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AP-1 complex subunit beta-1 is a protein that in humans is encoded by the AP1B1gene.[1][2][3]
Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein family. This gene is a candidate meningioma gene. Two transcript variants encoding different isoforms have been found for this gene, and variants utilizing alternative polyadenylation signals exist.[3]
↑Peyrard M, Fransson I, Xie YG, Han FY, Ruttledge MH, Swahn S, Collins JE, Dunham I, Collins VP, Dumanski JP (January 1995). "Characterization of a new member of the human beta-adaptin gene family from chromosome 22q12, a candidate meningioma gene". Hum Mol Genet. 3 (8): 1393–9. doi:10.1093/hmg/3.8.1393. PMID7987321.
↑Peyrard M, Pan HQ, Kedra D, Fransson I, Swahn S, Hartman K, Clifton SW, Roe BA, Dumanski JP (February 1997). "Structure of the promoter and genomic organization of the human beta'-adaptin gene (BAM22) from chromosome 22q12". Genomics. 36 (1): 112–7. doi:10.1006/geno.1996.0431. PMID8812422.
↑Nakagawa, T; Setou M; Seog D; Ogasawara K; Dohmae N; Takio K; Hirokawa N (November 2000). "A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex". Cell. UNITED STATES. 103 (4): 569–81. doi:10.1016/S0092-8674(00)00161-6. ISSN0092-8674. PMID11106728.
↑Takatsu, H; Sakurai M; Shin H W; Murakami K; Nakayama K (September 1998). "Identification and characterization of novel clathrin adaptor-related proteins". J. Biol. Chem. UNITED STATES. 273 (38): 24693–700. doi:10.1074/jbc.273.38.24693. ISSN0021-9258. PMID9733768.
↑Fölsch, H; Ohno H; Bonifacino J S; Mellman I (October 1999). "A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells". Cell. UNITED STATES. 99 (2): 189–98. doi:10.1016/S0092-8674(00)81650-5. ISSN0092-8674. PMID10535737.
Bénichou S, Benmerah A (2003). "[The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway]". Med Sci (Paris). 19 (1): 100–6. doi:10.1051/medsci/2003191100. PMID12836198.
Takatsu H, Sakurai M, Shin HW, et al. (1998). "Identification and characterization of novel clathrin adaptor-related proteins". J. Biol. Chem. 273 (38): 24693–700. doi:10.1074/jbc.273.38.24693. PMID9733768.
Bresnahan PA, Yonemoto W, Ferrell S, et al. (1999). "A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor". Curr. Biol. 8 (22): 1235–8. doi:10.1016/S0960-9822(07)00517-9. PMID9811606.
Greenberg M, DeTulleo L, Rapoport I, et al. (1999). "A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4". Curr. Biol. 8 (22): 1239–42. doi:10.1016/S0960-9822(07)00518-0. PMID9811611.
Fölsch H, Ohno H, Bonifacino JS, Mellman I (1999). "A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells". Cell. 99 (2): 189–98. doi:10.1016/S0092-8674(00)81650-5. PMID10535737.
Kim ST, Lim DS, Canman CE, Kastan MB (2000). "Substrate specificities and identification of putative substrates of ATM kinase family members". J. Biol. Chem. 274 (53): 37538–43. doi:10.1074/jbc.274.53.37538. PMID10608806.
Lai MM, Luo HR, Burnett PE, et al. (2000). "The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis". J. Biol. Chem. 275 (44): 34017–20. doi:10.1074/jbc.C000429200. PMID10931822.
Nakagawa T, Setou M, Seog D, et al. (2001). "A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex". Cell. 103 (4): 569–81. doi:10.1016/S0092-8674(00)00161-6. PMID11106728.
Takatsu H, Futatsumori M, Yoshino K, et al. (2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three-hybrid system". Biochem. Biophys. Res. Commun. 284 (4): 1083–9. doi:10.1006/bbrc.2001.5081. PMID11409905.
