APOA5
| Apolipoprotein A-V | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | APOA5 ; APOA-V; APOAV; MGC126836; MGC126838; RAP3 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 14197 | ||||||||||
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| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Apolipoprotein A-V, also known as APOA5, is a human gene.
The protein encoded by this gene is an apolipoprotein and an important determinant of plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of several lipoprotein fractions including VLDL, HDL, chylomicrons. It is believed that apoA-V affects lipoprotein metabolism by interacting with LDL-R gene family receptors.[1]
This gene uses alternate polyadenylation sites and is located proximal to the apolipoprotein gene cluster on chromosome 11q23.[2]
See also
References
Further reading
- Pennacchio LA, Rubin EM (2004). "Apolipoprotein A5, a newly identified gene that affects plasma triglyceride levels in humans and mice". Arterioscler. Thromb. Vasc. Biol. 23 (4): 529–34. doi:10.1161/01.ATV.0000054194.78240.45. PMID 12615678.
- Jakel H, Nowak M, Helleboid-Chapman A; et al. (2006). "Is apolipoprotein A5 a novel regulator of triglyceride-rich lipoproteins?". Ann. Med. 38 (1): 2–10. doi:10.1080/07853890500407488. PMID 16448983.
- Calandra S, Priore Oliva C, Tarugi P, Bertolini S (2007). "APOA5 and triglyceride metabolism, lesson from human APOA5 deficiency". Curr. Opin. Lipidol. 17 (2): 122–7. doi:10.1097/01.mol.0000217892.00618.54. PMID 16531747.
- Wong K, Ryan RO (2007). "Characterization of apolipoprotein A-V structure and mode of plasma triacylglycerol regulation". Curr. Opin. Lipidol. 18 (3): 319–24. doi:10.1097/MOL.0b013e328133856c. PMID 17495607.
- van der Vliet HN, Sammels MG, Leegwater AC; et al. (2002). "Apolipoprotein A-V: a novel apolipoprotein associated with an early phase of liver regeneration". J. Biol. Chem. 276 (48): 44512–20. doi:10.1074/jbc.M106888200. PMID 11577099.
- Pennacchio LA, Olivier M, Hubacek JA; et al. (2001). "An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing". Science. 294 (5540): 169–73. doi:10.1126/science.1064852. PMID 11588264.
- Nabika T, Nasreen S, Kobayashi S, Masuda J (2003). "The genetic effect of the apoprotein AV gene on the serum triglyceride level in Japanese". Atherosclerosis. 165 (2): 201–4. PMID 12417270.
- Pennacchio LA, Olivier M, Hubacek JA; et al. (2003). "Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels". Hum. Mol. Genet. 11 (24): 3031–8. PMID 12417524.
- Talmud PJ, Hawe E, Martin S; et al. (2003). "Relative contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides". Hum. Mol. Genet. 11 (24): 3039–46. PMID 12417525.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Vu-Dac N, Gervois P, Jakel H; et al. (2003). "Apolipoprotein A5, a crucial determinant of plasma triglyceride levels, is highly responsive to peroxisome proliferator-activated receptor alpha activators". J. Biol. Chem. 278 (20): 17982–5. doi:10.1074/jbc.M212191200. PMID 12637506.
- Prieur X, Coste H, Rodriguez JC (2003). "The human apolipoprotein AV gene is regulated by peroxisome proliferator-activated receptor-alpha and contains a novel farnesoid X-activated receptor response element". J. Biol. Chem. 278 (28): 25468–80. doi:10.1074/jbc.M301302200. PMID 12709436.
- Weinberg RB, Cook VR, Beckstead JA; et al. (2003). "Structure and interfacial properties of human apolipoprotein A-V". J. Biol. Chem. 278 (36): 34438–44. doi:10.1074/jbc.M303784200. PMID 12810715.
- Horínek A, Vráblík M, Ceska R; et al. (2003). "T-1131-->C polymorphism within the apolipoprotein AV gene in hypertriglyceridemic individuals". Atherosclerosis. 167 (2): 369–70. PMID 12818421.
- Beckstead JA, Oda MN, Martin DD; et al. (2003). "Structure-function studies of human apolipoprotein A-V: a regulator of plasma lipid homeostasis". Biochemistry. 42 (31): 9416–23. doi:10.1021/bi034509t. PMID 12899628.
- Kao JT, Wen HC, Chien KL; et al. (2004). "A novel genetic variant in the apolipoprotein A5 gene is associated with hypertriglyceridemia". Hum. Mol. Genet. 12 (19): 2533–9. doi:10.1093/hmg/ddg255. PMID 12915450.
- Vrablík M, Horínek A, Ceska R; et al. (2003). "Ser19-->Trp polymorphism within the apolipoprotein AV gene in hypertriglyceridaemic people". J. Med. Genet. 40 (8): e105. PMID 12920097.
- Lai CQ, Tai ES, Tan CE; et al. (2004). "The APOA5 locus is a strong determinant of plasma triglyceride concentrations across ethnic groups in Singapore". J. Lipid Res. 44 (12): 2365–73. doi:10.1194/jlr.M300251-JLR200. PMID 12951359.
- Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
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