The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.
Aquaporin-7 is a protein that in humans is encoded by the AQP7gene.[1][2]
Aquaporins/major intrinsic protein (MIP) are a family of water-selective membrane channels. Aquaporin 7 has greater sequence similarity with AQP3 and AQP9 and they may be a subfamily. Aquaporin 7 and AQP3 are at the same chromosomal location suggesting that 9p13 may be a site of an aquaporin cluster. Aquaporin 7 facilitates water, glycerol and urea transport. It may play an important role in thermoregulation in the form of perspiration and sperm function.[2]
↑Ishibashi K, Kuwahara M, Gu Y, Kageyama Y, Tohsaka A, Suzuki F, Marumo F, Sasaki S (Sep 1997). "Cloning and functional expression of a new water channel abundantly expressed in the testis permeable to water, glycerol, and urea". J Biol Chem. 272 (33): 20782–6. doi:10.1074/jbc.272.33.20782. PMID9252401.
Dibas AI, Mia AJ, Yorio T (1998). "Aquaporins (water channels): role in vasopressin-activated water transport". Proc. Soc. Exp. Biol. Med. 219 (3): 183–99. doi:10.3181/00379727-219-44332. PMID9824541.
Kuriyama H, Kawamoto S, Ishida N, et al. (1998). "Molecular cloning and expression of a novel human aquaporin from adipose tissue with glycerol permeability". Biochem. Biophys. Res. Commun. 241 (1): 53–8. doi:10.1006/bbrc.1997.7769. PMID9405233.
Ishibashi K, Yamauchi K, Kageyama Y, et al. (1998). "Molecular characterization of human Aquaporin-7 gene and its chromosomal mapping". Biochim. Biophys. Acta. 1399 (1): 62–6. doi:10.1016/s0167-4781(98)00094-3. PMID9714739.
Suzuki-Toyota F, Ishibashi K, Yuasa S (1999). "Immunohistochemical localization of a water channel, aquaporin 7 (AQP7), in the rat testis". Cell Tissue Res. 295 (2): 279–85. doi:10.1007/s004410051234. PMID9931374.
Kondo H, Shimomura I, Kishida K, et al. (2002). "Human aquaporin adipose (AQPap) gene. Genomic structure, promoter analysis and functional mutation". Eur. J. Biochem. 269 (7): 1814–26. doi:10.1046/j.1432-1033.2002.02821.x. PMID11952783.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Marrades MP, Milagro FI, Martínez JA, Moreno-Aliaga MJ (2006). "Differential expression of aquaporin 7 in adipose tissue of lean and obese high fat consumers". Biochem. Biophys. Res. Commun. 339 (3): 785–9. doi:10.1016/j.bbrc.2005.11.080. PMID16325777.
Prudente S, Flex E, Morini E, et al. (2007). "A functional variant of the adipocyte glycerol channel aquaporin 7 gene is associated with obesity and related metabolic abnormalities". Diabetes. 56 (5): 1468–74. doi:10.2337/db06-1389. PMID17351148.
Ceperuelo-Mallafré V, Miranda M, Chacón MR, et al. (2007). "Adipose tissue expression of the glycerol channel aquaporin-7 gene is altered in severe obesity but not in type 2 diabetes". J. Clin. Endocrinol. Metab. 92 (9): 3640–5. doi:10.1210/jc.2007-0531. PMID17566090.
