ARHGAP1

Rho GTPase activating protein 1
PDB rendering based on 1am4.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1am4​, 1grn​, 1ow3​, 1rgp​, 1tx4​, 2ngr​
Identifiers
Symbols	ARHGAP1 ; CDC42GAP; RHOGAP; RHOGAP1; p50rhoGAP
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20909
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Rho GTPase activating protein 1, also known as ARHGAP1, is a human gene.

Further reading

• Diekmann D, Brill S, Garrett MD; et al. (1991). "Bcr encodes a GTPase-activating protein for p21rac". Nature. 351 (6325): 400–2. doi:10.1038/351400a0. PMID 1903516.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Garrett MD, Major GN, Totty N, Hall A (1991). "Purification and N-terminal sequence of the p21rho GTPase-activating protein, rho GAP". Biochem. J. 276 ( Pt 3): 833–6. PMID 1905930.CS1 maint: Multiple names: authors list (link)
• Barfod ET, Zheng Y, Kuang WJ; et al. (1994). "Cloning and expression of a human CDC42 GTPase-activating protein reveals a functional SH3-binding domain". J. Biol. Chem. 268 (35): 26059–62. PMID 8253717.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lancaster CA, Taylor-Harris PM, Self AJ; et al. (1994). "Characterization of rhoGAP. A GTPase-activating protein for rho-related small GTPases". J. Biol. Chem. 269 (2): 1137–42. PMID 8288572.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Aspenström P, Lindberg U, Hall A (1996). "Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome". Curr. Biol. 6 (1): 70–5. PMID 8805223.CS1 maint: Multiple names: authors list (link)
• Barrett T, Xiao B, Dodson EJ; et al. (1997). "The structure of the GTPase-activating domain from p50rhoGAP". Nature. 385 (6615): 458–61. doi:10.1038/385458a0. PMID 9009196.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hu KQ, Settleman J (1997). "Tandem SH2 binding sites mediate the RasGAP-RhoGAP interaction: a conformational mechanism for SH3 domain regulation". EMBO J. 16 (3): 473–83. doi:10.1093/emboj/16.3.473. PMID 9034330.
• Rittinger K, Walker PA, Eccleston JF; et al. (1997). "Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP". Nature. 388 (6643): 693–7. doi:10.1038/41805. PMID 9262406.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang B, Wang ZX, Zheng Y (1997). "Characterization of the interactions between the small GTPase Cdc42 and its GTPase-activating proteins and putative effectors. Comparison of kinetic properties of Cdc42 binding to the Cdc42-interactive domains". J. Biol. Chem. 272 (35): 21999–2007. PMID 9268338.CS1 maint: Multiple names: authors list (link)
• Li R, Zhang B, Zheng Y (1998). "Structural determinants required for the interaction between Rho GTPase and the GTPase-activating domain of p190". J. Biol. Chem. 272 (52): 32830–5. PMID 9407060.CS1 maint: Multiple names: authors list (link)
• Zhang B, Zheng Y (1998). "Regulation of RhoA GTP hydrolysis by the GTPase-activating proteins p190, p50RhoGAP, Bcr, and 3BP-1". Biochemistry. 37 (15): 5249–57. doi:10.1021/bi9718447. PMID 9548756.
• Low BC, Lim YP, Lim J; et al. (2000). "Tyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by fibroblast growth factor receptor-1 prevents its binding to Cdc42GAP and Cdc42". J. Biol. Chem. 274 (46): 33123–30. PMID 10551883.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Graham DL, Eccleston JF, Chung CW, Lowe PN (1999). "Magnesium fluoride-dependent binding of small G proteins to their GTPase-activating proteins". Biochemistry. 38 (45): 14981–7. PMID 10555980.CS1 maint: Multiple names: authors list (link)
• Low BC, Seow KT, Guy GR (2000). "Evidence for a novel Cdc42GAP domain at the carboxyl terminus of BNIP-2". J. Biol. Chem. 275 (19): 14415–22. PMID 10799524.CS1 maint: Multiple names: authors list (link)
• Low BC, Seow KT, Guy GR (2001). "The BNIP-2 and Cdc42GAP homology domain of BNIP-2 mediates its homophilic association and heterophilic interaction with Cdc42GAP". J. Biol. Chem. 275 (48): 37742–51. doi:10.1074/jbc.M004897200. PMID 10954711.CS1 maint: Multiple names: authors list (link)
• Zhou YT, Soh UJ, Shang X; et al. (2002). "The BNIP-2 and Cdc42GAP homology/Sec14p-like domain of BNIP-Salpha is a novel apoptosis-inducing sequence". J. Biol. Chem. 277 (9): 7483–92. doi:10.1074/jbc.M109459200. PMID 11741952.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fidyk NJ, Cerione RA (2003). "Understanding the catalytic mechanism of GTPase-activating proteins: demonstration of the importance of switch domain stabilization in the stimulation of GTP hydrolysis". Biochemistry. 41 (52): 15644–53. PMID 12501193.
• Qin W, Hu J, Guo M; et al. (2003). "BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis". Biochem. Biophys. Res. Commun. 308 (2): 379–85. PMID 12901880.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shang X, Zhou YT, Low BC (2003). "Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1". J. Biol. Chem. 278 (46): 45903–14. doi:10.1074/jbc.M304514200. PMID 12944407.CS1 maint: Multiple names: authors list (link)