* {{cite journal | vauthors = Gu J, Wu X, Dong Q, Romeo MJ, Lin X, Gutkind JS, Berman DM | title = A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans | journal = Cancer | volume = 106 | issue = 12 | pages = 2716–24 | date = Jun 2006 | pmid = 16691626 | doi = 10.1002/cncr.21944 }}
*{{cite journal | author=Banerjee J, Wedegaertner PB |title=Identification of a novel sequence in PDZ-RhoGEF that mediates interaction with the actin cytoskeleton. |journal=Mol. Biol. Cell |volume=15 |issue= 4 |pages= 1760-75 |year= 2004 |pmid= 14742719 |doi= 10.1091/mbc.E03-07-0527 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = Nov 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Wang Q, Liu M, Kozasa T, ''et al.'' |title=Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells. |journal=J. Biol. Chem. |volume=279 |issue= 28 |pages= 28831-4 |year= 2004 |pmid= 15143072 |doi= 10.1074/jbc.C400105200 }}
* {{cite journal | vauthors = Ma L, Hanson RL, Que LN, Cali AM, Fu M, Mack JL, Infante AM, Kobes S, Bogardus C, Shuldiner AR, Baier LJ | title = Variants in ARHGEF11, a candidate gene for the linkage to type 2 diabetes on chromosome 1q, are nominally associated with insulin resistance and type 2 diabetes in Pima Indians | journal = Diabetes | volume = 56 | issue = 5 | pages = 1454–9 | date = May 2007 | pmid = 17287471 | doi = 10.2337/db06-0640 }}
*{{cite journal | author=Guo X, Li Y, Peng K, ''et al.'' |title=Solution structures and backbone dynamics of arsenate reductase from Bacillus subtilis: reversible conformational switch associated with arsenate reduction. |journal=J. Biol. Chem. |volume=280 |issue= 47 |pages= 39601-8 |year= 2006 |pmid= 16192272 |doi= 10.1074/jbc.M508132200 }}
*{{cite journal | author=Longhurst DM, Watanabe M, Rothstein JD, Jackson M |title=Interaction of PDZRhoGEF with microtubule-associated protein 1 light chains: link between microtubules, actin cytoskeleton, and neuronal polarity. |journal=J. Biol. Chem. |volume=281 |issue= 17 |pages= 12030-40 |year= 2006 |pmid= 16478718 |doi= 10.1074/jbc.M513756200 }}
*{{cite journal | author=Gu J, Wu X, Dong Q, ''et al.'' |title=A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans. |journal=Cancer |volume=106 |issue= 12 |pages= 2716-24 |year= 2006 |pmid= 16691626 |doi= 10.1002/cncr.21944 }}
*{{cite journal | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Ma L, Hanson RL, Que LN, ''et al.'' |title=Variants in ARHGEF11, a candidate gene for the linkage to type 2 diabetes on chromosome 1q, are nominally associated with insulin resistance and type 2 diabetes in Pima Indians. |journal=Diabetes |volume=56 |issue= 5 |pages= 1454-9 |year= 2007 |pmid= 17287471 |doi= 10.2337/db06-0640 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{UCSC gene info|ARHGEF11}}
{{PDB Gallery|geneid=9826}}
 
 
{{gene-1-stub}}

Latest revision as of 02:06, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Rho guanine nucleotide exchange factor 11 is a protein that in humans is encoded by the ARHGEF11 gene.[1][2][3]

Function

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described.[3]

Interactions

ARHGEF11 has been shown to interact with PLXNB3,[4][5] PLXNB1,[4][5][6][7] PLXNB2[4][5] and RHOA.[1]

References

  1. ↑ 1.0 1.1 Rümenapp U, Blomquist A, Schwörer G, Schablowski H, Psoma A, Jakobs KH (Oct 1999). "Rho-specific binding and guanine nucleotide exchange catalysis by KIAA0380, a dbl family member". FEBS Letters. 459 (3): 313–8. doi:10.1016/S0014-5793(99)01270-3. PMID 10526156.
  2. ↑ Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
  3. ↑ 3.0 3.1 "Entrez Gene: ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11".
  4. ↑ 4.0 4.1 4.2 Perrot V, Vazquez-Prado J, Gutkind JS (Nov 2002). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". The Journal of Biological Chemistry. 277 (45): 43115–20. doi:10.1074/jbc.M206005200. PMID 12183458.
  5. ↑ 5.0 5.1 5.2 Swiercz JM, Kuner R, Behrens J, Offermanns S (Jul 2002). "Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology". Neuron. 35 (1): 51–63. doi:10.1016/S0896-6273(02)00750-X. PMID 12123608.
  6. ↑ Oinuma I, Katoh H, Harada A, Negishi M (Jul 2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells". The Journal of Biological Chemistry. 278 (28): 25671–7. doi:10.1074/jbc.M303047200. PMID 12730235.
  7. ↑ Hirotani M, Ohoka Y, Yamamoto T, Nirasawa H, Furuyama T, Kogo M, Matsuya T, Inagaki S (Sep 2002). "Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors". Biochemical and Biophysical Research Communications. 297 (1): 32–7. doi:10.1016/S0006-291X(02)02122-8. PMID 12220504.

Further reading

  • Fukuhara S, Murga C, Zohar M, Igishi T, Gutkind JS (Feb 1999). "A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho". The Journal of Biological Chemistry. 274 (9): 5868–79. doi:10.1074/jbc.274.9.5868. PMID 10026210.
  • Togashi H, Nagata K, Takagishi M, Saitoh N, Inagaki M (Sep 2000). "Functions of a rho-specific guanine nucleotide exchange factor in neurite retraction. Possible role of a proline-rich motif of KIAA0380 in localization". The Journal of Biological Chemistry. 275 (38): 29570–8. doi:10.1074/jbc.M003726200. PMID 10900204.
  • Jackson M, Song W, Liu MY, Jin L, Dykes-Hoberg M, Lin CI, Bowers WJ, Federoff HJ, Sternweis PC, Rothstein JD (Mar 2001). "Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins". Nature. 410 (6824): 89–93. doi:10.1038/35065091. PMID 11242047.
  • Longenecker KL, Lewis ME, Chikumi H, Gutkind JS, Derewenda ZS (Jul 2001). "Structure of the RGS-like domain from PDZ-RhoGEF: linking heterotrimeric g protein-coupled signaling to Rho GTPases". Structure. 9 (7): 559–69. doi:10.1016/S0969-2126(01)00620-7. PMID 11470431.
  • Perrot V, Vazquez-Prado J, Gutkind JS (Nov 2002). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". The Journal of Biological Chemistry. 277 (45): 43115–20. doi:10.1074/jbc.M206005200. PMID 12183458.
  • Driessens MH, Olivo C, Nagata K, Inagaki M, Collard JG (Oct 2002). "B plexins activate Rho through PDZ-RhoGEF". FEBS Letters. 529 (2–3): 168–72. doi:10.1016/S0014-5793(02)03323-9. PMID 12372594.
  • Nakayama M, Kikuno R, Ohara O (Nov 2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Research. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
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External links


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