APPL1

Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
PDB rendering based on 2ela.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2ela​, 2elb​
Identifiers
Symbols	APPL1 ; APPL; DIP13alpha
External IDs	Template:OMIM5 Template:MGI HomoloGene: 32143
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1, also known as APPL1, is a human gene.

The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.

Further reading

• Nakajima D, Okazaki N, Yamakawa H; et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. PMID 12168954.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mitsuuchi Y, Johnson SW, Sonoda G; et al. (1999). "Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2". Oncogene. 18 (35): 4891–8. doi:10.1038/sj.onc.1203080. PMID 10490823.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagase T, Kikuno R, Ishikawa KI; et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. PMID 10718198.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu J, Yao F, Wu R; et al. (2002). "Mediation of the DCC apoptotic signal by DIP13 alpha". J. Biol. Chem. 277 (29): 26281–5. doi:10.1074/jbc.M204679200. PMID 12011067.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang L, Lin HK, Altuwaijri S; et al. (2003). "APPL suppresses androgen receptor transactivation via potentiating Akt activity". J. Biol. Chem. 278 (19): 16820–7. doi:10.1074/jbc.M213163200. PMID 12621049.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miaczynska M, Christoforidis S, Giner A; et al. (2004). "APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment". Cell. 116 (3): 445–56. PMID 15016378.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nechamen CA, Thomas RM, Cohen BD; et al. (2005). "Human follicle-stimulating hormone (FSH) receptor interacts with the adaptor protein APPL1 in HEK 293 cells: potential involvement of the PI3K pathway in FSH signaling". Biol. Reprod. 71 (2): 629–36. doi:10.1095/biolreprod.103.025833. PMID 15070827.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ballif BA, Villén J, Beausoleil SA; et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mao X, Kikani CK, Riojas RA; et al. (2006). "APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function". Nat. Cell Biol. 8 (5): 516–23. doi:10.1038/ncb1404. PMID 16622416.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nechamen CA, Thomas RM, Dias JA (2007). "APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex". Mol. Cell. Endocrinol. 260-262: 93–9. doi:10.1016/j.mce.2006.08.014. PMID 17030088.CS1 maint: Multiple names: authors list (link)
• Cheng KK, Lam KS, Wang Y; et al. (2007). "Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells". Diabetes. 56 (5): 1387–94. doi:10.2337/db06-1580. PMID 17287464.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li J, Mao X, Dong LQ; et al. (2007). "Crystal structures of the BAR-PH and PTB domains of human APPL1". Structure. 15 (5): 525–33. doi:10.1016/j.str.2007.03.011. PMID 17502098.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhu G, Chen J, Liu J; et al. (2007). "Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5". EMBO J. 26 (14): 3484–93. doi:10.1038/sj.emboj.7601771. PMID 17581628.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Saito T, Jones CC, Huang S; et al. (2007). "The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation". J. Biol. Chem. 282 (44): 32280–7. doi:10.1074/jbc.M704150200. PMID 17848569.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)