ARHGEF1: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Rho guanine nucleotide exchange factor 1''' is a [[protein]] that in humans is encoded by the ''ARHGEF1'' [[gene]].<ref name="pmid8810315">{{cite journal | vauthors = Hart MJ, Sharma S, elMasry N, Qiu RG, McCabe P, Polakis P, Bollag G | title = Identification of a novel guanine nucleotide exchange factor for the Rho GTPase | journal = J Biol Chem | volume = 271 | issue = 41 | pages = 25452–8 | date = Nov 1996 | pmid = 8810315 | pmc =  | doi = 10.1074/jbc.271.41.25452 }}</ref><ref name="pmid9135076">{{cite journal | vauthors = Aasheim HC, Pedeutour F, Smeland EB | title = Characterization, expression and chromosomal localization of a human gene homologous to the mouse Lsc oncogene, with strongest expression in hematopoetic tissues | journal = Oncogene | volume = 14 | issue = 14 | pages = 1747–52 | date = May 1997 | pmid = 9135076 | pmc = | doi = 10.1038/sj.onc.1200994 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9138| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_ARHGEF1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1iap.
| PDB = {{PDB2|1iap}}, {{PDB2|1shz}}
| Name = Rho guanine nucleotide exchange factor (GEF) 1
| HGNCid = 681
| Symbol = ARHGEF1
| AltSymbols =; GEF1; LBCL2; P115-RHOGEF; SUB1.5
| OMIM = 601855
| ECnumber = 
| Homologene = 3454
| MGIid = 1353510
| GeneAtlas_image1 = PBB_GE_ARHGEF1_203055_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005085 |text = guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0005089 |text = Rho guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0005096 |text = GTPase activator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0035023 |text = regulation of Rho protein signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9138
    | Hs_Ensembl = ENSG00000076928
    | Hs_RefseqProtein = NP_004697
    | Hs_RefseqmRNA = NM_004706
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 47079090
    | Hs_GenLoc_end = 47103437
    | Hs_Uniprot = Q92888
    | Mm_EntrezGene = 16801
    | Mm_Ensembl = ENSMUSG00000040940
    | Mm_RefseqmRNA = NM_008488
    | Mm_RefseqProtein = NP_032514
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 24616494
    | Mm_GenLoc_end = 24634891
    | Mm_Uniprot = Q6KAM6
  }}
}}
'''Rho guanine nucleotide exchange factor (GEF) 1''', also known as '''ARHGEF1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9138| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.<ref name="entrez">{{cite web | title = Entrez Gene: ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9138| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
ARHGEF1 has been shown to [[Protein-protein interaction|interact]] with:
* [[CD44]],<ref name = "pmid14634662" />
* [[GNA12]],<ref name = pmid14634662/>
* [[GNA13]],<ref name = "pmid14634662">{{cite journal | vauthors = Johnson EN, Seasholtz TM, Waheed AA, Kreutz B, Suzuki N, Kozasa T, Jones TL, Brown JH, Druey KM | title = RGS16 inhibits signalling through the G alpha 13-Rho axis | journal = Nat. Cell Biol. | volume = 5 | issue = 12 | pages = 1095–103 | pmid = 14634662 | doi = 10.1038/ncb1065 }}</ref><ref name = pmid12681510>{{cite journal | vauthors = Bhattacharyya R, Wedegaertner PB | title = Mutation of an N-terminal acidic-rich region of p115-RhoGEF dissociates alpha13 binding and alpha13-promoted plasma membrane recruitment | journal = FEBS Lett. | volume = 540 | issue = 1-3 | pages = 211–6 | date = Apr 2003 | pmid = 12681510 | doi =  10.1016/s0014-5793(03)00267-9}}</ref><ref name = pmid9641916>{{cite journal | vauthors = Hart MJ, Jiang X, Kozasa T, Roscoe W, Singer WD, Gilman AG, Sternweis PC, Bollag G | title = Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13 | journal = Science | volume = 280 | issue = 5372 | pages = 2112–4 | date = Jun 1998 | pmid = 9641916 | doi =  10.1126/science.280.5372.2112}}</ref>  and
* [[P110α]]<ref name = pmid12754211>{{cite journal | vauthors = Holinstat M, Mehta D, Kozasa T, Minshall RD, Malik AB | title = Protein kinase Calpha-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement | journal = J. Biol. Chem. | volume = 278 | issue = 31 | pages = 28793–8 | date = Aug 2003 | pmid = 12754211 | doi = 10.1074/jbc.M303900200 }}</ref>
 
== References ==
{{reflist}}
{{Clear}}
 
==External links==
* {{UCSC gene info|ARHGEF1}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Fukuhara S, Chikumi H, Gutkind JS | title = RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho? | journal = Oncogene | volume = 20 | issue = 13 | pages = 1661–8 | year = 2001 | pmid = 11313914 | doi = 10.1038/sj.onc.1204182 }}
| citations =
* {{cite journal | vauthors = Kozasa T, Jiang X, Hart MJ, Sternweis PM, Singer WD, Gilman AG, Bollag G, Sternweis PC | title = p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13 | journal = Science | volume = 280 | issue = 5372 | pages = 2109–11 | year = 1998 | pmid = 9641915 | doi = 10.1126/science.280.5372.2109 }}
*{{cite journal | author=Fukuhara S, Chikumi H, Gutkind JS |title=RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho? |journal=Oncogene |volume=20 |issue= 13 |pages= 1661-8 |year= 2001 |pmid= 11313914 |doi= 10.1038/sj.onc.1204182 }}
* {{cite journal | vauthors = Hart MJ, Jiang X, Kozasa T, Roscoe W, Singer WD, Gilman AG, Sternweis PC, Bollag G | title = Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13 | journal = Science | volume = 280 | issue = 5372 | pages = 2112–4 | year = 1998 | pmid = 9641916 | doi = 10.1126/science.280.5372.2112 }}
*{{cite journal | author=Hart MJ, Sharma S, elMasry N, ''et al.'' |title=Identification of a novel guanine nucleotide exchange factor for the Rho GTPase. |journal=J. Biol. Chem. |volume=271 |issue= 41 |pages= 25452-8 |year= 1996 |pmid= 8810315 |doi=  }}
* {{cite journal | vauthors = Zhang H, Wang L, Kao S, Whitehead IP, Hart MJ, Liu B, Duus K, Burridge K, Der CJ, Su L | title = Functional interaction between the cytoplasmic leucine-zipper domain of HIV-1 gp41 and p115-RhoGEF | journal = Curr. Biol. | volume = 9 | issue = 21 | pages = 1271–4 | year = 1999 | pmid = 10556093 | doi = 10.1016/S0960-9822(99)80511-9 }}
*{{cite journal  | author=Aasheim HC, Pedeutour F, Smeland EB |title=Characterization, expression and chromosomal localization of a human gene homologous to the mouse Lsc oncogene, with strongest expression in hematopoetic tissues. |journal=Oncogene |volume=14 |issue= 14 |pages= 1747-52 |year= 1997 |pmid= 9135076 |doi= 10.1038/sj.onc.1200994 }}
* {{cite journal | vauthors = Kim ST, Lim DS, Canman CE, Kastan MB | title = Substrate specificities and identification of putative substrates of ATM kinase family members | journal = J. Biol. Chem. | volume = 274 | issue = 53 | pages = 37538–43 | year = 2000 | pmid = 10608806 | doi = 10.1074/jbc.274.53.37538 }}
*{{cite journal  | author=Kozasa T, Jiang X, Hart MJ, ''et al.'' |title=p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13. |journal=Science |volume=280 |issue= 5372 |pages= 2109-11 |year= 1998 |pmid= 9641915 |doi= }}
* {{cite journal | vauthors = Bhattacharyya R, Wedegaertner PB | title = Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding | journal = J. Biol. Chem. | volume = 275 | issue = 20 | pages = 14992–9 | year = 2000 | pmid = 10747909 | doi = 10.1074/jbc.M000415200 }}
*{{cite journal | author=Hart MJ, Jiang X, Kozasa T, ''et al.'' |title=Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13. |journal=Science |volume=280 |issue= 5372 |pages= 2112-4 |year= 1998 |pmid= 9641916 |doi= }}
* {{cite journal | vauthors = Kozasa T | title = Regulation of G protein-mediated signal transduction by RGS proteins | journal = Life Sci. | volume = 68 | issue = 19–20 | pages = 2309–17 | year = 2001 | pmid = 11358341 | doi = 10.1016/S0024-3205(01)01020-7 }}
*{{cite journal | author=Zhang H, Wang L, Kao S, ''et al.'' |title=Functional interaction between the cytoplasmic leucine-zipper domain of HIV-1 gp41 and p115-RhoGEF. |journal=Curr. Biol. |volume=9 |issue= 21 |pages= 1271-4 |year= 1999 |pmid= 10556093 |doi= }}
* {{cite journal | vauthors = Wells CD, Gutowski S, Bollag G, Sternweis PC | title = Identification of potential mechanisms for regulation of p115 RhoGEF through analysis of endogenous and mutant forms of the exchange factor | journal = J. Biol. Chem. | volume = 276 | issue = 31 | pages = 28897–905 | year = 2001 | pmid = 11384980 | doi = 10.1074/jbc.M102913200 }}
*{{cite journal | author=Kim ST, Lim DS, Canman CE, Kastan MB |title=Substrate specificities and identification of putative substrates of ATM kinase family members. |journal=J. Biol. Chem. |volume=274 |issue= 53 |pages= 37538-43 |year= 2000 |pmid= 10608806 |doi= }}
* {{cite journal | vauthors = Chen Z, Wells CD, Sternweis PC, Sprang SR | title = Structure of the rgRGS domain of p115RhoGEF | journal = Nat. Struct. Biol. | volume = 8 | issue = 9 | pages = 805–9 | year = 2001 | pmid = 11524686 | doi = 10.1038/nsb0901-805 }}
*{{cite journal | author=Bhattacharyya R, Wedegaertner PB |title=Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding. |journal=J. Biol. Chem. |volume=275 |issue= 20 |pages= 14992-9 |year= 2000 |pmid= 10747909 |doi= 10.1074/jbc.M000415200 }}
* {{cite journal | vauthors = Park B, Nguyen NT, Dutt P, Merdek KD, Bashar M, Sterpetti P, Tosolini A, Testa JR, Toksoz D | title = Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation | journal = J. Biol. Chem. | volume = 277 | issue = 47 | pages = 45361–70 | year = 2003 | pmid = 12270917 | doi = 10.1074/jbc.M202447200 }}
*{{cite journal | author=Kozasa T |title=Regulation of G protein-mediated signal transduction by RGS proteins. |journal=Life Sci. |volume=68 |issue= 19-20 |pages= 2309-17 |year= 2001 |pmid= 11358341 |doi= }}
* {{cite journal | vauthors = Driessens MH, Olivo C, Nagata K, Inagaki M, Collard JG | title = B plexins activate Rho through PDZ-RhoGEF | journal = FEBS Lett. | volume = 529 | issue = 2–3 | pages = 168–72 | year = 2002 | pmid = 12372594 | doi = 10.1016/S0014-5793(02)03323-9 }}
*{{cite journal | author=Wells CD, Gutowski S, Bollag G, Sternweis PC |title=Identification of potential mechanisms for regulation of p115 RhoGEF through analysis of endogenous and mutant forms of the exchange factor. |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 28897-905 |year= 2001 |pmid= 11384980 |doi= 10.1074/jbc.M102913200 }}
* {{cite journal | vauthors = Chen Z, Singer WD, Wells CD, Sprang SR, Sternweis PC | title = Mapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEF | journal = J. Biol. Chem. | volume = 278 | issue = 11 | pages = 9912–9 | year = 2003 | pmid = 12525488 | doi = 10.1074/jbc.M212695200 }}
*{{cite journal | author=Chen Z, Wells CD, Sternweis PC, Sprang SR |title=Structure of the rgRGS domain of p115RhoGEF. |journal=Nat. Struct. Biol. |volume=8 |issue= 9 |pages= 805-9 |year= 2001 |pmid= 11524686 |doi= 10.1038/nsb0901-805 }}
* {{cite journal | vauthors = Bhattacharyya R, Wedegaertner PB | title = Characterization of G alpha 13-dependent plasma membrane recruitment of p115RhoGEF | journal = Biochem. J. | volume = 371 | issue = Pt 3 | pages = 709–20 | year = 2003 | pmid = 12534370 | pmc = 1223324 | doi = 10.1042/BJ20021897 }}
*{{cite journal | author=Park B, Nguyen NT, Dutt P, ''et al.'' |title=Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation. |journal=J. Biol. Chem. |volume=277 |issue= 47 |pages= 45361-70 |year= 2003 |pmid= 12270917 |doi= 10.1074/jbc.M202447200 }}
* {{cite journal | vauthors = Bhattacharyya R, Wedegaertner PB | title = Mutation of an N-terminal acidic-rich region of p115-RhoGEF dissociates alpha13 binding and alpha13-promoted plasma membrane recruitment | journal = FEBS Lett. | volume = 540 | issue = 1–3 | pages = 211–6 | year = 2003 | pmid = 12681510 | doi = 10.1016/S0014-5793(03)00267-9 }}
*{{cite journal | author=Driessens MH, Olivo C, Nagata K, ''et al.'' |title=B plexins activate Rho through PDZ-RhoGEF. |journal=FEBS Lett. |volume=529 |issue= 2-3 |pages= 168-72 |year= 2002 |pmid= 12372594 |doi= }}
* {{cite journal | vauthors = Bourguignon LY, Singleton PA, Zhu H, Diedrich F | title = Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression | journal = J. Biol. Chem. | volume = 278 | issue = 32 | pages = 29420–34 | year = 2003 | pmid = 12748184 | doi = 10.1074/jbc.M301885200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Holinstat M, Mehta D, Kozasa T, Minshall RD, Malik AB | title = Protein kinase Calpha-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement | journal = J. Biol. Chem. | volume = 278 | issue = 31 | pages = 28793–8 | year = 2003 | pmid = 12754211 | doi = 10.1074/jbc.M303900200 }}
*{{cite journal | author=Chen Z, Singer WD, Wells CD, ''et al.'' |title=Mapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEF. |journal=J. Biol. Chem. |volume=278 |issue= 11 |pages= 9912-9 |year= 2003 |pmid= 12525488 |doi= 10.1074/jbc.M212695200 }}
*{{cite journal | author=Bhattacharyya R, Wedegaertner PB |title=Characterization of G alpha 13-dependent plasma membrane recruitment of p115RhoGEF. |journal=Biochem. J. |volume=371 |issue= Pt 3 |pages= 709-20 |year= 2003 |pmid= 12534370 |doi= 10.1042/BJ20021897 }}
*{{cite journal | author=Bhattacharyya R, Wedegaertner PB |title=Mutation of an N-terminal acidic-rich region of p115-RhoGEF dissociates alpha13 binding and alpha13-promoted plasma membrane recruitment. |journal=FEBS Lett. |volume=540 |issue= 1-3 |pages= 211-6 |year= 2003 |pmid= 12681510 |doi= }}
*{{cite journal | author=Bourguignon LY, Singleton PA, Zhu H, Diedrich F |title=Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression. |journal=J. Biol. Chem. |volume=278 |issue= 32 |pages= 29420-34 |year= 2003 |pmid= 12748184 |doi= 10.1074/jbc.M301885200 }}
*{{cite journal | author=Holinstat M, Mehta D, Kozasa T, ''et al.'' |title=Protein kinase Calpha-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement. |journal=J. Biol. Chem. |volume=278 |issue= 31 |pages= 28793-8 |year= 2003 |pmid= 12754211 |doi= 10.1074/jbc.M303900200 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=9138}}
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{{gene-19-stub}}

Latest revision as of 18:13, 29 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Rho guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the ARHGEF1 gene.[1][2][3]

Function

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.[3]

Interactions

ARHGEF1 has been shown to interact with:

References

  1. ↑ Hart MJ, Sharma S, elMasry N, Qiu RG, McCabe P, Polakis P, Bollag G (Nov 1996). "Identification of a novel guanine nucleotide exchange factor for the Rho GTPase". J Biol Chem. 271 (41): 25452–8. doi:10.1074/jbc.271.41.25452. PMID 8810315.
  2. ↑ Aasheim HC, Pedeutour F, Smeland EB (May 1997). "Characterization, expression and chromosomal localization of a human gene homologous to the mouse Lsc oncogene, with strongest expression in hematopoetic tissues". Oncogene. 14 (14): 1747–52. doi:10.1038/sj.onc.1200994. PMID 9135076.
  3. ↑ 3.0 3.1 "Entrez Gene: ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1".
  4. ↑ 4.0 4.1 4.2 Johnson EN, Seasholtz TM, Waheed AA, Kreutz B, Suzuki N, Kozasa T, Jones TL, Brown JH, Druey KM. "RGS16 inhibits signalling through the G alpha 13-Rho axis". Nat. Cell Biol. 5 (12): 1095–103. doi:10.1038/ncb1065. PMID 14634662.
  5. ↑ Bhattacharyya R, Wedegaertner PB (Apr 2003). "Mutation of an N-terminal acidic-rich region of p115-RhoGEF dissociates alpha13 binding and alpha13-promoted plasma membrane recruitment". FEBS Lett. 540 (1–3): 211–6. doi:10.1016/s0014-5793(03)00267-9. PMID 12681510.
  6. ↑ Hart MJ, Jiang X, Kozasa T, Roscoe W, Singer WD, Gilman AG, Sternweis PC, Bollag G (Jun 1998). "Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13". Science. 280 (5372): 2112–4. doi:10.1126/science.280.5372.2112. PMID 9641916.
  7. ↑ Holinstat M, Mehta D, Kozasa T, Minshall RD, Malik AB (Aug 2003). "Protein kinase Calpha-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement". J. Biol. Chem. 278 (31): 28793–8. doi:10.1074/jbc.M303900200. PMID 12754211.

External links

Further reading

  • Fukuhara S, Chikumi H, Gutkind JS (2001). "RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho?". Oncogene. 20 (13): 1661–8. doi:10.1038/sj.onc.1204182. PMID 11313914.
  • Kozasa T, Jiang X, Hart MJ, Sternweis PM, Singer WD, Gilman AG, Bollag G, Sternweis PC (1998). "p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13". Science. 280 (5372): 2109–11. doi:10.1126/science.280.5372.2109. PMID 9641915.
  • Hart MJ, Jiang X, Kozasa T, Roscoe W, Singer WD, Gilman AG, Sternweis PC, Bollag G (1998). "Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13". Science. 280 (5372): 2112–4. doi:10.1126/science.280.5372.2112. PMID 9641916.
  • Zhang H, Wang L, Kao S, Whitehead IP, Hart MJ, Liu B, Duus K, Burridge K, Der CJ, Su L (1999). "Functional interaction between the cytoplasmic leucine-zipper domain of HIV-1 gp41 and p115-RhoGEF". Curr. Biol. 9 (21): 1271–4. doi:10.1016/S0960-9822(99)80511-9. PMID 10556093.
  • Kim ST, Lim DS, Canman CE, Kastan MB (2000). "Substrate specificities and identification of putative substrates of ATM kinase family members". J. Biol. Chem. 274 (53): 37538–43. doi:10.1074/jbc.274.53.37538. PMID 10608806.
  • Bhattacharyya R, Wedegaertner PB (2000). "Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding". J. Biol. Chem. 275 (20): 14992–9. doi:10.1074/jbc.M000415200. PMID 10747909.
  • Kozasa T (2001). "Regulation of G protein-mediated signal transduction by RGS proteins". Life Sci. 68 (19–20): 2309–17. doi:10.1016/S0024-3205(01)01020-7. PMID 11358341.
  • Wells CD, Gutowski S, Bollag G, Sternweis PC (2001). "Identification of potential mechanisms for regulation of p115 RhoGEF through analysis of endogenous and mutant forms of the exchange factor". J. Biol. Chem. 276 (31): 28897–905. doi:10.1074/jbc.M102913200. PMID 11384980.
  • Chen Z, Wells CD, Sternweis PC, Sprang SR (2001). "Structure of the rgRGS domain of p115RhoGEF". Nat. Struct. Biol. 8 (9): 805–9. doi:10.1038/nsb0901-805. PMID 11524686.
  • Park B, Nguyen NT, Dutt P, Merdek KD, Bashar M, Sterpetti P, Tosolini A, Testa JR, Toksoz D (2003). "Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation". J. Biol. Chem. 277 (47): 45361–70. doi:10.1074/jbc.M202447200. PMID 12270917.
  • Driessens MH, Olivo C, Nagata K, Inagaki M, Collard JG (2002). "B plexins activate Rho through PDZ-RhoGEF". FEBS Lett. 529 (2–3): 168–72. doi:10.1016/S0014-5793(02)03323-9. PMID 12372594.
  • Chen Z, Singer WD, Wells CD, Sprang SR, Sternweis PC (2003). "Mapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEF". J. Biol. Chem. 278 (11): 9912–9. doi:10.1074/jbc.M212695200. PMID 12525488.
  • Bhattacharyya R, Wedegaertner PB (2003). "Characterization of G alpha 13-dependent plasma membrane recruitment of p115RhoGEF". Biochem. J. 371 (Pt 3): 709–20. doi:10.1042/BJ20021897. PMC 1223324. PMID 12534370.
  • Bhattacharyya R, Wedegaertner PB (2003). "Mutation of an N-terminal acidic-rich region of p115-RhoGEF dissociates alpha13 binding and alpha13-promoted plasma membrane recruitment". FEBS Lett. 540 (1–3): 211–6. doi:10.1016/S0014-5793(03)00267-9. PMID 12681510.
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