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{{Underlinked|date=February 2015}}
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{{Infobox_gene}}
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'''AP-1 complex subunit sigma-2''' is a [[protein]] that in humans is encoded by the ''AP1S2'' [[gene]].<ref name="pmid9733768">{{cite journal | vauthors = Takatsu H, Sakurai M, Shin HW, Murakami K, Nakayama K | title = Identification and characterization of novel clathrin adaptor-related proteins | journal = The Journal of Biological Chemistry | volume = 273 | issue = 38 | pages = 24693–700 | date = Sep 1998 | pmid = 9733768 | pmc =  | doi = 10.1074/jbc.273.38.24693 }}</ref><ref name="pmid17186471">{{cite journal | vauthors = Tarpey PS, Stevens C, Teague J, Edkins S, O'Meara S, Avis T, Barthorpe S, Buck G, Butler A, Cole J, Dicks E, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, West S, Widaa S, Yates A, Catford R, Butler J, Mallya U, Moon J, Luo Y, Dorkins H, Thompson D, Easton DF, Wooster R, Bobrow M, Carpenter N, Simensen RJ, Schwartz CE, Stevenson RE, Turner G, Partington M, Gecz J, Stratton MR, Futreal PA, Raymond FL | title = Mutations in the gene encoding the Sigma 2 subunit of the adaptor protein 1 complex, AP1S2, cause X-linked mental retardation | journal = American Journal of Human Genetics | volume = 79 | issue = 6 | pages = 1119–24 | date = Dec 2006 | pmid = 17186471 | pmc = 1698718 | doi = 10.1086/510137 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AP1S2 adaptor-related protein complex 1, sigma 2 subunit| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8905| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Adaptor-related protein complex 1, sigma 2 subunit
| HGNCid = 560
| Symbol = AP1S2
| AltSymbols =; DC22; MGC:1902; SIGMA1B
| OMIM = 603532
| ECnumber = 
| Homologene = 84731
| MGIid = 
| Function = {{GNF_GO|id=GO:0008565 |text = protein transporter activity}}
| Component = {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0005802 |text = trans-Golgi network}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005905 |text = coated pit}} {{GNF_GO|id=GO:0030119 |text = AP-type membrane coat adaptor complex}} {{GNF_GO|id=GO:0030121 |text = AP-1 adaptor complex}} {{GNF_GO|id=GO:0030662 |text = coated vesicle membrane}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}} {{GNF_GO|id=GO:0006898 |text = receptor-mediated endocytosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8905
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_003907
    | Hs_RefseqmRNA = NM_003916
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
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'''Adaptor-related protein complex 1, sigma 2 subunit''', also known as '''AP1S2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: AP1S2 adaptor-related protein complex 1, sigma 2 subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8905| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Adaptor protein complex 1 is found at the [[cytoplasmic]] face of coated [[vesicle (biology and chemistry)|vesicles]] located at the [[Golgi complex]], where it mediates both the recruitment of [[clathrin]] to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small [[adaptin]] subunit. The protein encoded by this gene serves as the small subunit of this complex and is a member of the adaptin protein family. Transcript variants utilizing alternative [[polyadenylation]] signals exist for this gene.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as the small subunit of this complex and is a member of the adaptin protein family. Transcript variants utilizing alternative polyadenylation signals exist for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: AP1S2 adaptor-related protein complex 1, sigma 2 subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8905| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
{{Clear}}
 
==External links==
* {{UCSC gene info|AP1S2}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Kirchhausen T | title = Clathrin | journal = Annual Review of Biochemistry | volume = 69 | issue =  | pages = 699–727 | year = 2000 | pmid = 10966473 | doi = 10.1146/annurev.biochem.69.1.699 }}
| citations =
* {{cite journal | vauthors = Geyer M, Fackler OT, Peterlin BM | title = Structure--function relationships in HIV-1 Nef | journal = EMBO Reports | volume = 2 | issue = 7 | pages = 580–5 | date = Jul 2001 | pmid = 11463741 | pmc = 1083955 | doi = 10.1093/embo-reports/kve141 }}
*{{cite journal | author=Kirchhausen T |title=Clathrin. |journal=Annu. Rev. Biochem. |volume=69 |issue=  |pages= 699-727 |year= 2000 |pmid= 10966473 |doi= 10.1146/annurev.biochem.69.1.699 }}
* {{cite journal | vauthors = Bénichou S, Benmerah A | title = [The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway] | journal = Médecine Sciences | volume = 19 | issue = 1 | pages = 100–6 | date = Jan 2003 | pmid = 12836198 | doi = 10.1051/medsci/2003191100 }}
*{{cite journal | author=Geyer M, Fackler OT, Peterlin BM |title=Structure--function relationships in HIV-1 Nef. |journal=EMBO Rep. |volume=2 |issue= 7 |pages= 580-5 |year= 2001 |pmid= 11463741 |doi= 10.1093/embo-reports/kve141 }}
* {{cite journal | vauthors = Kirchhausen T, Davis AC, Frucht S, Greco BO, Payne GS, Tubb B | title = AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast | journal = The Journal of Biological Chemistry | volume = 266 | issue = 17 | pages = 11153–7 | date = Jun 1991 | pmid = 2040623 | doi =  }}
*{{cite journal | author=Bénichou S, Benmerah A |title=[The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway] |journal=Med Sci (Paris) |volume=19 |issue= 1 |pages= 100-6 |year= 2003 |pmid= 12836198 |doi= }}
* {{cite journal | vauthors = Craig HM, Pandori MW, Guatelli JC | title = Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 19 | pages = 11229–34 | date = Sep 1998 | pmid = 9736718 | pmc = 21624 | doi = 10.1073/pnas.95.19.11229 }}
*{{cite journal | author=Kirchhausen T, Davis AC, Frucht S, ''et al.'' |title=AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast. |journal=J. Biol. Chem. |volume=266 |issue= 17 |pages= 11153-7 |year= 1991 |pmid= 2040623 |doi=  }}
* {{cite journal | vauthors = Bresnahan PA, Yonemoto W, Ferrell S, Williams-Herman D, Geleziunas R, Greene WC | title = A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor | journal = Current Biology | volume = 8 | issue = 22 | pages = 1235–8 | date = Nov 1998 | pmid = 9811606 | doi = 10.1016/S0960-9822(07)00517-9 }}
*{{cite journal | author=Takatsu H, Sakurai M, Shin HW, ''et al.'' |title=Identification and characterization of novel clathrin adaptor-related proteins. |journal=J. Biol. Chem. |volume=273 |issue= 38 |pages= 24693-700 |year= 1998 |pmid= 9733768 |doi=  }}
* {{cite journal | vauthors = Greenberg M, DeTulleo L, Rapoport I, Skowronski J, Kirchhausen T | title = A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4 | journal = Current Biology | volume = 8 | issue = 22 | pages = 1239–42 | date = Nov 1998 | pmid = 9811611 | doi = 10.1016/S0960-9822(07)00518-0 }}
*{{cite journal  | author=Craig HM, Pandori MW, Guatelli JC |title=Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 19 |pages= 11229-34 |year= 1998 |pmid= 9736718 |doi= }}
* {{cite journal | vauthors = Berlioz-Torrent C, Shacklett BL, Erdtmann L, Delamarre L, Bouchaert I, Sonigo P, Dokhelar MC, Benarous R | title = Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins | journal = Journal of Virology | volume = 73 | issue = 2 | pages = 1350–61 | date = Feb 1999 | pmid = 9882340 | pmc = 103959 | doi =  }}
*{{cite journal | author=Bresnahan PA, Yonemoto W, Ferrell S, ''et al.'' |title=A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor. |journal=Curr. Biol. |volume=8 |issue= 22 |pages= 1235-8 |year= 1999 |pmid= 9811606 |doi= }}
* {{cite journal | vauthors = Wyss S, Berlioz-Torrent C, Boge M, Blot G, Höning S, Benarous R, Thali M | title = The highly conserved C-terminal dileucine motif in the cytosolic domain of the human immunodeficiency virus type 1 envelope glycoprotein is critical for its association with the AP-1 clathrin adaptor [correction of adapter] | journal = Journal of Virology | volume = 75 | issue = 6 | pages = 2982–92 | date = Mar 2001 | pmid = 11222723 | pmc = 115924 | doi = 10.1128/JVI.75.6.2982-2992.2001 }}
*{{cite journal | author=Greenberg M, DeTulleo L, Rapoport I, ''et al.'' |title=A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4. |journal=Curr. Biol. |volume=8 |issue= 22 |pages= 1239-42 |year= 1999 |pmid= 9811611 |doi= }}
* {{cite journal | vauthors = Doray B, Ghosh P, Griffith J, Geuze HJ, Kornfeld S | title = Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network | journal = Science | volume = 297 | issue = 5587 | pages = 1700–3 | date = Sep 2002 | pmid = 12215646 | doi = 10.1126/science.1075327 }}
*{{cite journal | author=Berlioz-Torrent C, Shacklett BL, Erdtmann L, ''et al.'' |title=Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins. |journal=J. Virol. |volume=73 |issue= 2 |pages= 1350-61 |year= 1999 |pmid= 9882340 |doi=  }}
* {{cite journal | vauthors = Janvier K, Craig H, Hitchin D, Madrid R, Sol-Foulon N, Renault L, Cherfils J, Cassel D, Benichou S, Guatelli J | title = HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes | journal = The Journal of Biological Chemistry | volume = 278 | issue = 10 | pages = 8725–32 | date = Mar 2003 | pmid = 12486136 | doi = 10.1074/jbc.M210115200 }}
*{{cite journal | author=Wyss S, Berlioz-Torrent C, Boge M, ''et al.'' |title=The highly conserved C-terminal dileucine motif in the cytosolic domain of the human immunodeficiency virus type 1 envelope glycoprotein is critical for its association with the AP-1 clathrin adaptor [correction of adapter]. |journal=J. Virol. |volume=75 |issue= 6 |pages= 2982-92 |year= 2001 |pmid= 11222723 |doi= 10.1128/JVI.75.6.2982-2992.2001 }}
* {{cite journal | vauthors = Coleman SH, Van Damme N, Day JR, Noviello CM, Hitchin D, Madrid R, Benichou S, Guatelli JC | title = Leucine-specific, functional interactions between human immunodeficiency virus type 1 Nef and adaptor protein complexes | journal = Journal of Virology | volume = 79 | issue = 4 | pages = 2066–78 | date = Feb 2005 | pmid = 15681409 | pmc = 546596 | doi = 10.1128/JVI.79.4.2066-2078.2005 }}
*{{cite journal | author=Doray B, Ghosh P, Griffith J, ''et al.'' |title=Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network. |journal=Science |volume=297 |issue= 5587 |pages= 1700-3 |year= 2002 |pmid= 12215646 |doi= 10.1126/science.1075327 }}
* {{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Coleman SH, Hitchin D, Noviello CM, Guatelli JC | title = HIV-1 Nef stabilizes AP-1 on membranes without inducing ARF1-independent de novo attachment | journal = Virology | volume = 345 | issue = 1 | pages = 148–55 | date = Feb 2006 | pmid = 16253302 | doi = 10.1016/j.virol.2005.09.045 }}
*{{cite journal  | author=Janvier K, Craig H, Hitchin D, ''et al.'' |title=HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes. |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 8725-32 |year= 2003 |pmid= 12486136 |doi= 10.1074/jbc.M210115200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Coleman SH, Van Damme N, Day JR, ''et al.'' |title=Leucine-specific, functional interactions between human immunodeficiency virus type 1 Nef and adaptor protein complexes. |journal=J. Virol. |volume=79 |issue= 4 |pages= 2066-78 |year= 2005 |pmid= 15681409 |doi= 10.1128/JVI.79.4.2066-2078.2005 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Coleman SH, Hitchin D, Noviello CM, Guatelli JC |title=HIV-1 Nef stabilizes AP-1 on membranes without inducing ARF1-independent de novo attachment. |journal=Virology |volume=345 |issue= 1 |pages= 148-55 |year= 2006 |pmid= 16253302 |doi= 10.1016/j.virol.2005.09.045 }}
}}
{{refend}}
{{refend}}
{{Vesicular transport proteins}}


{{protein-stub}}
{{protein-stub}}
{{WikiDoc Sources}}

Revision as of 17:01, 8 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

AP-1 complex subunit sigma-2 is a protein that in humans is encoded by the AP1S2 gene.[1][2][3]

Function

Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as the small subunit of this complex and is a member of the adaptin protein family. Transcript variants utilizing alternative polyadenylation signals exist for this gene.[3]

References

  1. ↑ Takatsu H, Sakurai M, Shin HW, Murakami K, Nakayama K (Sep 1998). "Identification and characterization of novel clathrin adaptor-related proteins". The Journal of Biological Chemistry. 273 (38): 24693–700. doi:10.1074/jbc.273.38.24693. PMID 9733768.
  2. ↑ Tarpey PS, Stevens C, Teague J, Edkins S, O'Meara S, Avis T, Barthorpe S, Buck G, Butler A, Cole J, Dicks E, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, West S, Widaa S, Yates A, Catford R, Butler J, Mallya U, Moon J, Luo Y, Dorkins H, Thompson D, Easton DF, Wooster R, Bobrow M, Carpenter N, Simensen RJ, Schwartz CE, Stevenson RE, Turner G, Partington M, Gecz J, Stratton MR, Futreal PA, Raymond FL (Dec 2006). "Mutations in the gene encoding the Sigma 2 subunit of the adaptor protein 1 complex, AP1S2, cause X-linked mental retardation". American Journal of Human Genetics. 79 (6): 1119–24. doi:10.1086/510137. PMC 1698718. PMID 17186471.
  3. ↑ 3.0 3.1 "Entrez Gene: AP1S2 adaptor-related protein complex 1, sigma 2 subunit".

External links

Further reading


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