AP2B1

Adaptor-related protein complex 2, beta 1 subunit
PDB rendering based on 1e42.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1e42​, 1gw5​, 1w63​, 2g30​, 2iv9​
Identifiers
Symbols	AP2B1 ; ADTB2; AP105B; AP2-BETA; CLAPB1; DKFZp781K0743
External IDs	Template:OMIM5 Template:MGI HomoloGene: 68176
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Adaptor-related protein complex 2, beta 1 subunit, also known as AP2B1, is a human gene.

The protein encoded by this gene is one of two large chain components of the assembly protein complex 2, which serves to link clathrin to receptors in coated vesicles. The encoded protein is found on the cytoplasmic face of coated vesicles in the plasma membrane. Two transcript variants encoding different isoforms have been found for this gene.

Further reading

• Kirchhausen T (2000). "Clathrin". Annu. Rev. Biochem. 69: 699–727. doi:10.1146/annurev.biochem.69.1.699. PMID 10966473.
• Geyer M, Fackler OT, Peterlin BM (2001). "Structure--function relationships in HIV-1 Nef". EMBO Rep. 2 (7): 580–5. doi:10.1093/embo-reports/kve141. PMID 11463741.CS1 maint: Multiple names: authors list (link)
• Ponnambalam S, Robinson MS, Jackson AP; et al. (1990). "Conservation and diversity in families of coated vesicle adaptins". J. Biol. Chem. 265 (9): 4814–20. PMID 1969413.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gallusser A, Kirchhausen T (1994). "The beta 1 and beta 2 subunits of the AP complexes are the clathrin coat assembly components". EMBO J. 12 (13): 5237–44. PMID 8262066.
• Druck T, Gu Y, Prabhala G; et al. (1996). "Chromosome localization of human genes for clathrin adaptor polypeptides AP2 beta and AP50 and the clathrin-binding protein, VCP". Genomics. 30 (1): 94–7. doi:10.1006/geno.1995.0016. PMID 8595912.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Greenberg ME, Bronson S, Lock M; et al. (1998). "Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation". EMBO J. 16 (23): 6964–76. doi:10.1093/emboj/16.23.6964. PMID 9384576.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lim DS, Kirsch DG, Canman CE; et al. (1998). "ATM binds to beta-adaptin in cytoplasmic vesicles". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10146–51. PMID 9707615.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Greenberg M, DeTulleo L, Rapoport I; et al. (1999). "A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4". Curr. Biol. 8 (22): 1239–42. PMID 9811611.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Berlioz-Torrent C, Shacklett BL, Erdtmann L; et al. (1999). "Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins". J. Virol. 73 (2): 1350–61. PMID 9882340.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Owen DJ, Vallis Y, Pearse BM; et al. (2000). "The structure and function of the beta 2-adaptin appendage domain". EMBO J. 19 (16): 4216–27. doi:10.1093/emboj/19.16.4216. PMID 10944104.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fan GH, Yang W, Wang XJ; et al. (2001). "Identification of a motif in the carboxyl terminus of CXCR2 that is involved in adaptin 2 binding and receptor internalization". Biochemistry. 40 (3): 791–800. PMID 11170396.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Swigut T, Shohdy N, Skowronski J (2001). "Mechanism for down-regulation of CD28 by Nef". EMBO J. 20 (7): 1593–604. doi:10.1093/emboj/20.7.1593. PMID 11285224.CS1 maint: Multiple names: authors list (link)
• Laporte SA, Miller WE, Kim KM, Caron MG (2002). "beta-Arrestin/AP-2 interaction in G protein-coupled receptor internalization: identification of a beta-arrestin binging site in beta 2-adaptin". J. Biol. Chem. 277 (11): 9247–54. doi:10.1074/jbc.M108490200. PMID 11777907.CS1 maint: Multiple names: authors list (link)
• Collins BM, McCoy AJ, Kent HM; et al. (2002). "Molecular architecture and functional model of the endocytic AP2 complex". Cell. 109 (4): 523–35. PMID 12086608.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• He G, Gupta S, Yi M; et al. (2003). "ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2". J. Biol. Chem. 277 (46): 44044–9. doi:10.1074/jbc.M208539200. PMID 12221107.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cayrol C, Cougoule C, Wright M (2003). "The beta2-adaptin clathrin adaptor interacts with the mitotic checkpoint kinase BubR1". Biochem. Biophys. Res. Commun. 298 (5): 720–30. PMID 12419313.CS1 maint: Multiple names: authors list (link)
• Yao D, Ehrlich M, Henis YI, Leof EB (2003). "Transforming growth factor-beta receptors interact with AP2 by direct binding to beta2 subunit". Mol. Biol. Cell. 13 (11): 4001–12. doi:10.1091/mbc.02-07-0104. PMID 12429842.CS1 maint: Multiple names: authors list (link)
• Kalthoff C, Groos S, Kohl R; et al. (2003). "Clint: a novel clathrin-binding ENTH-domain protein at the Golgi". Mol. Biol. Cell. 13 (11): 4060–73. doi:10.1091/mbc.E02-03-0171. PMID 12429846.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)